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Hair Research pp 420-423 | Cite as

Curly Hair as Presenting Symptom in Giant Axonal Neuropathy

  • W. Gebhart
  • E. Sluga
  • K. Toifl

Abstract

Giant Axonal Neuropathy (GAN) is a chronic progressive peripheral polyneuropathy of unknown etiology. Symptoms such as weakness of distal muscles, loss of reflexes and sensation or nystagmus appear usually at the age of 2 or 3 years. With regard to the pathomorphology of the disease, it is characterized by segmental swelling of myelinated and unmyelinated axons in peripheral nerves. Ultrastructural investigations have disclosed, that this enlargement of axons is produced by accumulation of tightly packed filaments with a diameter of approximately 100 Å (Asbury et al. 1972, Carpenter et al. 1974, Igisu et al. 1975, Prineas et al. 1976, Gambarelli et al. 1977, Peiffer et al. 1977, Jedrzejowska et al. 1977).

Keywords

Schwann Cell Sural Nerve Hair Shaft Unmyelinated Axon Osmic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Asbury AK, Gale MK, Cox SC, Baringer JR, Berg BO (1972) Giant axonal neuropathy - a unique case with segmental neurofilamentous masses. Acta Neuropathol 20:237–247PubMedCrossRefGoogle Scholar
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Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • W. Gebhart
    • 1
    • 2
    • 3
  • E. Sluga
    • 1
    • 2
    • 3
  • K. Toifl
    • 1
    • 2
    • 3
  1. 1.Department of Dermatology IIUniversity of ViennaWienAustria
  2. 2.Department of NeuropathologyUniversity of ViennaWienAustria
  3. 3.Department of NeurologyUniversity of ViennaWienAustria

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