Skip to main content

Part of the book series: Verhandlungen der Deutschen Dermatologischen Gesellschaft ((VDGDERMATOLOGIE,volume 32))

  • 35 Accesses

Abstract

Although more than 4 decades have passed since Behçet defined his triple symptom complex, the exact aetiology and pathogenesis of this process are still undecided. The oral, genital and ocular manifestations initially described have since been extended to include skin, joints, brain, blood vessels, intestine, heart, lungs and kidneys as well [4, 11].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Alm L, Oberg L (1945) Djugorsok Vid SR Behçet’s syndrome. Nord Med 25: 603–604

    Google Scholar 

  2. Askenase PW (1977) Role of basophils, mast cells, and vasoamines in hypersensitivity reactions with a delayed time course. Prog Allergy 23: 199–320

    PubMed  CAS  Google Scholar 

  3. Behçet H (1937) Über rezidivierende, aphthöse, durch einen Virus verursachte Geschwüre am Mund, am Auge und an den Genitalien. Dermatol Wochenschr 105: 1152–1157

    Google Scholar 

  4. Berlin C (1960) Behçet’s disease as a multiple symptom complex: report of ten cases. Arch Dermatol 82: 73–79

    Article  Google Scholar 

  5. Chajek T, Fainaru M (1973) Behçet’s disease with decreased fibrinolysis and superior vena caval occlusion. Br Med J 1: 782–783

    Article  PubMed  CAS  Google Scholar 

  6. Cunliffe WJ (1969) An association between cutaneous vasculitis and decreased blood fibrinolytic activity. Lancet 1: 1239–1240

    Article  PubMed  CAS  Google Scholar 

  7. Denman AM, Pinder M (1974) Measurement of immunological function in man: Interaction between virus and human leukocytes. Proc Roy Soc Med 67: 1219–1221

    PubMed  CAS  Google Scholar 

  8. Dvorak HF (1976) Cutaneous basophil hypersensitivity. J Allerg Clin Immunol 58: 229–240

    Article  CAS  Google Scholar 

  9. Dvorak HF, Dvorak AM (1972) Basophils mast cells and cellular immunity in animals and man. Human Pathol 3: 454–456

    Article  CAS  Google Scholar 

  10. Evans HD, Pallis GA, Spillane JD (1959) Involvement of nervous system in Behçet’s syndrome. Report of three cases and isolation of virus. Lancet II: 349–353

    Google Scholar 

  11. Haim S (1970) Behçet’s syndrome as a generalized systemic disease. Harefuah 78: 63–65

    PubMed  CAS  Google Scholar 

  12. Haim S, Gideoni O, Barzilai A (1977) The histocompatibility antigens in patients with Behçet’s disease. Acta Derm Venereol (Stockh) 57: 243–245

    CAS  Google Scholar 

  13. Haim S, Gilhar A, Mekori T, Segal R (1979) Leucocyte migration inhibition in Behçet’s disease. Dermatologica 159: 302–306

    Article  PubMed  CAS  Google Scholar 

  14. Haim S, Mekori T, Sobel JD, Robinson E (1976) Aspects of lymphocyte function in Behçet’s disease. Dermatologica 153: 34–37

    Article  PubMed  CAS  Google Scholar 

  15. Haim S, Sobel JD, Friedman-Birnbaum R (1974) Thrombophlebitis. A cardinal symptom of Behçet’s disease. Acta Derm Venereol (Stockh) 54: 299–301

    CAS  Google Scholar 

  16. Haim S, Sobel JD, Friedman-Birnbaum R, Lichtig C (1976) Histological and direct immunofluorescence study of cutaneous hyperreactivity in Behçet’s disease. Br J Dermatol 95: 631–636

    Article  PubMed  CAS  Google Scholar 

  17. Kawachi-Takahashi S, Takahashi M, Kogura M, Kawashima T (1974) Elevation of serum C9 level associated with Behçet’s disease. Jap J Exp Med 44: 485–487

    Google Scholar 

  18. Kogure M, Shimada K, Hara HG (1971) Complement titer in patients with Behçet’s disease. Acta Soc Ophthal Jap 75: 1260–1268

    PubMed  CAS  Google Scholar 

  19. Lehner T (1967) Stimulation of lymphocyte transformation by tissue homogenates in recurrent oral ulcerations Immunology 13: 159–166

    PubMed  CAS  Google Scholar 

  20. Lehner T (1969) Characterization of mucosal antibodies in recurrent aphthous ulceration and Behçet’s syndrome. Arch Oral Biol 14: 843–853

