Advertisement

Chemotherapy in Non-Hodgkin’s Malignant Lymphomas According to Potential Evolutive Groups

  • J. J. Sotto
  • M. Michallet
  • M. F. Sotto
  • B. Lachet
  • H. Martin
  • R. Schaerer
  • C. Vrousos
  • D. Hollard
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 65)

Abstract

Histology and cytology show us the strong heterogeneity of non-Hodgkin’s malignant lymphomas (NHML). Numerous classifications have been proposed. They contain 6–12 classes [18, 25] which more or less match [5, 9, 10, 12, 17, 18, 20, 25]. If, with luck, a nonsophisticated and reproducible classification could predict the evolution, we would have to take it into account and suit the treatment to it. Nevertheless, none of the present classification systems are able to solve the problem for all the patients with NHML. The aim of a practical classification is to clearly distinguish the morphologic groups with the same predictable evolution possibly to cancel those in which the prognosis is still confused. Such well-defined groups have already been described, e.g., African Burkitt’s lymphoma [1], immunoblastic sarcoma [19], convoluted cell lymphosarcoma [18, 30], nodular well-differentiated lymphomas [4, 16], and histiocytosarcoma [22]. Nevertheless, it is still difficult to compare the potential evolution of the morphologic groups from one center to another. There are several causes: the reproducibility is not easy, the treatments are different, and even the frontiers of the disease are badly separated from the chronic lymphocytic leukemia or the acute leukemia.

