Abstract
The Swiss Cooperative Oncology Group has had very wide experience of treating patients with advanced breast cancer, both with endocrine and with cytotoxic therapy. The Swiss Group therefore gratefully accepted the opportunity of testing tamoxifen, as a new and promising, nonsteroid hormone-like substance, in a group of patients with metastatic breast cancer, most of whom had already received some anticancer treatment.
Participating member institutions of SAKK were: Onkologische Abteilung, Medizinische Universitätsklinik und -Poliklinik, Kantonsspital, Basel (G. A. Nagel, J. P. Obrecht). Onkologische Abteilung, Inselspital, Bern (K. W. Brunner, R. W. Sonntag). Division d’Oncologie-Hématologie, Clinique médicale universitaire, Hôpital cantonal, Genève (P. Alberto, L. Wagenknecht). Service d’Oncologie, Hôpital des Cadolles, Neuchâtel (P. Siegenthaler). Abteilung für Onkologie und Hämatologie, Medizinische Klinik C, Kantonsspital, St. Gallen (H. J. Senn, W. F. Jungi). Servizio d’Oncologia, Ospedale San Giovanni, Bellinzona (F. Cavalli). Onkologische Abteilung, Medizinische Universitätsklinik, Universitätsspital, Zürich (G. Martz, C. Sauter). Onkologische Station, Medizinische Poliklinik, Kantonsspital Winterthur (T. Kroner). Onkologische Station, Medizinische Klinik, Kantonsspital Luzern (H. J. Schmid, F. Riedler).
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References
Cavalli, F., Alberto, P., Jungi, W. F., Martz, G., Brunner, K. W.: Tamoxifen alone or combined with multiple drug chemotherapy in disseminated breast carcinoma. Proc. 10th Internat. Congress Chemotherapy, Zürich, Vol. II, pp. 1286–1287. Washington: Amer. Soc. Microbiol. 1978
Cole, M. P., Jones, C. T. A., Todd, I. D. H.: A new anti-oestrogenic agent in late breast cancer — an early clinical appraisal of ICI 46474. Br. J. Cancer 25, 210–214 (1971)
Ferrazzi, E., Cartei, G., De Besi, P., Fornasiero, A., Palù, G., Paccagnella, A., Sperandio, P., Fosser, V., Grigoletto, E., Fiorentino, M.: Tamoxifen in disseminated breast cancer. Tumori 63, 463–468 (1977)
Golder, M. P., Phillips, M. E. A., Baum, M., Griffiths, K., Fahmy, D. R., Henk, J. M., Jones, V., Preece, P. E.: Hormones in breast cancer patients on tamoxifen. Br. J. Cancer 32, 246–247 (1975)
Harper, M. J. K., Walpole, A. L.: A new derivative of triphenylethylene: effect on implantation and mode of actions in rats. J. Reprod. Fertil. 13, 101–119 (1967)
Henningsen, B., Amberger, H.: Antiöstrogene Therapie des metastasierenden Mammakarzinoms. Dtsch. Med. Wochenschr. 102, 713–716 (1977)
Heuson, J. C.: Current overview of EORTC clinical trials with tamoxifen. Cancer Treat. Rep. 60, 1463–1466 (1976)
Jordan, V. C.: Antiestrogenic and antitumor properties of tamoxifen in laboratory animals. Cancer Treat. Rep. 60, 1409–1419 (1976)
Jungi, W. F., Alberto, P., Wagenknecht, L., Cavalli, F., Martz, G., Brunner, K. W.: Antiöstrogene: eine neue endokrine Behandlungsmöglichkeit beim metatasierenden Mammakarzinom. Schweiz. Med. Wochenschr. 108, 1317–1321 (1978)
Kiang, D. T., Kennedy, B. J.: Tamoxifen (antioestrogen) therapy in advanced breast cancer. Ann. Intern. Med. 87, 687–690 (1977)
Leclercq, G., Heuson, J. C.: Therapeutic significance of sex-steroid hormone receptors in the treatment of breast cancer. Eur. J. Cancer 13, 1205–1215 (1977)
Legha, S. S., Carter, S. K.: Antiestrogens in the treatment of cancer. Cancer Treat. Rev. 3, 205–216 (1976)
Legha, S. S., Davis, H. L., Muggia, F. M.: Hormonal therapy of breast cancer: new approaches and concepts. Ann. Intern. Med. 88, 69–77 (1978)
