Abstract
We have demonstrated that splenic lymphocytes from normal syngeneic animals can stimulate tumor growth. This effect is T-cell dependent. Preincubation of these lymphocytes with thymosin not only blocks facilitated tumor growth but can induce a significant reduction of local tumor growth and number of pulmonary metastases. Furthermore, thymosin can also block the expression of suppressor activity of lymphocytes either stimulated by Con A or originating from various advanced solid tumor bearing patients. These results therefore suggest that thymosin is able to modulate, directly or indirectly, functional expression of suppressor cells.
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© 1980 Springer-Verlag Berlin Heidelberg
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Serrou, B., Cupissol, D., Caraux, J., Thierry, C., Rosenfeld, C., Goldstein, A.L. (1980). Ability of Thymosin to Decrease in Vivo and in Vitro Suppressor Cell Activity in Tumor Bearing Mice and Cancer Patients. In: Mathé, G., Muggia, F.M. (eds) Cancer Chemo- and Immunopharmacology. Recent Results in Cancer Research, vol 75. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81491-4_18
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DOI: https://doi.org/10.1007/978-3-642-81491-4_18
Publisher Name: Springer, Berlin, Heidelberg
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