Abstract
Many essential functions of biological membrane systems (e.g. nerve and muscle membranes) are coupled to their permeabilities to cations. The cation permeabilities of biological membranes are controlled by specific permeation proteins which often confer a remarkable alkali ion specificity to the membrane in which they are situated (Fig. 1a). It is important to note here that the maximum permeability is not obtained with the smallest or the largest alkali ion. In Figure 1c a similar specificity of the enzymic activity of pyruvate carboxylase for alkali ions is shown.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
AHRENS, M.-L.: Proton transfer kinetics of 51-deoxypyridoxal. Biochim. Biophys. Acta 320, 86–96 (1973)
BAMBERG, E., BENZ, R., LAEUGER, P., STARK, G.: Ionentransport durch biologische Membranen. Chiuz 8, 33–43 (1974)
BURGERMEISTER, W., WIELAND, Th., WINKLER, R.: Antamanide. Dynamics of metal-complex formation. Eur. J. Biochem. 44, 305–310 (1974)
CHOCK, P.B.: Relaxation study of complex formation between monovalent cations and cyclic polyethers. Proc. Nat. Acad. Sci. (Wash.) 69, 1939–1942 (1972)
DIEBLER, H., EIGEN, M., ILGENFRITZ, G., MAAß, G., WINKLER, R.: Kinetics and mechanism of reactions of main group metal ions with biological carriers. Pure Appl. Chem. 20, 93–115 (1969)
DIETRICH, B., LEHN, J.-M., SAUVAGE, J.-P.: Kryptate: makrocycli- sche Metallkomplexe. Chiuz 7, 120–128 (1973)
EIGEN, M., DE MAEYER, L.: Theoretical basis of relaxation spectrometry. In: Techniques of Chemistry. WEISSBERGER, A. (ed.); Vol. VI, Part 2; HAMMES, G.G. (ed.); pp. 63–146. New York: Wiley 1973
EIGEN, M., WINKLER, R.: Alkali-ion carriers: dynamics and selectivity. In: The Neurosciences, Second Study Program. SCHMITT, F.O. (ed.); pp 685–695. New York: Rockefeller Univ. Press 1970
FUNCK, Th., EGGERS, F., GRELL, E.: Kinetik und Mechanismus der selektiven Bindung von Ionen durch Dyclodepsipeptid-Antibiotika. Chimia 26, 637–641 (1972)
GRELL, E., EGGERS, F., FUNCK, Th.: Konformationsanalyse und Kinetik der Konformationsänderungen von membranaktiven Antibiotika. Chimia 26, 632–637 (1972a)
GRELL, E., FUNCK, Th.: Dynamic properties and membrane activity of ion specific antibiotics. J. Supramol. Structure 307–335 (1973)
GRELL, E., FUNCK, Th., EGGERS, F.: Dynamic properties and membrane activity of ion specific antibiotics. In: Molecular Mechanism of Antibiotic Action on Protein Biosynthesis and Membranes. MUNOZ, E., GARCIA-FERRANDIZ, F., VASQUEZ, D. (eds.); pp. 645–685. Amsterdam: Elseyier 1972b
GRELL, E., FUNCK, Th., EGGERS, F.: Structure and dynamic properties of ion-specific antibiotics. In: Membranes. EISENMAN, G. (ed.); Vol. III, pp. 1–126. New York: Dekker 1975
GRELL, E., FUNCK, Th., SAUTER, H.P.: Carbon-13 nuclear-magnetic- resonance and infrared-absorption spectroscopy of valinomycin and its alkali-ion complexes. Europ. J. Biochem. 34, 415–424 (1973)
GRELL, E., OBERBAEUMER, I., RUF, H., ZINGSHEIM, H.P.: Elementary steps and dynamic aspects of carrier-mediated cation transport through membranes: the streptogramin antibiotics (group B). In: Biochemistry of Membrane Transport. SEMENZA, G., CARAFOLI, E. (eds.); pp. 147–178. Berlin-Heidelberg-New York: Springer 1977
HAGIWARA, S., EATON, D.C., STUART, A.E., ROSENTHAL, N.P.: Cation selectivity of the resting membrane of squid axon. J. Membrane Biol. 1, 373–384 (1972)
HAGIWARA, S., TOYAMA, K., HAYASHI, H.: Mechanisms of anion and cation permeations in the resting membrane of a barnacle muscle fiber. J. Gen. Physiol. 57, 408–434 (1971)
