Synthesis, Biologic Effects, and Biochemical Properties of Some 2’-Azido- and 2’-Amino-2’-Deoxyarabinofuranosyl Pyrimidines and Purines

  • M. Bobek
  • Y.-C. Cheng
  • E. Mihich
  • A. Bloch
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 74)


Various 2’-azido- and 2’-aminoarabinofuranosyl purine and pyrimidine nucleosides have been synthesized. Among these, the derivatives of cytosine and of adenine inhibit the growth of some tumor cell lines in vitro and in vivo. 2’-Azidoarabinofuranosyl cytosine also interferes with the replication of herpes simplex virus types I and II. Whereas 2’-azidoara-C is resistant to deamination by a partially purified CdR deaminase from KB cells, the adenine derivatives are substrates for aminohydrolases partially purified from calf and mouse intestines. Both azido- and aminoara-C are phosphorylated by partially purified CdR kinases from leukemia L1210 and from human AML blast cells. The accumulated data encourage exploration of the clinical utility of the more potent of these analogues.


Herpes Simplex Virus Type L1210 Cell Adenosine Deaminase Acute Myelocytic Leukemia Cell Azido Group 
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© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • M. Bobek
  • Y.-C. Cheng
  • E. Mihich
  • A. Bloch

There are no affiliations available

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