Summary
Our chemoimmunotherapy study shows significantly longer remission and survival in acute myelocytic leukemia (AML) patients who have been immunized with neuraminidase-treated allogeneic myeloblasts as compared to patients who received chemotherapy alone or neuraminidase-treated myeloblasts plus MER. MER impairs the immunotherapeutic effectiveness of neuraminidase-treated allogeneic myeloblasts in AML patients. The in vivo and in vitro immunologic status in each arm of the protocol correlate well with the duration of remission and survival of the patient.
This work was supported in part by grant and contracts CA-1-5936-02, CA-5834, NCI Cancer Virus Program 1-CB-43879 and NCI Immunotherapy Program 1-CO-432225, and the T.J. Martell Memorial Fund for Leukemia Research. We express our appreciation to the Behring Institute,Behringwerk AG,Marburg, Federal Republic of Germany, for supplying the highly purified neuraminidase for this study. We also thank Patricia Mason, Svetlana Perova, and Khanitha Tangnavarad for the excellent assistance in performing the immunotherapeutic manipulation and Rogena Brown for secretarial assistance
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Bekesi, J.G., Holland, J.F. (1982). Therapeutic Effectiveness of Neuraminidase-Treated Allogeneic Myeloblasts as Immunogen in Acute Myelocytic Leukemia. In: Mathé, G., Bonadonna, G., Salmon, S. (eds) Adjuvant Therapies of Cancer. Recent Results in Cancer Research, vol 80. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81685-7_8
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DOI: https://doi.org/10.1007/978-3-642-81685-7_8
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