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Automation of Pap Smear Analysis: A Review and Status Report

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Pictorial Data Analysis

Part of the book series: NATO ASI Series ((NATO ASI F,volume 4))

Abstract

In most western countries approximately one fourth of all deaths are attributable to some form of cancer. It is generally believed that when a developing cancer is detected at a stage at which its extent is still limited there is a good chance that it can be eradicated, allowing the patient to continue to lead a normal life. Cancer of the uterine cervix is one type of cancer with which “early detection” and treatment of cytologically detectable precancerous abnormalities seem to lead to a significant decline in the incidence of and deaths from later stages of cancer.

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References

  1. Al I, Ploem JS: Detection of suspicious cells and rejection of artifacts in cervical cytology using the Leyden television analysis system. J Histochem Cytochem 27:629, 1979

    Article  Google Scholar 

  2. Bostrom RC, Sawyer HS, Tolles WE: Instrumentation for automatically prescreening cytological smears. Proc IRE 47:1895, 1959

    Article  Google Scholar 

  3. Bostrom RC, Holcomb WG: CYDAC-a digital scanning cytophotometer. IEEE Int Conv Rec part 9:110, 1979

    Google Scholar 

  4. Castleman KR, White BS: Optimizing cervical cell classifiers. Anal Quant Cytol 2:117, 1980

    Google Scholar 

  5. Castleman KR, White BS: Optimizing cervical specimen classifiers. IEEE Trans Patt Anal Mach Intel 2:451, 1980

    Google Scholar 

  6. Christopherson WM: The conrol of cervix cancer. Acta Cytol 10:6, 1966

    Google Scholar 

  7. Deeley EM: An integrating microdensitometer for biological cells. J Sci Instrum 32:263, 1955

    Article  Google Scholar 

  8. van Duijn P: A histochemical specific thionine-SO2 reagent and its use in a bi-color method for deoxyribonucleic acid and periodic acid Schiff positive substances. J Histochem Cytochem 4:55, 1956

    Article  Google Scholar 

  9. Erhardt R, Reinhardt ER, Schlipf W, Bloss WH: Fazytan, a system for fast automated cell segmentation, cell image analysis and feature extraction based on TV-image pickup and parallel processing. Anal Quant Cytol 2:25, 1980

    Google Scholar 

  10. Fisher C, Bond CP: The Quantimet 72OD for densitometry in the life sciences. Microscope 20:203, 1972

    Google Scholar 

  11. Helwig FC: Changing ratio of cervical to corpus carcinoma. Am J Obstet Gynecol 81:277, 1961

    Google Scholar 

  12. Husain OAN, Allen RWB, Hawkins EF, Taylor JE: The Quantimet cytoscreen and the interactive approach to cancer screening. J Histochem Cytochem 22:678, 1974

    Article  Google Scholar 

  13. Mendelsohn ML, Mayall BH, PrewittJMS, Bostrom RC, Holcromb WG: Digital transformation and compute analysis of microscopic images. Advances in Optical and Electron Microscopy, vol 2. Edited by R Barer and VE Cosslett. Academic Press, New York, 1968. p 77

    Google Scholar 

  14. Meyer EW: Vickers continuous film. Cytology Automation. Edited by DMD Evans. E and S Livingstone Ltd, London, 1970. p 147

    Google Scholar 

  15. Oud PS, Zahniser DJ, van Boekel MCG, Vooys GP: Feulgen-Thionine/Congo Red: A Cervical smear staining procedure for the BioPEPR prescreening system. Anal Quant Cytol 4:289, 1981

    Google Scholar 

  16. Oud PS, Zahniser DJ, Harbers-Hendriks R, van Boekel MCG, Vooys GP, Raaijmakers MCT, Van de Walle RT: The development of a cervical smear preparation procedure for the BioPEPR image analysis system. Anal Quant Cytol 3:73, 1981

    Google Scholar 

  17. Papanicolaou GN, Traut HG: Diagnosis of Uterine Cancer by the Vaginal Smear. The Commonwealth Fund, New York, 1943

    Google Scholar 

  18. van der Ploeg M, van Duijn P, Ploem JS: High-resolution scanning-densitometry of photographic negatives of human metaphase chromosomes: Instrumentation. Histochemistry 42:9, 1974

    Article  Google Scholar 

  19. Ploem JS, Verwoerd N, Bonnet J, Koper G: An automated microscope for quantitative cytology combining television image analysis and stage screening microphotometry. J Histochem Cytochem 27: 136, 1979

