Skip to main content
SpringerLink
Log in
SpringerLink
Log in

Processing of Bacteriophage Proteins

  • Conference paper
Biological Functions of Proteinases

Abstract

Although a wide variety of functions has been discovered for proteases in higher organisms (Reich et al., 1975; Neurath and Walsh, 1976), relatively little is known about their functions in bacteria. The discovery that specific types of limited proteolysis occur during the growth of a number of bacterial viruses has provided an insight into the roles proteases might play in uninfected cells, and a number of experimental systems for investigation of protease function and its regulation in bacteria.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Al-Janabi J, Hartsuck JA, Tang J (1972) Kinetics and mechanism of pepsinogen activation. J Biol Chem 247: 4628–4632

    PubMed  CAS  Google Scholar 

  • Camacho A, Jimenez F, Vinuela E, Salas M (1978) Order of assembly of the lower collar and the tail proteins of Bacillus subtilis bacteriophage ø–29. J Virol 29: 540–545

    Google Scholar 

  • Carrascosa JL, Camacho A, Vinuela E, Salas M (1974) A precursor of the neck appendage protein of B. subtilis phage ø–29. FEBS Lett 44: 317–321

    Article  PubMed  CAS  Google Scholar 

  • Casjens S, King J (1975) Virus assembly. Annu Rev Biochem 44: 555–611

    CAS  Google Scholar 

  • Castillo CJ, Hsiao C, Coon P, Black LW (1977) Identification and properties of bacteriophage T4 capsid-formation gene products. J Mol Biol 110: 585–601

    Article  PubMed  CAS  Google Scholar 

  • Champe SP, Eddleman HL (1967) Polypeptides associated with morphogenic defects in bacteriophage T4. In: Colter JS, Paranchych W (eds) The molecular biology of viruses. Academic Press, London New York, p 55–70

    Google Scholar 

  • Chang CN, Blobel G, Model P (1978) Detection of prokaryotic signal peptidase in an E. coli-membrane fraction: endoproteolytic cleavage of nascent fl precoat protein. Proc Natl Acad Sci USA 75: 361–365

    CAS  Google Scholar 

  • Eerd van JP, Champe SP, Yager L, Kubota I, Tsugita A (1977) Primary structure of internal peptide VII of T-even bacteriophages. J Mol Biol 117: 521–524

    Article  PubMed  Google Scholar 

  • Georgopoulos CP, Hendrix RW, Kaiser AD, Wood WB (1972) Role of the host cell in bacteriophage morphogenesis: effect of a bacterial mutation on T4 head assembly. Nature New Biol 239:38–41

    Google Scholar 

  • Giri JG, McCullough JE, Champe SP (1976) Identification of gene products essential for in vitro formation of the internal peptides of bacteriophage T4. J Virol 13: 419–427

    Google Scholar 

  • Golberg AL (1972) Degradation of abnormal proteins in E. coli. Proc Natl Acad Sci USA 69: 422–426

    Article  Google Scholar 

  • Goldstein R, Lengyel J, Pruss G, Barrett K, Calendar R, Six E (1974) Head size determination and the morphogenesis of satellite phage P4. Curr Top Microbiol Immunol 68: 59–75

    PubMed  Google Scholar 

  • Gottesman S, Zipser D (1978) Deg phenotype of E. coli Ion mutants. J Bacteriol 133: 844–851

    CAS  Google Scholar 

  • Hendrix RW, Casjens S (1974) Protein cleavage in bacteriophage lambda tail assembly. Virology 61: 156–159

    Article  PubMed  CAS  Google Scholar 

  • Hendrix RW, Tsui L-C (1978) Cleavage of gpH in λ tail assembly. Abstr 6th Biennial Conf Bacteriophage Assembly Toronto Canada

    Google Scholar 

  • Hohn T, Katsura I (1977) Structure and assembly of bacteriophage lambda. Curr Top Microbiol Immunol 78: 69–110

