Abstract
The porphyrin biosynthetic pathway carries out heterogeneous functions of haem catalysis: oxygen transport (haemoglobin) and storage (myoglobin), respiration (cytochromes), or in general, biological oxidation, and at least, drug metabolism (cytochrome P-450) [3]. For all these actions protohaem (iron protoporphyrin), which belongs to the porphyrin isomer III series, is required as prosthetic group. Coproporphyrinogen oxidase, a mitochondrial enzyme, can only handle coproporphyrinogen III. Thus, the formation of porphyrinogens of the isomer I type ends at the sequence of coproporphyrin(ogen).
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References
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Doss, M. (1979). Haematological Disturbances of Porphyrin Metabolism. In: Gross, R., Hellriegel, KP. (eds) Strategies in Clinical Hematology. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 69. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81371-9_11
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DOI: https://doi.org/10.1007/978-3-642-81371-9_11
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