Lerner, H. J., Band, P. R., Israel, L., Leung, B. S.: Phase II study of tamoxifen: Report of 74 patients with stage IV breast cancer. Cancer Treat. Rep. 60, 1431–1435 (1976)
Lippman, M.: Hormone-responsive human cancer in continuous tissue culture. In: Breast cancer. Heuson, J. C., Mattheiem, W. H., Rosencweig, M. (eds.), pp. 111–139. New York: Raven Press 1976
Lippman, M., Bolan, G., Huff, K.: Interactions of antiestrogens with human breast cancer in long-term culture. Cancer Treat Rep. 60, 1421–1429 (1976)
Manni, A., Trujillo, J., Marshall, J. S., Pearson, O. H.: Antiestrogen-induced remissions in stage IV breast cancer. Cancer Treat. Rep. 60, 1445–1450 (1976)
Morgan, L. R., Schein, P. S., Wolley, P. V., Hoth, D., MacDonald, J., Lippmann, M., Posey, L. E., Beazley, R. W.: Therapeutic use of tamoxifen in advanced breast cancer. Cancer Treat. Rep. 60, 1437–1443 (1976)
Moseson, D. L., Sasaki, G. H., Kraybill, W. G., Leung, B. S., Davenport, C. E., Fletcher, W. S.: The use of antiestrogens tamoxifen and nafoxidine in the treatment of human breast cancer in correlation with estrogen receptor values. Cancer 41, 797–800 (1978)
Nicholson, R. I., Golder, M. P.: The effects of synthetic antiestrogens on the growth and biochemistry of rat mammary tumors. Eur. J. Cancer 11, 571 (1975)
Nicholson, R. I., Davies, P., Griffith, K.: Effects of oestradiol-17 and tamoxifen on nuclear oestradiol-17 receptors in DMBA-induced rat mammary tumors. Eur. J. Cancer 13, 201–208 (1977)
Nordenskjöld, B., Löwhagen, T., Westerberg, H., Zajicke, J.: 3H-Thymidine incorporation into mammary carcinoma cells obtained by needle aspiration before and during endocrine therapy. Acta Cytol. (Baltimore) 20, 137–143 (1976)
Roberts, M. M., Forrest, A. P. M., Hamilton, T., Langlands, A. O., Lutz, Q., McFayden, J. J., Stewart, H. J.: Preliminary report of a controlled trial in advanced breast cancer comparing tamoxifen with conventional hormone therapy. Cancer Treat. Rep. 60, 1461–1462 (1976)
Sponzo, R. W., Barkley, J. B., Horton, J., Cunningham, T. J.: Tamoxifen in the management of advanced breast cancer. Proc. Am. Assoc. Cancer Res. 17, 68 (1976)
Szepesi, T., Czech, W.: Klinische Beurteilung der Anti-Oestrogensubstanz Tamoxifen in der Behandlung des metastasierenden Mammakarzinoms. Wien. Klin. Wschr. 90, 133–141 (1978)
Tagnon, H. J.: Antiestrogens in treatment of breast cancer. Cancer 39 (Suppl.), 2959–2964 (1977)
Tormey, D. C., Simon, R. M., Lippman, M. J., Bull, J. M., Myers, C. E.: Evaluation of tamoxifen dose in advanced breast cancer: a progress report. Cancer Treat. Rep. 60, 1451–1459 (1976)
Viladiu, R., Bosch, F. X., Benito, E., Alonso, M. C.: Antiestrogen tamoxifen in the treatment of advanced breast cancer: a series of 31 patients. Cancer Treat. Rep. 61, 899–900 (1977)
Ward, H. W. C.: Combined anti-prolactin and anti-oestrogen therapy for breast carcinomas. Clin. Oncol. 3, 1–5 (1977)
Ward, H. W. C.: Anti-oestrogen therapy for breast cancer: a trial of tamoxifen at two dose levels. Br. Med. J. 1978 I, 13–14
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Jungi, W.P., Alberto, P., Cavalli, F. (1980). Tamoxifen in Advanced Breast Cancer: Experience of the SAKK (Schweizerische Arbeitsgruppe für Klinische Krebsforschung — Swiss Cooperative Oncology Group). In: Henningsen, B., Linder, F., Steichele, C. (eds) Endocrine Treatment of Breast Cancer. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 71. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81406-8_18
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