Preferential Vulnerability of Dendrites to Lithium Ion in Rat Brain and in Nerve Cell Culture

  • Zoltan Janka
  • I. Szentistvanyi
  • A. Juhasz
  • E. Kiraly
  • A. Parducz
  • F. Joo
Part of the Acta Neuropathologica Supplementum book series (NEUROPATHOLOGIC, volume 7)


Preferential swelling and vacuolation of dendrites were observed electron microscopically in different brain regions of rats treated with LiCl in a dose of 6–18 mmol/kg for 1–6 days. The most severe fine structural changes were revealed in the hippocampus. Low-dose (0.33 mmol/kg) lithium treatment lasting for a year did not cause any morphologically detectable alterations in the rat brain. In vitro studies showed a reduction of den-dro-axonal process network of neurons measured by morphometric means after lithium exposure. Using different cultures of neuronal and glial cell populations, higher lithium uptake was observed for neuron-enriched cultures.

Key words

lithium dendrites cell culture electron microscopy 


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Copyright information

© Springer-Verlag Berlin, Heidelberg 1981

Authors and Affiliations

  • Zoltan Janka
    • 1
  • I. Szentistvanyi
    • 2
  • A. Juhasz
    • 2
  • E. Kiraly
    • 3
  • A. Parducz
    • 4
  • F. Joo
    • 4
  1. 1.Department of Neurology and PsychiatryUniversity Medical School, SzegedSzegedHungary
  2. 2.Department of Neurology and PsychiatrySzegedHungary
  3. 3.Department of AnatomyUniversity Medical SchoolSzegedHungary
  4. 4.Laboratory of Molecular Neurobiology, Institute of BiophysicsBiological Research CenterSzegedHungary

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