Abstract
Foldback DNA is DNA that forms duplexes from the single-strand (denatured) state as a result of an intramolecular event. Thus, the rate of its formation is independent of DNA concentration, unlike DNA renaturation. In principle, this can happen in two ways: (1) if a duplex fails to separate during denaturation because of cross-linkage between the complementary strands (other causes, such as firmly bound proteins, would probably be considered to be artifacts), and (2) when a single strand contains complementary sequences in the appropriate orientation. Because of the opposite polarity of the strands of a DNA duplex, this must always lead to the formation of a hairpin structure, with or without a loop.
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Bishop, J.O., Phillips, C. (1978). Is Foldback DNA Repeatedly Transposed?. In: Hofschneider, P.H., Starlinger, P. (eds) Integration and Excision of DNA Molecules. Colloquium der Gesellschaft für Biologische Chemie in Mosbach Baden, vol 28. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81203-3_16
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DOI: https://doi.org/10.1007/978-3-642-81203-3_16
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