Abstract
WHHL rabbit is short for the Watanabe Heritable Hyperlipidemic rabbit. This strain has been inherited by inbreeding a mutant of hyperlipidemic rabbit found in Japanese white rabbits (Oryctolagus cuniculus Var. domesticus).
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References
Watanabe Y (1980) Serial inbreeding of rabbit with hereditary hyper- pipidemia (WHHL) — Incidence and development of atherosclerosis and xanthoma. Atherosclerosis 36 (2): 261–268
Tanzawa K, Shimada Y., Kuroda M., Tsujita Y., Arai M, Watanabe Y WHHL rabbit, a low density lipiprotein receptor-deficient animal model for familial hypercholesterolemia. FEBS Let 118 (1): 81–84
Shimada Y., Tanzawa K., Kuroda M., Tsujita Y., Arai M, Watanabe Y Biochemical characterization of skin fibroblast derived from WHHL rabbit, a notable animal model for familial hypercholesterolemia. Eur J Biochem 118: 557–564
Kita T, Brown MS, Watanabe Y, Goldstein JL (1981) Deficiency of LDL receptor in liver and adrenal gland of the WHHL rabbit, An animal model of familial hypercholesterolemia. Proc Natl Acad Sci USA 7 8 (4) 2268–2272
Attie AC, Pittman RC, Watanabe Y, Steinberg D (1981) Low density lipoprotein receptor deficiency in cultured hepatocytes of the WHHL rabbit. J Biol Chem 256 (19): 9789–9792
Kawai K, Maruno H, Watanabe Y, Hirohata K (1980) Fat necrosis of osteocytes as a causative factor in idiopathic osteonecrosis in hyperpipidemic ra-bits. Clin Orthopaedics 153: 273–282
Ito T, Watanabe Y, Shiomi M (1982) Spontaneous coronary atherosclerosis in immature stage of WHHL rabbit. J Jap coll Angiol 22 (4): 229–232
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© 1983 Springer-Verlag Berlin Heidelberg
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Watanabe, Y., Tsujita, Y., Izumi, A. (1983). WHHL Rabbit. A Heritable Animal Model of Familial Hypercholesterolemia. In: Schettler, F.G., Gotto, A.M., Middelhoff, G., Habenicht, A.J.R., Jurutka, K.R. (eds) Atherosclerosis VI. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81817-2_24
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DOI: https://doi.org/10.1007/978-3-642-81817-2_24
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-81819-6
Online ISBN: 978-3-642-81817-2
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