Structure and Nucleotide Sequence of the Cytochrome B Gene in Yeast Mitochondrial DNA
The mitochondrial respiratory chain contains two distinct cytochromes of the b type (bk and bt). Cytochromes bk and bt differ in their redox potentials and absorption properties in the visible spectrum (Table 1). Both cytochromes are part of the coenzyme QH2-cytochrome c reductase and have been implicated to function on the main pathway of the electron transport chain (Rieske, 1976). Despite the fact that cytochrome b has been isolated from fungal (Weiss and Ziganke, 1974) and mammalian (VonJagow et al., 1978) sources, the relationship of the purified protein to cytochromes bk and bt has not been satisfactorily resolved and until recently it was not clear whether they represent two different or a single heme protein.
KeywordsGlutamic Acid tRNA
Unable to display preview. Download preview PDF.
- Chance B, Wilson DF, Dutton PL, Erecinska M (1970) Energy-coupling mechanisms in mitochondria: Kinetic spectroscopic and thermodynamic properties of an energytransducing form of cytochrome b. Proc Natl Acad Sci USA 66: 1175–1182Google Scholar
- Church GM, Gilbert W (1980) Yeast mitochondrial intron products required in trans for RNA splicing. In: Joseph DR, Schultz J, Scott WA, Werner R (eds) Mobilization and reassembly of genetic information. Academic Press, London New York, in pressGoogle Scholar
- Claisse ML, Spyridakis A, Wambier-Kluppel ML, Pajot P, Slonimski PP (1978) Analysis of proteins translated from the box region. In: Bacila M, Horecker BL, Stoppani AOM (eds) Biochemistry and genetics of yeast: Pure and applied aspects. Academic Press, London New York, pp. 369–390Google Scholar
- Dujon B (1980) Nucleotide sequences of the intron and flanking exons of the mitochondrial 21S rRNA gene of yeast strains with different alleles at the omega and ribl genetic loci. Cell submitted for publicationGoogle Scholar
- Grivell LA, Arnberg AC, Boer PH, Borst P, Bos JL, van Bruggen EFJ, Groot GSP, Hecht NB, Hensgens LAM, van Ommen GJB, Tabak HF (1979) Transcripts of yeast mitochondrial DNA and their processing. In: Cummings DJ, Borst P, Dawid IB, Weissman SM, Fox CF (eds) Extrachromosomal DNA: ICN-UCLA symposia on molecular and cellular biology, vol XV. Academic Press, London New York, pp 305–324Google Scholar
- Jacq C, Lazowska J, Slonimski PP (1980) Sur un nouveau mecanism de la regulation de l’expression genetique. CR Acad Sci Paris Ser D t290: 1–4Google Scholar
- Nobrega FG, Tzagoloff A (1980a) Complete restriction map of the cytochrome b region on mitochondrial DNA in Saccharomyces cereVisiae D273–10B. J Biol Chem submitted for publicationGoogle Scholar
- Nobrega FG, Tzagoloff A (1980b) DNA sequence and organization of the cytochrome b gene in Saccharomyces cereVisiae D273–10B. J Biol Chem submitted for publicationGoogle Scholar
- Slonimski PP, Pajot P, Jacq C, Foucher M, Perrodin G, Kochko A, Lamouroux A (1978) Genetic, physical and complementation maps of the box region. In: Bacila M, Horecker BL, Stoppani AOM (eds) Biochemistry and genetics of yeast: Pure and applied aspects. Academic Press, London New York, pp 339–368Google Scholar