Available Data from Carminomycin Studies in the United States: The Acute Intermittent Intravenous Schedule

  • R. L. Comis
  • S. J. Ginsberg
  • S. D. Reich
  • L. H. Baker
  • S. T. Crooke
Conference paper
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 76)

Abstract

Carminomycin is an anthracycline antitumor antibiotic isolated from the mycelia of Actinomadura carminata [5]. The structure of carminomycin is presented in Fig. 1. Carminomycin is steriochemically quite similar to daunorubicin. The molecule differs from daunorubicin in the aglycone, being a desmethyl daunomycin. Carminomycin is active in a variety of animal tumor systems including L1210 and sarcoma 180 [9]. Antitumor activity does not appear to be schedule dependent in L1210 [2]. Carminomycin is orally absorbed, and the ratio of the LD50 of oral to intravenous administration is 2 : 1 in mice.

Keywords

Toxicity HPLC Europe Creatinine Adenocarcinoma 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • R. L. Comis
    • 1
  • S. J. Ginsberg
    • 1
  • S. D. Reich
    • 1
  • L. H. Baker
    • 1
  • S. T. Crooke
    • 1
  1. 1.The Department of MedicineSuny Upstate Medical CenterSyracuseUSA

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