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Effects of Dietary Cholesterol and Saturated Fat on the Appearance of HDLc in Peripheral and Cardic Lymph

  • P. Julien
  • A. Angel
Conference paper

Abstract

Several studies on the kinetics of plasma LDL clearance and turnover indicate that up to 30 to 40% of LDL and HDL distribute in extravascular pools (1,2). Apoproteins known to be associated with VLDL, LDL and HDL have been detected in human peripheral (pedal) lymph by Reichl et al (3). In previous work, we have demonstrated that cholesterolrich lipoproteins, LDL and HDL, are present in cardiac lymph of pigs and dogs at concentrations 36 to 59% that of plasma and that cardiac lymph contained VLDL-like particles (4). Dietary effects on lipoproteins in peripheral lymph were observed by Courtice et al (5) who cannulated lymphatic vessels in hind limbs of hyperlipoproteinemic rabbits. Presumably lipoproteins in the interstitial space can undergo metabolic transformations because of the presence of lipid metabolizing enzymes (6) and because of proximity to lipoprotein binding sites on various parenchymal and mesenchymal cells.

Keywords

Plasma Lipoprotein Peripheral Lymph Cholesterol Feeding Lymph Lipid Cholesterol Carrier 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • P. Julien
  • A. Angel

There are no affiliations available

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