A Controlled Trial of Substantial Reduction of Plasma Lipids in Symptomatic Atherosclerosis: An Angiographic Study

  • R. G. M. Duffield
  • B. Lewis
  • N. E. Miller
  • C. W. Jamieson
Conference paper


Hypercholesterolaemia, low HDL Cholesterol levels and hypertriglyceridaemia are predictive of increased risk of atherosclerotic diseases. To establish that these associations represent cause and effect, however, it is necessary to show that control of these risk factors favourably affects the natural history of atherosclerosis and its consequences. Three forms of intervention study have been carried out in man, in which plasma lipoprotein levels have been modified by diet, drugs or other therapeutic measures1. Most trials of primary prevention of coronary heart disease (CHD) have suggested that its incidence is reduced1; in the most rigorously-designed trial a lipid lowering diet together with anti-smoking counselling was employed 2. Of the CHO secondary prevention trials same have achieved a reduction in events while others have had negative outcomes.


Usual Care Group Intermittent Claudication Secondary Prevention Trial Lipid Lowering Diet Plasma Lipoprotein Level 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • R. G. M. Duffield
  • B. Lewis
  • N. E. Miller
  • C. W. Jamieson

There are no affiliations available

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