Advertisement

Immunohistology of Aortic Fatty Streaks in Children and Adults

  • K. W. Walton
Conference paper

Abstract

The W.H.O. Study Group on the Classification of Atherosclerotic Lesions in 1958 defined the term “fatty streak or spot” as one applied “to superficial yellow or yellowish-grey intimal lesions which are stained selectively by fat stains” (1). The Group did not attempt to reach an agreement on the stages of progression of various changes from the earliest recognisable lesions to the onset of clinical disease. Perhaps because of this, the origin, fate and significance in relation to the development of atherosclerosis of these lesions is still a matter of controversy.

Keywords

Atherosclerotic Lesion Fatty Streak Proximal Aorta Arterial Intima Muscular Coat 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    World Health Organisation (1958) Classification of atherosclerotic lesions. Wld Hlth Org techn Rep Ser No: 143Google Scholar
  2. 2.
    Geer JC, McGill HC, Strong JP (1961) The fine structure of human atherosclerotic lesions. Amer J Pathol 38: 263–288Google Scholar
  3. 3.
    Haust MD (1971) The morphogenesis and fate of potential and early atherosclerotic lesions in man. Hum Pathol 2: 1–30PubMedCrossRefGoogle Scholar
  4. 4.
    Schaffner T, Taylor K, Bartucci EJ, Fischer-Dzoga K, Beeson JH, Glagov S, Wissler RW (1980) Arterial foam cells with distinctive immunomorphologic and histochemical features of macrophages. Amer J Pathol 100: 57–74Google Scholar
  5. 5.
    Walton, KW (1972) The role of serum lipoproteins in very early and in late atherosclerosis. In: Connective Tissue and Ageing (Vogel HC, ed) Excerpta Medica, Amsterdam, pp34–37Google Scholar
  6. 6.
    Walton KW, Williamson N (1968) Histological and immunofluorescent studies on the evolution of the human atheromatous plaque. J Atheroscler Res 8: 599–624PubMedCrossRefGoogle Scholar
  7. 7.
    Walton KW (1975). Pathogenetic mechanisms in atherosclerosis. Amer J Cardiol 35: 542–558PubMedCrossRefGoogle Scholar
  8. 8.
    Walton KW (1978) Atherosclerosis and aging. In: Brocklehurst JC(ed) Textbook of geriatric medicine and gerontology 2nd edn Chap 5, Churchill Livingstone EdinburghGoogle Scholar
  9. 9.
    Bradby GVH, Walton KW, Watts R (1979) The binding of total low- density lipoproteins in human arterial intima affected and unaffected by atherosclerosis. Atherosclerosis 32: 403–422PubMedCrossRefGoogle Scholar
  10. 10.
    Duncan LE, Cornfield J, Buck K (1962) The effect of blood pressure on the passage of labelled plasma albumin into canine aortic wall. J Clin Invest 41: 1537–1545PubMedCrossRefGoogle Scholar
  11. 11.
    Walton KW. The role of lipoproteins in human atherosclerosis In: Peeters H (ed) The Lipoprotein Molecule, Plenum Press, New YorkGoogle Scholar
  12. 12.
    Mitchell JRA, Schwartz CJ (1965) Arterial Disease, Blackwell, OxfordGoogle Scholar
  13. 13.
    Pearson TA, Dillman JM, Solez K, Hepinstall RH (1980) Evidence for two populations of fatty streaks with different roles in the atherogenic process. Lancet 2: 496–498PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • K. W. Walton

There are no affiliations available

Personalised recommendations