Arterial Infusion Chemotherapy for Hepatic Metastases
In the treatment of primary and secondary liver cancer, the respective roles of surgery and chemotherapy are far from being established. Surgical treatment by itself is preferred for primary hepatic tumors, bulky solitary metastases, and smaller hepatic metastases limited to one lobe (Pettavel and Meyer 1979). In addition, the excision of one or even several metastases is generally preferable before instituting chemotherapy. The logical basis for arterial chemotherapy as treatment for liver metastases has been described elsewhere (Pettavel and Morgenthaler 1970). There is a considerable choice of methods, associated with different adjuvant means: mono- or polychemotherapy, continuous or intermittent injections, simultaneous or sequential chemotherapy. All these can be used alone or in association with some form of hepatic ischemia: complete liver dearterialization, ligation of one or all main liver arteries, temporary occlusion of the hepatic artery (Bengmark and Fredlund 1978), and eventually some form of arterial embolization.
KeywordsToxicity Catheter Ischemia Adenocarcinoma Oncol
Unable to display preview. Download preview PDF.
- Bengmark S, Fredlund PE (1978) Temporary dearterialization combined with intra-arterial infusion of oncolytic drugs in the treatment of liver tumors. In: Ariel IM (ed) Progress in clinical cancer VII. Grune and Stratton, New York, pp 207–216Google Scholar
- Clouse ME, Ahmed R, Ryan RB, Oberfield RA, McCaffrey JA (1977) Complications of long-term transbrachial hepatic arterial infusion chemotherapy. Am J Roentgenol 129: 799–803Google Scholar
- Patt YZ, Chuang VP, Wallace S, Hersh EM, Freireich EJ, Mavligit GM (1981) The palliative role of hepatic arterial infusion and arterial occlusion in colorectal carcinoma metastatic to the liver. Lancet 349–351Google Scholar
- Pettavel J, Morgenthaler F (1970) The treatment of hepatic metastases by long-term chemotherapeutic infusions. In: Saegesser F, Pettavel J (eds) Surgical oncology. Williams and Wilkins, Baltimore, pp 865–881Google Scholar
- Pettavel J, Morgenthaler F (1976) Dix ans d’expérience de chimiothérapie artérielle des tumeurs primaires et secondaires du foie. Ann Gastroenterol Hepatol 12: 349–363Google Scholar
- Pettavel J, Morgenthaler F (1978) Protracted arterial chemotherapy of liver tumors: An experience of 107 cases over a 12-year period. In: Ariel IM (ed) Progress in clinical cancer VII. Grune and Stratton, New York, pp 217–223Google Scholar
- Watkins EJ, Khazei AM, Nahra KS (1970) Surgical basis for arterial infusion chemotherapy of disseminated carcinoma to the liver. Surg Gynec Obstet 130: 580–605Google Scholar