Arterial Infusion Chemotherapy for Hepatic Metastases
In the treatment of primary and secondary liver cancer, the respective roles of surgery and chemotherapy are far from being established. Surgical treatment by itself is preferred for primary hepatic tumors, bulky solitary metastases, and smaller hepatic metastases limited to one lobe (Pettavel and Meyer 1979). In addition, the excision of one or even several metastases is generally preferable before instituting chemotherapy. The logical basis for arterial chemotherapy as treatment for liver metastases has been described elsewhere (Pettavel and Morgenthaler 1970). There is a considerable choice of methods, associated with different adjuvant means: mono- or polychemotherapy, continuous or intermittent injections, simultaneous or sequential chemotherapy. All these can be used alone or in association with some form of hepatic ischemia: complete liver dearterialization, ligation of one or all main liver arteries, temporary occlusion of the hepatic artery (Bengmark and Fredlund 1978), and eventually some form of arterial embolization.
KeywordsHepatic Artery Hepatic Metastasis Infusion Chemotherapy Hepatic Arterial Infusion Hepatic Arterial Infusion Chemotherapy
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