Adjuvant Therapy in the Management of Osteosarcoma: Need for Critical Reassessment
Until about 8 years ago, the prognosis for patients with osteosarcomas used to be extremely bad [3, 9, 14] in spite of the fact that the control of the primary tumor is usually achieved. As about 90% of these tumors arise in the long bones of the limbs, ablative surgery can usually be performed as a radical procedure and local recurrences are fairly rare. In some centers, mainly in France, radiotherapy is used as an alternative. As osteosarcomas are rather radioresistant tumors, very high radiation doses are necessary. Even though such treatment regimens sometimes lead to complications in the normal tissues, some local recurrences still do occur. However, both the sequelae and the tumor regrowth can usually be managed without great difficulty with ablative surgery. Although this policy is much more complicated and requires intensive follow-up of the patient, the possibility to preserve the limb in a fraction of the patients merits serious consideration.
KeywordsAdjuvant Therapy Lung Metastasis Appearance Rate Irradiate Patient Ablative Surgery
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