Abstract
After infection of either permissive or nonpermissive cells by RNA tumor viruses, viral genetic information appears to persist indefinitely in the form of virus-specific, double-stranded DNA integrated covalently into the host chromosome (Varmus et al., 1975; Weinberg, 1977). In this report, we summarize our progress in deciphering the sequence of molecular events that culminates in the integration of viral DNA into the DNA of avian cells infected by avian sarcoma virus (ASV), and we offer our current view of the mechanisms involved.
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Botchan, M., Topp, W., Sambrook, J.: Cell 9, 269 (1976)
Guntaka, R.V., Many, B., Bishop, J.M., Varmus, H.E.: Nature (London) 253, 507–511 (1975)
Guntaka, R.V., Richards, O.C., Shank, P.R., Kung, H.J., Davidson, N., Fritsch, E., Bishop, J.M., Varmus, H.E.: J. Mol. Biol. 106, 337 (1976)
Haseltine, W.A., Maxam, A.M., Gibbert, W.: Proc. Natl. Acad. Sci. USA 74, 989 (1977)
Ketner, G., Kelly, T.: Proc. Natl. Acad. Sci. USA 73, 1102 (1976)
Ringold, G.R., Cardiff, R.D., Varmus, H.E., Yamamoto, K.R.: Cell 10, 11 (1977)
Ringold, G.R., Yamamoto, K.R., Shank, P.R., Varmus, H.E.: Cell 10, 19 (1977)
Schwartz, D.E., Zamecnik, P.C., Weith, H.L.: Proc. Natl. Acad. Sci. USA 74, 994 (1977)
Shine, J., Czernilofsky, A.P., Friedrich, R., Bishop, J.M., Goodman, H.M.: Proc. Natl. Acad. Sci. USA 74, 1473 (1977)
Taylor, J.M.: Biochim. Biophys. Acta 473, 57 (1977)
Varmus, H.E., Guntaka, R.V., Deng, C.T., Bishop, J.M.: Cold Spring Harbor Symp. Quant. Biol 39, 987 (1975)
Varmus, H.E., Guntaka, R.V., Fan, W., Heasley, S., Bishop, J.M.: Proc. Natl. Acad. Sci. USA 71, 3874 (1974)
Varmus, H.E., Heasley, S., Linn, J., Wheeler, K.: J. Virol. 18, 574 (1976)
Varmus, H.E., Padgett, T., Heasley, S., Simon, G., Bishop, J.M.: Cell, 11, 307 (1977)
Varmus, H.E., Ringold, G.R., Yamamoto, K.R.: In: Glucocorticoid Hormone Action. Baxter, J., Rousseau, G. (eds.). Berlin-Heidelberg-New York: Springer Verlag, 1978, in press
Varmus, H.E., Shank, P.R.: J. Virol, 18, 567 (1976)
Varmus, H.E., Vogt, P.K., Bishop, J.M.: Proc. Natl. Acad. Sci. USA 70, 3067 (1973)
Verma, I.M., Varmus, H.E., Hunter, H.E.: Virology 75, 16 (1976)
Weinberg, R.A.: Biochim. Biophys. Acta 473, 39 (1977)
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Varmus, H.E. et al. (1978). Synthesis and Integration of Virus-specific DNA in Cells Infected by RNA Tumor Viruses. In: Hofschneider, P.H., Starlinger, P. (eds) Integration and Excision of DNA Molecules. Colloquium der Gesellschaft für Biologische Chemie in Mosbach Baden, vol 28. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81203-3_13
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DOI: https://doi.org/10.1007/978-3-642-81203-3_13
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