Dynamics of Molecular Recognition in Enzyme-Catalyzed Reactions

  • E. Neumann
Conference paper
Part of the Colloquium der Gesellschaft für Biologische Chemie 23.–25. April 1981 in Mosbach/Baden book series (MOSBACH, volume 32)

Abstract

The initial chemical reaction step of a large number of complicated processes in living organisms is the association of a low molecular weight ligand to a specific macromolecular binding site. Among the examples for this observation we find substrate enzyme and hormone receptor reactions as well as metal ion activation of proteins and other functionally important biomacromolecular processes. Frequently, the ligand-binding phase is described in anthropomorphic terms such as recognition, discrimination and selection. The meaningful use of these words is, however, limited if more than just binding is to be expressed.

Keywords

Entropy Enthalpy Carboxylate Trypsin Choline 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • E. Neumann
    • 1
  1. 1.Max-Planck-Institut für BiochemieMartinsried/MünchenGermany

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