Keywords

Complete Remission Chronic Lymphocytic Leukemia Acute Leukemia Malignant Lymphoma Cytosine Arabinoside 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Berard, C., O’conor, G. T., Thomas, L. B., Torloni, H.: Histopathological definition of Burkitt’s tumour. Bull. W.H.O.,40, 601 (1969)Google Scholar
  2. 2.
    Bonnadonna, G., De Lena, M., Lattuada, A., Milani, F., Monfardini, S., Beretta, G.: Combination chemotherapy and radiotherapy in non-Hodgkin’s lymphomata. Brit. J. Cancer, 31 Suppl. 2 481–488 (1975)Google Scholar
  3. 3.
    Bonnadonna, G., Monfardini. S., De Lena, M., Fossati-Bellani, F., Beretta, G.: Clinical trials with adriamycin. In: International Symposium on Adriamycin, Berlin. Heidelberg. New York: Springer, 1972Google Scholar
  4. 4.
    Brown, T. C., Peters, M. V., Bergsagel, D. E., Reid, J.: A retrospective analysis of the clinical results in relation to the Rappaport histological classification. Br. J. Cancer, 31 Suppl. II, 174–186 (1975)Google Scholar
  5. 5.
    Bryon, P. A., Gentilhomme, O., Fiere, D.: Classification histocytologique des lymphomes malins non hodgkiniens. Nouv. Presse med.5, 514–515 (1976)PubMedGoogle Scholar
  6. 6.
    Byar, D. P.: Analysis of survival data in heterogeneous populations. In: Recent Developments in Statistics, Amsterdam: North Holland, 1977, 51–68Google Scholar
  7. 7.
    Carbone, P. P., Kaplan, H. S., Musshoff, K., Smither, D. W., Tubiana, M.: Report of the committee on Hodgkin’s disease staging classification. Cancer Res.31,1860–1861 (1971)PubMedGoogle Scholar
  8. 8.
    Cimo, P., Rudders, R. A., Hensleigh, D.: A clinical trial of adriamycin in the malignant lymphomas. Cancer,34,1571–1575 (1974)PubMedCrossRefGoogle Scholar
  9. 9.
    Diebold, J.: Proposition pour classer les hématosarcomes lymphoìdes non hodgkiniens. Ann. Anat. Pathol.,20 35–42(1975)Google Scholar
  10. 10.
    Dorfmann, R. F.: Classification of non-Hodgkin’s lymphomas. Lancet, 1,1295–1296 (1974)CrossRefGoogle Scholar
  11. 11.
    Ekert, H., Colebatch, J. H., Matthews, R. N.: Short courses of cytosine arabinoside and L- asparaginase in children with acute leukemia. Cancer, 30, 643–647 (1972)PubMedCrossRefGoogle Scholar
  12. 12.
    Gerard-Marchant, R. I., Hamlin, I., Lennert, K., Rilke, F., Stansfeld, A. G., van Uhnik, J. A. M.: Classification of non-Hodgkin’s lymphomas. Lancet, 2, 406–408 (1974)Google Scholar
  13. 13.
    Goffinet, D. R., Castellino, R. A., Kim, H., Dorfman, R. F., Fuks, Z., Rosenberg, S. A., Nelsen, T., Kaplan, H. S.: Staging laparotomies in unselected previously untreated patients with non- Hodgkin’s lymphomas. Cancer, 32 672–681 (1973)PubMedCrossRefGoogle Scholar
  14. 14.
    Hendin, B., Devivo, D. C, Torack, R., Lell, M. E., Abdelsalam, H. R., Vietti, T. J.: Parenchymatous degeneration of the central nervous system in childhood leukemia. Cancer, 34 468- 482 (1974)CrossRefGoogle Scholar
  15. 15.
    Hustu, H. O., Aur, R. J. A., Verzosa, M. S., Simone, J. V., Pinkel, D.: Prevention of central nervous system leukemia by irradiation. Cancer, 32, 585–597 (1973)PubMedCrossRefGoogle Scholar
  16. 16.
    Jones, S. E., Fuks, Z., Bull, M., Kadin, M. E., Dorfman, R. F., Kaplan, H. S., Rosenberg, S. A., Kim, H.: Non-Hodgkin’s lymphomas. IV. Clinico pathologic correlation in 405 cases. Cancer,31,806- 823 (1973)PubMedCrossRefGoogle Scholar
  17. 17.
    Lennert, K., Mohri, N., Stein, H., Kaiserling, E.: The histopathology of malignant lymphoma. Br. J. Haematol., 31 Suppl., 72, 193–203 (1975)Google Scholar
  18. 18.
    Lukes, R. J., Collins, R. D.: New approaches to the classification of the lymphomata. Br. J. Cancer, 31, Suppl. II, 1–28 (1975)Google Scholar
  19. 19.
    Mathe, G., Belpomme, D., Dantchev, D., Khalil, A., Afifi, A. M., Taleb, N., Pouillart, P., Schwarsenberg, L., Hayat, M., de Vassal, F., Jasmin, C., Misset, J. L., Musset, M.: Immunoblastic lymphosarcomata, a cytological and clinical entity? Biomedicine, 22,473–488 (1975)PubMedGoogle Scholar
  20. 20.
    Mathe, G., Belpomme, D., Dantchev, D., Pouillart, P.: Progress in the classification of lymphoid and/or monocytoid leukemias and of lympho and reticulo sarcomas (Non-Hodgkin’s lymphomas). Biomedicine, 22,177–185 (1975)PubMedGoogle Scholar
  21. 21.
    Mathe, G., Belpomme, D., Dantchev, D., Pouillart, P., Schlumberger, J. R., Lafleur, M.: Leukaemic lymphosarcomas: respective prognosis of the three types: prolymphocyte, lymphoblastic (or lymphoblastoid) and immunoblastic. Blood Cells, 1, 25–36 (1975)Google Scholar
  22. 22.
    Mathe, G., Gerard-Marchant, R., Texier, J. L., Schlumberger, J. R., Berumen, L., Paintrand, M.: The two varieties of lymphoid tissue “reticulosarcomas” histiocytic and histioblastic types. Br. J. Cancer,24, 687–695 (1970)PubMedCrossRefGoogle Scholar
  23. 23.
    McElwain, T. J., Hardisty, R. M.: Remission induction with cytosine arabinoside and L- asparaginase in acute lymphoblastic leukaemia. Br. Med. J.,4, 596–598 (1969)PubMedCrossRefGoogle Scholar
  24. 24.
    Pouillart, P., Ameil, J. L., Mathe, G., Tubiana, M.: Le traitement des lymphorêticulosarcomes de l’adulte (à l’exclusion des formes du carrefour aérodigestif supérieur). Nouv. Presse med., 4, 247–252Google Scholar
  25. 25.
    Rappaport, H.: Tumors of the haematopoietic system. In: Adas of Tumor Pathology, Section 3, Fascicle 8, Ed.: Washington D.C.. Armed Forces Institute of Pathology, 1966Google Scholar
  26. 26.
    Rosengerg, S. A.: Report of the committee on the staging of Hodgkin’s disease. Cancer Res.,26,1310 (1966)Google Scholar
  27. 27.
    Schwartz, D., Flamant, R., Lellouch, J.: L’essai thérapeutique chez l’homme, Paris: Flammarion, 1970Google Scholar
  28. 28.
    Sotto, J. J., Caillot, P., Sotto, M. F., Lachet, B., Martin, H., Bensa, J. C., Hollard, D.: A cytological classification of non-Hodgkin’s malignant lymphomas based on a statistical analysis. (Submitted for publication in Br. J. Cancer)Google Scholar
  29. 29.
    Sotto, J. J., Sotto, M. F., Brambilla, E., Martin, H., Michallet, M., Bensa, J. C., Vrousos, C., Hollard, D.: Non-Hodgkin’s lymphoma (NHL): Multifactorial analysis of prognostic factors; special value of the cytology. 16th Intern. Congr. Hematol., Kyoto, 1976Google Scholar
  30. 30.
    Stein, H., Peterson, N., Gaedicke, G., Lennert, K., Landbeck, G.: Lymphoblastic lymphoma of convoluted or acid phosphatase type—a tumor of T precursor cells. Intern. J. Cancer, 17, 292–295Google Scholar
  31. 31.
    Tubiana M., Le Bourgeois J. P.: La classification et Ie bilan des bematosarcomes. Bull. Cancer, 61, 39–50 (1974)Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1978

Authors and Affiliations

  • J. J. Sotto
  • M. Michallet
  • M. F. Sotto
  • B. Lachet
  • H. Martin
  • R. Schaerer
  • C. Vrousos
  • D. Hollard

There are no affiliations available

Personalised recommendations