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Current Status of Nitrosoureas Under Development in Japan

  • Conference paper
New Drugs in Cancer Chemotherapy

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 76))

Abstract

Three nitrosourea compounds [1–4], BCNU, CCNU, and methyl CCNU (MeCCNU) have demonstrated clinical efficacy in a variety of human malignancies including lung cancer, gastrointestinal tumors, lymphomas, melanomas, and brain tumors. But delayed and cumulative hematologic toxicity has been an obstacle to clinical use.

This study was supported partially by NCI contract N01-CM-22054 in the United States and by a grant from the Ministry of Health and Welfare 52-12 in Japan

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Author information

Authors and Affiliations

  1. Division of Clinical Chemotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Kami-Ikebukuro 1-37-1, Toshima-ku, Tokyo 170, Japan

    M. Ogawa & S. Fujimoto

Authors
  1. M. Ogawa
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  2. S. Fujimoto
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Editor information

Editors and Affiliations

  1. Northern California Cancer Program, 1801 Page Mill Road, Suite 200, Building B, Palo Alto, CA, 94304, USA

    Stephen K. Carter

  2. Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Kami-Ikebukuro 1-37-1, Toshima-ku, Tokyo 170, Japan

    Yoshi Sakurai

  3. Institute of Microbial Chemistry, 14-23 Kamiosaki 3-Chome, Shinagawa-ku, Tokyo 141, Japan

    Hamoa Umezawa

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© 1981 Springer-Verlag Berlin Heidelberg

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Ogawa, M., Fujimoto, S. (1981). Current Status of Nitrosoureas Under Development in Japan. In: Carter, S.K., Sakurai, Y., Umezawa, H. (eds) New Drugs in Cancer Chemotherapy. Recent Results in Cancer Research, vol 76. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81565-2_10

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  • DOI: https://doi.org/10.1007/978-3-642-81565-2_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81567-6

  • Online ISBN: 978-3-642-81565-2

  • eBook Packages: Springer Book Archive

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