Brief Introduction to Cushing’s Syndrome and Disease

  • Dorothy T. Krieger
Part of the Monographs on Endocrinology book series (ENDOCRINOLOGY, volume 22)


Harvey Cushing’s classic monograph, The Basophil Adenomas of the Pituitary Body and Their Clinical Manifestations, was published in 1932. However, he first described a patient with this disease in 1912, characterizing it as a peculiar polyglandular syndrome including painful obesity, hypertrichosis, and amenorrhea, with overdevelopment of secondary sexual characteristics. At that time, he noted that, “whether these symptoms were chiefly attributable to disordered pituitary, adrenal, pineal or ovarian influences was uncertain.” Cushing’s description of the disease included all of those physical features which today we recognize as being classical. It is also of interest that a follow-up of the patient over a period of 22 years following the onset of the disease noted her to be in “reasonably good health, though some of the stigmata of her malady still persist.”


Pituitary Adenoma Central Nervous System Tumor Adrenal Adenoma Plasma ACTH Level Adrenal Carcinoma 
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Copyright information

© Springer-Verlag Berlin, Heidelberg 1982

Authors and Affiliations

  • Dorothy T. Krieger
    • 1
  1. 1.Division of EndocrinologyThe Mount Sinai Medical CenterNew YorkUSA

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