    Article  PubMed  CAS  Google Scholar 

  21. Lehner T (1972) Immunological aspects of recurrent oral ulcers. Oral Surg 23: 80–85

    Article  Google Scholar 

  22. Lehner T (Ref. 10) Immunological aspects of Behçet’s syndrome, pp 203–211

    Google Scholar 

  23. Levinsky RJ, Lehner T (1978) Circulating soluble immune complexes in recurrent oral ulceration and Behçet’s syndrome. Clin Exp Immunol 32: 193–198

    PubMed  CAS  Google Scholar 

  24. Lichtig C, Haim S, Gilhar A, Hammel I, Ludatscher R (in press) Mast cells in Behçet’s disease: Ultrastructural and histamine content studies. Dermatologica

    Google Scholar 

  25. Lichtig C, Haim S, Hammel I, Friedman-Birnbaum R (1980) The quantification and significance of mast cells in Behçet’s disease. Br J Dermatol 102: 255–259

    Article  PubMed  CAS  Google Scholar 

  26. Matsumura N, Mizushima Y (1975) Leucocyte movement and colchicine treatment in Behçet’s disease (letter). Lancet 11: 813

    Article  Google Scholar 

  27. Nishiyama S, Murakami M, Hori Y (Ref. 10) The etiological role of organic chloride in Behçet’s disease, p 60

    Google Scholar 

  28. O’Duffy JD, Corney JA, Deodhar S (1971) Behçet’s disease: report of 10 cases, 3 with new manifestations. Ann Intern Med 75: 561–570

    PubMed  Google Scholar 

  29. Ohno S, Nakayama E, Sugiura S, Itakura K, Aoki K, Aizawa M (1975) Specific histocompatibility antigens associated with Behçet’s disease. Am J Ophthal 80: 636–640

    Google Scholar 

  30. Ohno S, Aoki K, Sugiora S, Nakayama E, Itakura K, Aizawa M (1973) HL-A5 and Behçet’s disease (letter). Lancet 11: 1383

    Article  Google Scholar 

  31. Oshima Y, Shimzu T, Yokohari R, Matsumato T, Kano K, Kugami T, Nagaya H, Marugama R (1963) Clinical study on Behçet’s syndrome. Ann Rheum Dis 22: 36–45

    Article  PubMed  CAS  Google Scholar 

  32. Rogers RS, Sams WM, Shorter RG (1974) Lymphocytotoxicity in recurrent aphthous stomatitis. Lymphocytotoxicity for oral epithelial cells in recurrent aphthous stomatitis and Behçet’s disease. Arch Dermatol 109: 361–363

    Article  PubMed  Google Scholar 

  33. Rubenstein LJ, Urich H (1963) Meningoencephalitis of Behçet’s disease. Case report with pathological findings. Brain 86: 151–160

    Article  Google Scholar 

  34. Sezar N (1953) Isolation of virus as a cause of Behçet’s disease. Am J Ophthal 36: 301–315

    Google Scholar 

  35. Shimizu K, Ishikawa S, Miyata M, Yoshida H, Kubo H (Ref. 10) Relationships between the changes of serum copper levels and ocular attacks in Behçet’s disease (an etiological consideration), pp 61–72

    Google Scholar 

  36. Shishido A (1976) Nucleocapsid like structures in the tissues of Behçet’s disease patients. Jap J Med Sci Biol 29: 99–104

    PubMed  Google Scholar 

  37. Shishido A, Yamanouchi K (1979) Viriological studies on etiology of Behçet’s disease in Japan. In: Dillen N, Koniç M, Ovül C (eds) Behçet’s disease. International Congress Series 467, Excerpta Medica, Amsterdam Oxford, pp 73–76

    Google Scholar 

  38. Sobel JD, Haim S, Obedeanu N, Meshulam T, Merzbach D (1977) Polymorphonuclear leucocyte function in Behçet’s disease. Clin Pathol 30: 250–253

    Article  CAS  Google Scholar 

  39. Sugiura S, Aoki K, Fujika K, Kono M (1972) Serum antibodies to various pathogenic agents and lymphocytic transformation in Behçet’s disease. Acta Soc Ophthal Jap 76: 635–641

    PubMed  CAS  Google Scholar 

  40. Williams BD, Lehner T (1977) Immune complexes in recurrent oral ulceration and Behçet’s syndrome. Br Med J 1: 1387–1390

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Haim, S. (1981). Etiopathogenesis of Mucocutaneous Lesions in Behçet’s Disease. In: Christophers, E., Goos, M. (eds) XXXII. Tagung gehalten in Westerland/Sylt vom 16. bis 20. September 1980. Verhandlungen der Deutschen Dermatologischen Gesellschaft, vol 32. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81671-0_95

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-81671-0_95

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-10909-9

  • Online ISBN: 978-3-642-81671-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics