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DNA Recombination in Cells Infected with Simian Virus 40

  • D. Nathans
  • M. W. Gutai
Conference paper
Part of the Colloquium der Gesellschaft für Biologische Chemie in Mosbach Baden book series (MOSBACH, volume 28)

Abstract

The genome of Simian Virus 40 (SV40) is a covalently closed circular DNA duplex with about 5200 nucleotide pairs. Based on physiological studies and mapping of temperature-sensitive and deletion mutants, three genes have so far been identified (see Fig. 1). The A gene maps in the early region defined by mRNA mapping, and codes for a protein estimated by gel electrophoresis to be about 90,000 daltons that has “tumor antigen” determinants. The B/C gene maps between 0.94 and 0.17 map units in the late region of the genome and codes for the major structural protein VP1. The D gene maps roughly between map coordinates 0.76 and 0.96, also in the late region, and codes in phase for the overlapping VP2 and VP3 minor virion proteins. (For a recent review of the SV40 genome, see Kelly and Nathans, 1977.)

Keywords

Simian Virus Nucleotide Sequence Level SV40 Genome SV40 Gene SV40 Sequence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • D. Nathans
  • M. W. Gutai

There are no affiliations available

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