Abstract
Since the endocrine organs seem unduly susceptible to auto-immune disorders, one might have expected that the anterior pituitary would not be excluded from such lesions. This has indeed been the case, although auto-immune hypophysitis has (so far) appeared to be a rare disorder. Lymphoid involvement of the pituitary was observed as early as 1953, but auto-immune processes were not suspected (Rapp and Pashkis 1953). The first patient in whom there was a suspicion of this condition was reported by Goudie and Pinkerton (1962); they described a young woman, aged 22, who died of a peripheral vascular collapse following removal of a gangrenous appendix. She had felt fatigued following the birth of a second child 14 months previously, and had had only two scanty menstrual periods between that time and her subsequent death. She also had been found to have an enlarging goitre, and had been treated with thyroid therapy. At autopsy, her very large goitre was proven to result from Hashimoto’s thyroiditis. A shrunken anterior pituitary gland was discovered; histology of the latter showed extensive lymphocytic infiltration of the anterior pituitary surrounding atrophic pituitary cells. Goudie and Pinkerton proposed that the coexistence of the lymphocytic hypophysitis and Hashimoto’s thyroiditis might well be explained by an auto-immune mechanism. Goudie (1968) again discussed this proposal.
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References
Bottazzo GF, Florin-Christensen A, Doniach D (1974) Islet cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet 2: 1279–1283
Bottazzo GF, Pouplard A, Florin-Christensen A, Doniach D (1975) Autoantibodies to prolactin-secreting cells of the human pituitary. Lancet 2: 97–101
Bottazzo GF, Doniach D (1978) Pituitary autoimmunity: a review. Proc R Soc Med 71: 433–436
Bottazzo GF, McIntosh C, Stanford W, Preece M (1980) Growth hormone cell antibodies and partial growth hormone deficiency in a girl with Turner’s syndrome. Clin Endocrinol (Oxf) 12: 1–9
Doniach I (1977) Histopathology of the anterior pituitary. Clin Endocrinol Metab 6: 21–52
Egloff B, Fischbacher W, Von Goumoens E (1969) Lymphomatose Hypophysitis mit Hypophyseninsuffizienz. Schweiz Med Wochenschr 42: 1499–1502
Gleason TH, Stebbins PL, Shanahan MF (1978) Lymphoid hypophysitis in a patient with hypoglycemic episodes. Arch Pathol Lab Med 192: 46–48
Goudie RB (1968) Anterior hypophysitis associated with autoimmune disease. Proc R Soc Med 61: 275
Goudie RM, Pinkerton RH (1962) Anterior hypophysitis and Hashimoto’s thyroiditis in a young woman. J Pathol Bacteriol 83: 584–585
Goust JM, Moulias R, Reinert P, Deville-Chabrolle A, Buffet C, Muller-Berat CN (1972) Cellular immunity to antigens of the organs in endocrine disease. Studies of the leukocyte migration test. Rev F Endocrinol Clin 13: 410–411
Hume R, Roberts GH (1967) Hypophysitis and hypopituitarism; report of a case. Br Med J 2: 548–550
Kiaer W, Rytter Norgaard JO (1969) Granulomatous hypophysitis and thyroiditis with lymphocytic adrenalitis. Acta Pathol Microbiol Scand 76: 229–238
Lack EE (1975) Lymphoid “hypophysitis” with end organ insufficiency. Arch Pathol 99: 215–219
Levine S (1967) Allergic adrenohypophysitis: new experimental disease of the pituitary gland. Science 158: 1190–1191
Ludwig H, Schernthaner G (1978) Multiorganspezifische Autoimmunität bei idiopathischer Nebennierenrindeninsuffizienz. Wien Klin Wochenschr 90: 736–741
Mori T, Kato H, Tatsumi S, Igarashi T, Takayama H (1978) Anti-TSH autoantibody in a patient with Sheehan’s syndrome and chronic thyroiditis. 6th Asia and Oceania Congr Endocrinol, Singapore, January 22–27, 1978, Abstract 125 (to be published)
Rapp JJ, Pashkis KE (1953) Panhypopituitarism with idiopathic hypoparathyroidism. Ann Intern Med 39: 1103–1107
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© 1981 Springer-Verlag Berlin, Heidelberg
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Volpé, R. (1981). Auto-immunity of the Anterior Pituitary. In: Auto-immunity in the Endocrine System. Monographs on Endocrinology, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81624-6_4
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DOI: https://doi.org/10.1007/978-3-642-81624-6_4
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