Dynamics of Molecular Recognition in Enzyme-Catalyzed Reactions
The initial chemical reaction step of a large number of complicated processes in living organisms is the association of a low molecular weight ligand to a specific macromolecular binding site. Among the examples for this observation we find substrate enzyme and hormone receptor reactions as well as metal ion activation of proteins and other functionally important biomacromolecular processes. Frequently, the ligand-binding phase is described in anthropomorphic terms such as recognition, discrimination and selection. The meaningful use of these words is, however, limited if more than just binding is to be expressed.
KeywordsEntropy Enthalpy Carboxylate Trypsin Choline
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- 3.Guggenheim EA (1967) Thermodynamics, 5th ed., North-Holland Pubi Co AmsterdamGoogle Scholar
- 4.Smoluchowski Mv (1916) Physik Z 17: 557–585; Z Phys Chem 92: 129 (1927)Google Scholar
- 7.Eigen M (1974) in: Quantum statistical mechanics in the natural sciences, eds. Mintz S L, Widmayer SM, Plenum Press, New York pp. 37–61Google Scholar
- 10.Eigen M, Kruse W, Maass G, DeMayer L (1964) Progress in reaction kinetics 2: 287–318Google Scholar
- 12.Neumann E, Rosenberry TL, Chang HW (1978) in: Neuronal information transfer, eds. Karlin A, Academic Press, New York pp. 183–210Google Scholar
- 20.Neumann E, Nolte H-J (1980) Studia Biophys 81: 109–110Google Scholar