    Article  PubMed  CAS  Google Scholar 

  • Hsiao CL, Black LW (1977) DNA packaging and the pathway of bacteriophage T4 head assembly. Proc Natl Acad Sci USA 74: 3652–3656

    Article  PubMed  CAS  Google Scholar 

  • Isobe T, Black LW, Tsugita A (1976a) Primary structure of bacteriophage T4 internal protein II and characterization of the cleavage upon phage maturation. J Mol Biol 102: 349–365

    Article  PubMed  CAS  Google Scholar 

  • Isobe T, Black LW, Tsugita A (1976b) Protein cleavage during virus assembly: a novel specificity of assembly dependent cleavage in bacteriophage T4. Proc Natl Acad Sci USA 73: 4205–4209

    Article  PubMed  CAS  Google Scholar 

  • Isobe T, Black LW, Tsugita A (1977) Complete amino acid sequence of bacteriophage internal protein I and its cleavage site on virus maturation. J Mol Biol 110: 168–177

    Article  Google Scholar 

  • Katsura I, Kùhl PW (1975) Morphogenesis of the tail of bacteriophage lambda. III. Morphogenetic pathway. J Mol Biol 91: 257–273

    Google Scholar 

  • Konings RNH, Hulsebas T, Van den Hondel CA (1975) Identification and characterization of the in vitro synthesized gene products of bacteriophage M13.. J Virol 15: 570–584

    PubMed  CAS  Google Scholar 

  • Kurtz M, Champe S (1977) Precursors of the T4 internal peptides. J Virol 22: 412–419

    PubMed  CAS  Google Scholar 

  • Laemmli UK (1970) Cleavage of structural protein during the assembly of the head of bacteriophage T4. Nature (London) 227: 680–685

    Article  CAS  Google Scholar 

  • Laemmli UK, Favre M (1973) Maturation of the head of bacteriophage T4. I DNA packaging events. J Mol Biol 80: 575–599

    Google Scholar 

  • Laemmli UK, Johnson RA (1973) Maturation of the head of bacteriophage T4. II. Head-related aberrant x-particles. J Mol Biol 80: 601–611

    Google Scholar 

  • Lengyel J, Goldstein R, Marsh M, Sunshine M, Calendar R (1973) Bacteriophage P2 head morphogenesis: cleavage of the major capsid protein. Virology 53: 1–23

    Article  PubMed  CAS  Google Scholar 

  • Martin DTM, Adair C, Ritchie DA (1976) Polypeptides specified by phage T1. J Gen Virol 33: 309–319

    Article  PubMed  CAS  Google Scholar 

  • Murialdo H, Becker A (1978) Phage head morphogenesis. Microbiol Rev 42: 529–576

    PubMed  CAS  Google Scholar 

  • Neurath H, Walsh KA (1976) Role of proteolytic enzymes in biological regulation (a review). Proc Natl Acad Sci USA 73: 3825–3832

    Article  PubMed  CAS  Google Scholar 

  • Onorato L, Showe MK (1975) Gene 21 protein-dependent proteolysis in vitro of purified gene 22 product of bacteriophage T4. J Mol Biol 92: 395–412

    Article  PubMed  CAS  Google Scholar 

  • Onorato L, Stirmer B, Showe MK (1978) Isolation and characterization of T4 mutant preheads. J Virol 27: 409–426

    PubMed  CAS  Google Scholar 

  • Ray P, Murialdo H (1975) The role of gene Nu3 in bacteriophage lambda head morphogenesis. Virology 64: 247–263

    Article  PubMed  CAS  Google Scholar 

  • Reich E, Rifkin DB, Shaw E (1975) Proteases and biological control. Cold Spring Harbor Lab

    Google Scholar 

  • Roberts JW, Roberts CW, Craig NL (1978) E. coli recA gene product inactivates phage λ repressor. Proc Natl Acad Sci USA 75:4714–4718

