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Available Data from Carminomycin Studies in the United States: The Acute Intermittent Intravenous Schedule

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New Drugs in Cancer Chemotherapy

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 76))

Abstract

Carminomycin is an anthracycline antitumor antibiotic isolated from the mycelia of Actinomadura carminata [5]. The structure of carminomycin is presented in Fig. 1. Carminomycin is steriochemically quite similar to daunorubicin. The molecule differs from daunorubicin in the aglycone, being a desmethyl daunomycin. Carminomycin is active in a variety of animal tumor systems including L1210 and sarcoma 180 [9]. Antitumor activity does not appear to be schedule dependent in L1210 [2]. Carminomycin is orally absorbed, and the ratio of the LD50 of oral to intravenous administration is 2 : 1 in mice.

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References

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Author information

Authors and Affiliations

  1. The Department of Medicine, Suny Upstate Medical Center, USA, Syracuse, NY

    R. L. Comis, S. J. Ginsberg, S. D. Reich, L. H. Baker & S. T. Crooke

Authors
  1. R. L. Comis
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  2. S. J. Ginsberg
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  3. S. D. Reich
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  4. L. H. Baker
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  5. S. T. Crooke
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Editor information

Editors and Affiliations

  1. Northern California Cancer Program, 1801 Page Mill Road, Suite 200, Building B, Palo Alto, CA, 94304, USA

    Stephen K. Carter

  2. Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Kami-Ikebukuro 1-37-1, Toshima-ku, Tokyo 170, Japan

    Yoshi Sakurai

  3. Institute of Microbial Chemistry, 14-23 Kamiosaki 3-Chome, Shinagawa-ku, Tokyo 141, Japan

    Hamoa Umezawa

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© 1981 Springer-Verlag Berlin Heidelberg

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Comis, R.L., Ginsberg, S.J., Reich, S.D., Baker, L.H., Crooke, S.T. (1981). Available Data from Carminomycin Studies in the United States: The Acute Intermittent Intravenous Schedule. In: Carter, S.K., Sakurai, Y., Umezawa, H. (eds) New Drugs in Cancer Chemotherapy. Recent Results in Cancer Research, vol 76. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81565-2_3

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  • DOI: https://doi.org/10.1007/978-3-642-81565-2_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81567-6

  • Online ISBN: 978-3-642-81565-2

  • eBook Packages: Springer Book Archive

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