Why Are a Number of Unlinked Genes Involved in H-Y Antigen Expression ?

  • Susumu Ohno
Part of the Monographs on Endocrinology book series (ENDOCRINOLOGY, volume 11)


The master regulatory gene that occupies the very top of a regulatory hierarchy, by its very definition should not be under the regulatory influence of any other gene. It is true that by forming a feedback loop, any gene can assume the dual role of being at once the regulator and the regulated. This form of genetic regulatory system, however, is likely to operate at the periphery of a given regulatory hierarchy. Organogenesis being one of the earlier events of ontogeny, the role of organogenesis-directing antigen is to trigger the sequential activation of subsidiary regulatory systems, some of which may form feedback loops.


Antigen Expression Antigen Level Marmoset Monkey Unlinked Gene Master Regulatory Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin · Heidelberg 1979

Authors and Affiliations

  • Susumu Ohno
    • 1
  1. 1.Department of Biology, City of HopeNational Medical CenterUSA

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