Abstract
The dynamic structural organization of the surface membrane in mammalian cells is now widely accepted and in some cases even well-documented. However, the general term “membrane fluidity” commonly employed in this respect is actually complex and covers different properties of the membrane. The most prominent of these are: (a) the degree of lateral and rotational mobilities of membrane protein receptors [9,22] and (b) the degree of viscosity of the surface membrane lipid core [6, 7, 10, 20]. These dynamic features of the cell surface membrane, which to some extent are interrelated [21], are now believed to play a major role in cellular control mechanisms that determine normal and abnormal cell growth and differentiation [2, 3, 8, 11, 15]. Moreover, since by definition, all membrane protein receptors are embedded to some extent in the membrane lipid core, the dynamic nature or the lipid domain that is determined by its lipid composition may determine to a large extent functional activities of proteins that are embedded in it.
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Rosenfeld, C., Jasmin, C., Mathé, G., Inbar, M. (1979). Dynamic and Composition of Cellular Membranes and Serum Lipids in Malignant Disorders. In: Bonadonna, G., Mathé, G., Salmon, S.E. (eds) Adjuvant Therapies and Markers of Post-Surgical Minimal Residual Disease I. Recent Results in Cancer Research, vol 67. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81320-7_10
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DOI: https://doi.org/10.1007/978-3-642-81320-7_10
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