Measurement of Atherosclerosis by Arteriography and Microdensitometry: Model and Clinical Investigations
In recent years it has become clear that the use of clinical end points such as myocardial infarcts as a measure of the effect of serum lipid lowering carry considerable drawbacks, although it is the final goal of the preventive treatment. To get a more direct estimate of the effect of the treatment on the target — the atheroma — methods have been developed to quantitate small atheroma present in vivo in human beings (1). The present ongoing study uses as end point sequential computer estimated femoral atherosclerosis derived from arteriography. Asymptomatic men with massive hyperlipidaemia have been treated vigorously with potent serum lipid lowering drugs. Here we describe the angiographic and densitometric procedure and report the effect on atheroma development in the first eight consecutive cases treated with diet and drugs.
KeywordsPlacebo Cholesterol Fractionation Prostaglandin Triglyceride
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- 2.Fredrickson DS, Levy RI, Jones E, Bonneil M, Ernst N (1971) Dietary management of hyperlipoproteinemia. NHLBI Bethesda, Maryland.Google Scholar
- 5.Beaumont JL, Carlson LA, Cooper GR, Fejfar Z, Fredrickson DS, Strasser T (1970) Classification of hyperlipidaemias and hyperlipoproteinaemias. Bull Wld Hlth Org 43: 891–915Google Scholar
- 6.Carlson LA, Ericsson M, Erikson U (1973) Prostaglandin E, (PGE1) in peripheral arteriographies. Acta Radiol 14: 583–587Google Scholar
- 7.Ruhn G, Erikson U, Helmius G, Hemmingsson A (1982) Computerized quantitation of atherosclerosis by arteriography and microdensitometry — A model study. Acta Radiol, in pressGoogle Scholar