    Google Scholar 

  • Showe MK (1979a) Limited proteolysis during the maturation of bacteriophage T4. In: Cohen GN, Holzer H (eds) DHEW Publication (NIH)79–1591. US Government Printing Office, Washington DC, 151–155

    Google Scholar 

  • Showe MK (1979b) Bacteriophage protein processing. Curr Top Microbiol Immunol in press

    Google Scholar 

  • Showe MK, Onorato L (1978) A kinetic model for form-determination of the head of bacteriophage T4. Proc Natl Acad Sci USA 75: 4165–4169

    Article  PubMed  CAS  Google Scholar 

  • Showe MK, Isobe E, Onorato L (1976a) Bacteriophage T4 prehead proteinase. I. Purification and properties of a bacteriophage enzyme which cleaves the capsid precursor proteins. J Mol Biol 107: 35–54

    Google Scholar 

  • Showe MK, Isobe E, Onorato L (1976b) Bacteriophage T4 prehead proteinase. II. Its cleavage from the product of gene 21 and regulation in phage-infected cells. J Mol Biol 107: 55–69

    Article  PubMed  CAS  Google Scholar 

  • Simon LD (1972) The infection of E. coli by T2 and T4 bacteriophages as seen in the electron microscope. IV. T4 head morphogenesis. Proc Natl Acad Sci USA 69: 907–911

    CAS  Google Scholar 

  • Smilowitz H, Carson J, Robbins P (1972) Association of newly synthesized major coat protein with infected host cell inner membrane. J Supramol Struct 1: 8–18

    Article  PubMed  CAS  Google Scholar 

  • Steinberg A, Zipser D (1973) The Ion gene and degradation of 3-galactosidase non-sense fragments. J Bacterid 116: 1469–1471

    Google Scholar 

  • Steven AC, Aebi U, Couture E, Showe MK (1976) Structure of T4 polyheads. II. A pathway of polyhead transformations as a model for T4 capsid maturation. J Mol Biol 106: 187–221

    Article  PubMed  CAS  Google Scholar 

  • Tosi ME, Reilly BE, Anderson DL (1975) Morphogenesis of bacteriophage ø–29 of Bacillus subtilis: Cleavage and assembly of the neck appendage protein. J Virol 16: 1282–1295

    Google Scholar 

  • Tsugita A, Black LW, Showe MK (1975) Protein cleavage during virus assembly: characterization of cleavage in T4 phage. J Mol Biol 98: 271–275

    Article  CAS  Google Scholar 

  • Weigle J (1966) Assembly of phage lambda in vitro. Proc Natl Acad Sci USA 55: 1462–1466

    Article  PubMed  CAS  Google Scholar 

  • Witkin E (1976) Ultraviolet mutagenesis and inducible DNA repair in E. coli. Bacteriol Rev 40: 869–907

    CAS  Google Scholar 

  • Zweig M, Cummings DJ (1973) Cleavage of head and tail proteins during bacteriophage T5 assembly: selective host involvement in the cleavage of a tail protein. J Mol Biol 80: 505–518

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biozentrum, Basel University, Klingelbergstraße 70, CH-4056, Basel, Switzerland

    M. K. Showe

Authors
  1. M. K. Showe
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Biochemisches Institut, Albert-Ludwigs-Universität, Hermann-Herder-Straße 7, 7800, Freiburg, Germany

    Helmut Holzer

  2. Lehrstuhl für Biochemie Fakultät für Chemie, Universität Bielefeld, Universitätsstraße, 4800, Bielefeld, Germany

    Harald Tschesche

Rights and permissions

Reprints and permissions

Copyright information

© 1979 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Showe, M.K. (1979). Processing of Bacteriophage Proteins. In: Holzer, H., Tschesche, H. (eds) Biological Functions of Proteinases. Colloquium der Gesellschaft für Biologische Chemie 26.–28. April 1979 in Mosbach/Baden, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81395-5_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-81395-5_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81397-9

  • Online ISBN: 978-3-642-81395-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation