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A Controlled Trial of Substantial Reduction of Plasma Lipids in Symptomatic Atherosclerosis: An Angiographic Study

  • R. G. M. Duffield
  • B. Lewis
  • N. E. Miller
  • C. W. Jamieson
Conference paper

Abstract

Hypercholesterolaemia, low HDL Cholesterol levels and hypertriglyceridaemia are predictive of increased risk of atherosclerotic diseases. To establish that these associations represent cause and effect, however, it is necessary to show that control of these risk factors favourably affects the natural history of atherosclerosis and its consequences. Three forms of intervention study have been carried out in man, in which plasma lipoprotein levels have been modified by diet, drugs or other therapeutic measures1. Most trials of primary prevention of coronary heart disease (CHD) have suggested that its incidence is reduced1; in the most rigorously-designed trial a lipid lowering diet together with anti-smoking counselling was employed 2. Of the CHO secondary prevention trials same have achieved a reduction in events while others have had negative outcomes.

Keywords

Usual Care Group Intermittent Claudication Secondary Prevention Trial Lipid Lowering Diet Plasma Lipoprotein Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Lewis B (.1981) Ischemic heart disease: the scientific bases of prevention. In Progress in Cardiology 10: 21–44. Eds PN Yu, JF Goodwin. Philadelphia: Lea and FebigerGoogle Scholar
  2. 2.
    Hjerrman I, Byre KV, Holme I, Leren P (1981) Effect of diet and smoking intervention on the incidence of coronary heart disease. Lancet ii: 1303–10CrossRefGoogle Scholar
  3. 3.
    Zelis R, Mason DI, Braunwald E, Levy RI (1970) Effects of hyper- 1ipoproteinemias and their treatment on the peripheral circulation. J Clin Invest 49: 1007–15PubMedCrossRefGoogle Scholar
  4. 4.
    Malinow MR (1981) Regression of atherosclerosis in humans: fact or myth? Circulation 64: 1–3PubMedCrossRefGoogle Scholar
  5. 5.
    Barndt R Jr, Blankenhorn DH, Crawford DW, Brooks SM (1977) Regression and progression of early femoral atherosclerosis in treated hyper- 1ipoproteinemic patients. Ann Intern Med 86: 139–46PubMedGoogle Scholar
  6. 6.
    Lewis B (1980) The LDL theory and the HDL hypothesis. In Diet and Drugs in Atherosclerosis, p 1–8. Eds G Noseda, B Lewis, R Paoletti. New York: RavenGoogle Scholar
  7. 7.
    Armstrong ML, Megan MB (1972) Lipid depletion in atheromatous coronary arteries in Rhesus monkeys after regression diets. Circ Res 30: 675–80PubMedGoogle Scholar
  8. 8.
    Wissler RW, Vesselinovitch D (1976) Studies of regression of advanced atherosclerosis in experimental animals and man. Ann N Y Acad Sci 275: 363–78PubMedCrossRefGoogle Scholar
  9. 9.
    Wagner WD, St Clair RW, Clarkson TB (1980) A study of atherosclerosis regression in Macaca Mulatta II. Am J Pathol 100: 633PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • R. G. M. Duffield
  • B. Lewis
  • N. E. Miller
  • C. W. Jamieson

There are no affiliations available

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