Advertisement

Arterial Infusion Chemotherapy for Hepatic Metastases

  • J. Pettavel
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 86)

Abstract

In the treatment of primary and secondary liver cancer, the respective roles of surgery and chemotherapy are far from being established. Surgical treatment by itself is preferred for primary hepatic tumors, bulky solitary metastases, and smaller hepatic metastases limited to one lobe (Pettavel and Meyer 1979). In addition, the excision of one or even several metastases is generally preferable before instituting chemotherapy. The logical basis for arterial chemotherapy as treatment for liver metastases has been described elsewhere (Pettavel and Morgenthaler 1970). There is a considerable choice of methods, associated with different adjuvant means: mono- or polychemotherapy, continuous or intermittent injections, simultaneous or sequential chemotherapy. All these can be used alone or in association with some form of hepatic ischemia: complete liver dearterialization, ligation of one or all main liver arteries, temporary occlusion of the hepatic artery (Bengmark and Fredlund 1978), and eventually some form of arterial embolization.

Keywords

Hepatic Artery Hepatic Metastasis Infusion Chemotherapy Hepatic Arterial Infusion Hepatic Arterial Infusion Chemotherapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bengmark S, Fredlund PE (1978) Temporary dearterialization combined with intra-arterial infusion of oncolytic drugs in the treatment of liver tumors. In: Ariel IM (ed) Progress in clinical cancer VII. Grune and Stratton, New York, pp 207–216Google Scholar
  2. Cady B, Oberfield RA (1974) Regional infusion chemotherapy of hepatic metastases from carcinoma of the colon. Am J Surg 127: 220–227PubMedCrossRefGoogle Scholar
  3. Clouse ME, Ahmed R, Ryan RB, Oberfield RA, McCaffrey JA (1977) Complications of long-term transbrachial hepatic arterial infusion chemotherapy. Am J Roentgenol 129: 799–803Google Scholar
  4. Jaffe BM, Donegan WL, Watson F, Spratt JS Jr (1968) Factors influencing survival in patients with untreated hepatic metastases. Surg Gynecol Obstet 127: 1–11PubMedGoogle Scholar
  5. Jochimsen PR, Zike WL, Shirazi SS, Pearlman NW (1978) latrogenic liver abscesses. Arch Surg 113: 141–144PubMedCrossRefGoogle Scholar
  6. Lavin P, Mittelman A, Douglass H Jr, Engstrom P, Klaasen D (1980) Survival and response to chemotherapy for advanced colorectal adenocarcinoma: an Eastern Cooperative Oncology Group report. Cancer 46: 1536–1543PubMedCrossRefGoogle Scholar
  7. Mach JP, Vienny H, Jaeger P, Haldemann B, Egeli R, Pettavel J (1978) Long-term follow-up of colo-rectal carcinoma patients by repeated CEA Radioimmunoassay. Cancer 42: 1439–1477PubMedCrossRefGoogle Scholar
  8. Nielsen J, Balslev I, Jensen HE (1971) Carcinoma of the colon with liver metastases. Acta Chir Scand 137: 463–465PubMedGoogle Scholar
  9. Patt YZ, Chuang VP, Wallace S, Hersh EM, Freireich EJ, Mavligit GM (1981) The palliative role of hepatic arterial infusion and arterial occlusion in colorectal carcinoma metastatic to the liver. Lancet 349–351Google Scholar
  10. Pestana C, Reitemeier JR, Moertel CG, Judd ES, Dockerty MB (1964) The natural history of carcinoma of the colon and rectum. Am J Surg 108: 826–829PubMedCrossRefGoogle Scholar
  11. Pettavel J, Meyer A (1979) Indication sélective à l’exérèse chirurgicale des métastases hépatiques. Schweiz Med Wochenschr 109: 794–796PubMedGoogle Scholar
  12. Pettavel J, Morgenthaler F (1970) The treatment of hepatic metastases by long-term chemotherapeutic infusions. In: Saegesser F, Pettavel J (eds) Surgical oncology. Williams and Wilkins, Baltimore, pp 865–881Google Scholar
  13. Pettavel J, Morgenthaler F (1976) Dix ans d’expérience de chimiothérapie artérielle des tumeurs primaires et secondaires du foie. Ann Gastroenterol Hepatol 12: 349–363Google Scholar
  14. Pettavel J, Morgenthaler F (1978) Protracted arterial chemotherapy of liver tumors: An experience of 107 cases over a 12-year period. In: Ariel IM (ed) Progress in clinical cancer VII. Grune and Stratton, New York, pp 217–223Google Scholar
  15. Watkins EJ, Khazei AM, Nahra KS (1970) Surgical basis for arterial infusion chemotherapy of disseminated carcinoma to the liver. Surg Gynec Obstet 130: 580–605Google Scholar
  16. Wood CB, Gillis CR, Blumgart LH (1976) A retrospective study of the natural history of patients with liver metastases from colorectal cancer. Clin Oncol 2: 285–288PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1983

Authors and Affiliations

  • J. Pettavel
    • 1
  1. 1.Department of SurgeryUniversity of Lausanne Medical School CenterLausanneSwitzerland

Personalised recommendations