    Article  Google Scholar 

  20. Poulsen RS. Oliver LH, Cahn RL, Louis C, Toussaint G: High resolution analysis of cervical cells -a progress report. J Histochem Cytochem 25:689, 1977

    Article  Google Scholar 

  21. Pycock D, Taylor CJ: Use of the MAGISCAN image analyser in automated uterine cancer cytology. Anal Quant Cytol 2:195, 1980

    Google Scholar 

  22. Shack R, Baker R, Buchroeder R, Hillman D, Shoemaker R, Bartels PH: Ultrafast laser scanner microscope. J Histochem Cytochem 27:153, 1979

    Article  Google Scholar 

  23. Shippey G, Bayley R, Farrow S, Lutz R, Rutovitz D: A fast interval processor (FIP; for cervical prescreening. Anal Quant Cytol 3:9, 1981

    Google Scholar 

  24. Spencer CC, Bostrom RC: Performance of the Cytoanalyzer in recent clinical trials. J Nat Cancer Instit 29: 267, 1962

    Google Scholar 

  25. Tanaka N, Ikeda H, Ueno T, Watanabe S, Imasata Y, Kashida R: Fundamental Study on automatic cyto-screening for uterine cancer. III. New system of automated apparatus (CYBEST) utilizing the pattern recognition method. Acta Cytol 21:85, 1977

    Google Scholar 

  26. Tanaka N, Ikeda H, Ueno T, Mukawa A, Kamitsuma K: Field test and experimental use of CYBEST model 2 for practical gynecologic mass screening. Anal Quant Cytol 1:122, 1979

    Google Scholar 

  27. Taylor J, Puis J, Sychra JJ, Bartels PH, Bibbo M, Wied GL: A system for scanning biological cells in three colors. Acta Cytol 22:29, 1978

    Google Scholar 

  28. Tucker JH: Automatic detection and classification of cells in cervical smears. Acta Cytol 15:138, 1971

    Google Scholar 

  29. Tucker JH, Gresham GA: preparation of cervical scrape material for automatic screening. J Obstet Gynaecol Br Comonw 78:947, 1971

    Article  Google Scholar 

  30. Tucker JH: An image analysis system for cervical cytology automation using nuclear DNA content. J Histochem Cytochem 27: 613, 1979

    Article  Google Scholar 

  31. Wheeless LLJr, Patten SF: Slit-scan cytoflourometry: basis for an automated cytopathology prescreening system. Acta Cytol 17:391, 1973

    Google Scholar 

  32. Wheeless LLJr, Onderdonk MA: Preparation of clinical gynecologic specimens for automated analysis: an overview. J Histochem Cytochem 22:522, 1974

    Article  Google Scholar 

  33. Wied GL, Bartels PH, Bahr GF, Oldfield DG: Taxonomic intracellular analytic system (TICAS) for cell identification. Acta Cytol 12:180, 1968

    Google Scholar 

  34. Wied GL, Bartels PH, Bibbo M, Keebler CM: Clinical sampling methods and evaluation of sampling techniques, The Automation of Cancer Cytology and Cell Image Analysis. Edited by GL Wied, GF Bahr, PH Bartels. Tutorials of Cytology, Chicago, 1976. p 15

    Google Scholar 

  35. Wied GL. Bahr GF, Bibbo M, Puls JH, Taylor J, Bartels PH: The TICAS-RTCIP real time cell identification processor. Acta Cytol 19:286, 1975

    Google Scholar 

  36. Zahniser DJ: The development of a fully automatic system for the prescreening of cervical smears: BioPEPR. PhD thesis. Nijmegen, The Netherlands, 1979

    Google Scholar 

  37. Zahniser DJ, Oud PS, Raaijmakers MCT, Vooijs GP, van de Walle RT: BioPEPR: a system for the automatic prescreening of cervical smears. J Histochem Cytochem 27:635, 1979

    Article  Google Scholar 

  38. Zahniser DJ, Oud PS, Raaijmakers MCT, Vooijs GP, van de Walle RT: Field test results using the BioPEPR cervical smear prescreening system. Cytometry 1:200, 1980

    Article  Google Scholar 

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© 1983 Springer-Verlag Berlin Heidelberg

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Zahniser, D.J. (1983). Automation of Pap Smear Analysis: A Review and Status Report. In: Haralick, R.M. (eds) Pictorial Data Analysis. NATO ASI Series, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82017-5_13

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  • DOI: https://doi.org/10.1007/978-3-642-82017-5_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-82019-9

  • Online ISBN: 978-3-642-82017-5

  • eBook Packages: Springer Book Archive

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