Summary
Thirty patients with metastatic cervical cancer were treated using a sequential combination of bleomycin and mitomycin C. The total remission rate obtained in the patients objectively evaluated was 88.3%, which included a 65.3% complete remission rate and a 23% partial remission rate. No significant difference in response rate was found among the various metastatic sites. The average remission duration in complete responders was about 4.5 months. Without maintenance therapy, they inevitably relapsed. The oral administration of Carboquone (an analogue of mitomycin C) as maintenance therapy inhibited recurrence effectively, but produced several fatal effects such as severe anemia, infection, and intestinal bleeding. Six (20%) of the patients survived these effects and are still alive more than 2 years after the initiation of the therapy.
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References
Miyamoto, T., Watanabe, M., Takabe, Y., Terasima, T.: Effect of ftorafur on metastatic adenocarcinomas and proposal for some principle of single and combined chemotherapy (in Japanese). Gann to Kagaku Ryoho, 3, 1225 (1976)
Miyamoto, T., Takabe, Y., Watanabe, M., Nakagima, Y., Terasima, T.: Combination effect of bleomycin and mitomycin-C on cultured mammalian cells. Proc. Jpn. Cancer Assoc, 36th Annual Meeting. [Abst] 136, 1977
Miyamoto, T., Takabe, Y., Watanabe, M., Terasima, T.: Effectiveness of a sequential combination of bleomycin and mitomycin-C on an advanced cervical cancer. Cancer 41, 403 (1978)
Okada, N., Arakawa, M.: Comparative studies of the antitumor effect on intravenous administration of carbazilquinone and mitomycin-C. Gann 67, 805 (1976)
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© 1980 Springer-Verlag Berlin Heidelberg
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Miyamoto, T. (1980). Recent Results of Using a Sequential Combination of Bleomycin and Mitomycin C in the Treatment of Metastatic Cervical Cancer. In: Carter, S.K., Sakurai, Y. (eds) New Anticancer Drugs. Recent Results in Cancer Research, vol 70. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81392-4_22
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DOI: https://doi.org/10.1007/978-3-642-81392-4_22
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-81394-8
Online ISBN: 978-3-642-81392-4
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