Abstract
In our preclinical study on 23 rabbits two stimulation methods were compared: stimulation with constant current of amplitude 12 μA and stimulation with monophasic pulsed voltage of amplitude 0.5 V, pulse duration 0.5 s, and frequency 1 Hz. The healing process was examined in a standardized bone defect — a drilled hole of 4 mm diameter — in the right rabbit tibia. The contralateral tibia was used as a reference. The stimulator was implanted in the dorsum of the rabbit and the electrodes were subcutaneously drawn to the active right tibia and fixed in small drilled holes proximally and distally to the bone defect — the anode 12 mm and the cathode 1 mm from it, not in it, since we wanted to avoid artifacts by trauma (Fig.1). A 3-mm long platinum tip connected to a Teflon-coated multistrand stainless steel wire served as anode, and the uncoated 3-mm end of such a wire served as cathode. The results were analyzed macroscopically, radiologically, and histologically.
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von Satzger, G., Herbst, E. (1978). Electric Stimulation of Osteogenesis: I. Experimental Study of Bone Healing in the Rabbit Tibia II. Clinical Study in Two Cases of Congenital Pseudarthrosis of the Tibia. In: Burny, F., Herbst, E., Hinsenkamp, M. (eds) Electric Stimulation of Bone Growth and Repair. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81193-7_10
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DOI: https://doi.org/10.1007/978-3-642-81193-7_10
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