Advertisement

Testis-Organizing Function of H-Y Antigen

  • Susumu Ohno
Part of the Monographs on Endocrinology book series (ENDOCRINOLOGY, volume 11)

Abstract

The extreme evolutionary conservatism displayed by H-Y antigen is reminiscent of the similar and even more extreme conservatism displayed by histone IV. The very exact and invariant function must have been assigned to H-Y antigen throughout the age of mammals. As far as mammals are concerned, the role of the H-Y antigent almost had to be that of the primary (gonadal) sex determiner. H-Y antigen must have been diverting the emerging gonad’s inherent tendency to develop into an ovary, causing it to organize a testis instead.

Keywords

Sertoli Cell Primordial Follicle Antigen Site Testicular Cell Gonadal Dysgenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Berlin · Heidelberg 1979

Authors and Affiliations

  • Susumu Ohno
    • 1
  1. 1.Department of Biology, City of HopeNational Medical CenterUSA

Personalised recommendations