DNA Recombination in Cells Infected with Simian Virus 40

  • D. Nathans
  • M. W. Gutai
Conference paper
Part of the Colloquium der Gesellschaft für Biologische Chemie in Mosbach Baden book series (MOSBACH, volume 28)


The genome of Simian Virus 40 (SV40) is a covalently closed circular DNA duplex with about 5200 nucleotide pairs. Based on physiological studies and mapping of temperature-sensitive and deletion mutants, three genes have so far been identified (see Fig. 1). The A gene maps in the early region defined by mRNA mapping, and codes for a protein estimated by gel electrophoresis to be about 90,000 daltons that has “tumor antigen” determinants. The B/C gene maps between 0.94 and 0.17 map units in the late region of the genome and codes for the major structural protein VP1. The D gene maps roughly between map coordinates 0.76 and 0.96, also in the late region, and codes in phase for the overlapping VP2 and VP3 minor virion proteins. (For a recent review of the SV40 genome, see Kelly and Nathans, 1977.)


Simian Virus Nucleotide Sequence Level SV40 Genome SV40 Gene SV40 Sequence 
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© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • D. Nathans
  • M. W. Gutai

There are no affiliations available

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