Available Data from Carminomycin Studies in the United States: The Acute Intermittent Intravenous Schedule
Carminomycin is an anthracycline antitumor antibiotic isolated from the mycelia of Actinomadura carminata . The structure of carminomycin is presented in Fig. 1. Carminomycin is steriochemically quite similar to daunorubicin. The molecule differs from daunorubicin in the aglycone, being a desmethyl daunomycin. Carminomycin is active in a variety of animal tumor systems including L1210 and sarcoma 180 . Antitumor activity does not appear to be schedule dependent in L1210 . Carminomycin is orally absorbed, and the ratio of the LD50 of oral to intravenous administration is 2 : 1 in mice.
KeywordsToxicity HPLC Europe Creatinine Adenocarcinoma
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