Abstract
The antioestrogen tamoxifen (TAM) has been shown to be an effective compound in the endocrine therapy of postmenopausal patients with advanced breast cancer. The overall remission rate observed has been found to be 35%–45% in several studies, depending on whether patients have previously received endocrine therapy (Kiang and Kennedy, 1977; Mouridsen, et al., 1978; Moseson, et al., 1978). This value compares well with that found with other modes of endocrine therapy. A definite advantage of TAM treatment over other forms of endocrine therapy is that side effects are very few and are mild in character (Mouridsen et al., 1978).
Workers at the Fibiger Laboratory were sponsored by the Danish Cancer Society.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Dæhnfeldt, J. L., Briand, P.: Determinations of high-affinity gestagen receptors in hormone-responsive and hormone-independent GR mouse mammary tumors by an exchange assay. In: Progesterone receptors in normal and neoplastic tissues. McGuire, W. L., Raynaud, J. P., Baulien, E.-E. (eds.), p. 59. New York: Raven Press 1977
Hayward, J. L., Carbone, P. P., Heuson, J.-C., Kumaoka, S., Segaloff, A., Reubens, R. D.: Assessment of response to therapy in advanced breast cancer. Eur. J. Cancer 13, 89–94 (1977)
Heuson, J. C., Longeval, E., Mattheiem, W. H., Deboel, M. C., Sylvester, R. J., Leclercq, G.: Significance of quantitative assessment of estrogen receptors for endocrine therapy in advanced breast cancer. Cancer 39, 1971–1977 (1977)
Horwitz, K. V., McGuire, W. L.: Estrogen and progesterone: their relationship in hormone-dependent breast cancer. In: Progesterone receptors in normal and neoplastic tissues. McGuire, W. L. et al. (eds.), p. 103. New York: Raven Press 1977
Jensen, E. V.: Estrogen receptors in hormone-dependent breast cancers. Cancer Res. 35, 3362–3364 (1975)
Jensen, E. V., Block, G. E., Smith, S., Kyser, K., Desombre, E. R.: Estrogen receptors and breast cancer response to adrenalectomy. Natl. Cancer Inst. Monogr. 34, 55–70 (1971)
Jensen, E. V., Polley, T. Z., Smith, S., Block, G. E., Ferguson, D. J., Desombre, E. R.: Prediction of hormone dependency in human breast cancer. In: Estrogen receptors in human breast cancer., McGuire, W. L., Carbone, P. P., Vollmer, E. P. (eds.), p. 37. New York: Raven Press 1975
Kiang, D. T., Kennedy, B. J.: Tamoxifen (antiestrogen) therapy in advanced breast cancer. Ann. Intern. Med. 87, 687–690 (1977)
Laing, L., Smith, M. G., Calman, K. C., Smith, D. C., Leake, R. E.: Nuclear oestrogen receptors and treatment of breast cancer. Lancet 1977 II, 168–169
Lippman, M. E., Allegra, J. C., Thompson, E. B., Simon, R., Barlock, A., Green, L., Huff, K. K., Do, H. M. T., Aitken, S. C., Warren, R.: The relation between estrogen receptors and respone rate to cytotoxic chemotherapy in metastatic breast cancer. N. Engl. J. Med. 298, 1223–1228 (1978)
Maass, H., Engel, B., Trams, G.: Steroid hormone receptors in human breast cancer and the clinical significance. J. Steroid Biochem. 6, 743–749 (1975)
McGuire, W. L., Pearson, O. H., Segaloff, A.: Predicting hormone responsiveness in human breast cancer. In: Estrogen receptors in human breast cancer. McGuire, W. L., Carbone, P. P., Vollmer, E. P. (eds.), p. 17. New York: Raven Press 1975
Morgan, L. R., Jr., Schein, P. S., Woolley, P. V., Hoth, D., Macdonald, J., Lippmann, M., Posey, L. E., Beazley, R. W.: Therapeutic use of tamoxifen in advanced breast cancer: Correlation with biochemical parameters. Cancer Treat. Rep. 60, 1437–1443 (1976)
Moseson, D. L., Sasaki, G. H., Kraybill, W. G., Leung, B. S., Davenport, C. E., Fletcher, W. S.: The use of antiestrogens, tamoxifen and nafoxidine in the treatment of human breast cancer in correlation with estrogen receptor values. Cancer 41, 797–800 (1978)
Mouridsen, H. T., Palshof, T., Patterson, J., Battersby, L.: Tamoxifen — a review of its efficacy in advanced breast cancer. Cancer Treat. Rev. 5, 131–141 (1978)
Mouridsen, H. T., Palshof, T., Rose, C.: Therapeutic effect of tamoxifen alone versus tamoxifen in combination with gestagen or estrogen in advanced breast cancer. In: Endocrine treatment of breast cancer — A new approach. Henningsen, B., Linder, F., Steichele, C. (eds.), p. 169–177. Berlin, Heidelberg, New York: Springer 1980
Nenci, I., Beccati, M. D., Piffanelli, A., Lanza, G.: Detection and dynamic localisation of estradiol-receptor complexes in intact target cells by immunofluorescence technique. J. Steroid Biochem. 7, 505–510 (1976)
Pertschuk, L. P.: Detection of estrogen binding in human mammary carcinoma by immunofluorescence: a new technique utilizing the binding hormone in a polymerized state. Res. Commun. Chem. Pathol. Pharmacol. 14, 771–114 (1976)
Savlov, E. D., Wittliff, J. L., Hilf, R.: Further studies of biochemical predictive tests in breast cancer. Cancer 39, 539–541 (1977)
Sluyser, M., Van Nie, R.: Estrogen receptor content and hormone-responsive growth of mouse mammary tumors. Cancer Res. 34, 3253–3257 (1974)
Tormey, D. C., Simon, R. M., Lippman, M. E., Bull, J. M., Myers, C. E.: Evaluation of tamoxifen dose in advanced breast cancer: A progress report. Cancer Treat. Rep. 60, 1451–1459 (1976)
Ward, W. W. C.: Combined antiprolactin and antiestrogen therapy for breast carcinoma. Clin. Oncol. 3, 91–95 (1977)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Rose, C., Thorpe, S.M., Løber, J., Dænfeldt, J.L., Palshof, T., Mouridsen, H.T. (1980). Therapeutic Effect of Tamoxifen Related to Estrogen Receptor Level. In: Henningsen, B., Linder, F., Steichele, C. (eds) Endocrine Treatment of Breast Cancer. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 71. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81406-8_19
Download citation
DOI: https://doi.org/10.1007/978-3-642-81406-8_19
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-81408-2
Online ISBN: 978-3-642-81406-8
eBook Packages: Springer Book Archive