HILLE, B.I Size of the selectivity filter in the K channel of frog nerve. Biophys. J. 12, 123a (1972)
ISMAILOV, N.A.: Energy of solvation of individual ions in non-aqueous solutions (russian), Dokl. Akad. Nauk S.S.S.R. 149, 1364–1367 (1963)
IVANOV, V.T., LAINE, I.A., ABDULAEV, N.D., SENYAVINA, L.B., POPOV, E.M., OVCHINNIKOV, Yu.A., SHEMYAKIN, M.M.: The physicochemical basis of the functioning of biological membranes: the 5 conformation of valinomycin and its K+ complex in solution. Biochem. Biophys. Res. Commun. 34, 803–811 (1969)
LEHN, J.M., SAUVAGE, J.P.: Cation and cavity selectivities of alkali and alkaline-earth “cryptâtes”. Chem. Commun. 440–441 (1971)
MAYERS, D.F., URRY, D.W.: Valinomycin-cation complex. Conformational energy aspects. J. Am. Chem. Soc. 94, 77–81 (1972)
McCLURE, W.R., LARDY, H.A., KNEIFEL, H.: Rat liver pyruvate carboxylase: I. Preparation, properties and cation specificity. J. Biol. Chem. 246, 3569–3578 (1971)
MUELLER, P., RUDIN, D.O.: Development of K+ - Na+ discrimination in experimental bimolecular lipid membranes by macrocyclic antibiotics. Biochem. Biophys. Res. Commun. 26, 398–404 (1967)
OBERBAEUMER, I.: Versuche zur Charakterisierung der Wechselwirkungen des Antibiotikums Virginiamycin S mit Lipid-Membranen. Diplomarbeit Göttingen, 1975
OVCHINNIKOV, Yu.A., IVANOV, V.T., SHKROB, A.M.: Membrane-active complexones. B.B.A. Library, Vol. 12. Amsterdam: Elsevier 1974
PEDERSEN, C.J.: Cyclic polyethers and their complexes with metal salts. J. Am. Chem. Soc. 89, 7017–7036 (1967)
PINKERTON, M., STEINRAUF, L.K., DAWKINS, P.: The molecular structure and some transport properties of valinomycin. Biochem. Biophys. Res. Commun. 35, 512–518 (1969)
SCHUSTER, P., TORTSCHANOFF, K., WINKLER, H.: Protoneniibertraguns- reaktionen zweibasischer Säuren in wässriger Lösung: 3-Hydroxy- pyridin. Z. Naturforsch. 31C, 219–224 (1976)
SCHUSTER, P., WOLSCHANN, K.P., TORTSCHANOFF, K.: Dynamics of proton transfer. This volume, pp. 107–190. Berlin-Heidelberg- New York: Springer 1977
SHEMYAKIN, M.M., OVCHINNIKOV, Yu.A., IVANOV, V.T., ANTONOV, V.K., VINOGRADOVA, E.I., SHKROB, A.M., MALENKOV, G.G., EVSTRATOV, A.V., LAINE, I.A., MELNIK, E.I., RYABOVA, I.D.: Cyclodepsipep- tides as chemical tools for studying ionic transport through membranes. J. Membrane Biol.1, 402–430 (1969)
STARK, G., KETTERER, B., BENZ, R., LAEUGER, P.: The rate constants of valinomycin-mediated ion transport through thin lipid membranes. Biophys. J. 11, 981–994 (1971)
SZABO, G., EISENMAN, G., LAPRADE, R., CIANI, S.M., KRASNE, S.: Experimentally observed effects of carriers on the electrical properties of bilayer membranes-equilibiium domain. In: Membranes. EISENMAN, G. (ed.); Vol. II, pp. 179–328. New York: Dekker 1973
VANDERHAEGHE, H., PARMENTIER, G.: The structure of factor S of staphylomycin. J. Am. Chem. Soc. 82, 4414–4422 (1960)
WINKLER, R.: Kinetics and mechanism of alkali ion complex formation in solution.: In Structure and Bonding, Vol. X, pp. 1–24. Berlin-Heidelberg-New York: Springer 1972
ZUEST, Ch.U., FRUEH, P.U., SIMON, W.: Complex formation of macrotetrolide carrier antibiotics with cations studied by microcalor imetry and vapour pressure osmometry. Helv. Chim. Acta 56, 495–499 (1973)
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1977 Springer-Verlag Berlin. Heidelberg
About this chapter
Cite this chapter
Grell, E., Oberbäumer, I. (1977). Dynamic Aspects of Carrier-Mediated Cation Transport Through Membranes. In: Pecht, I., Rigler, R. (eds) Chemical Relaxation in Molecular Biology. Molecular Biology Biochemistry and Biophysics, vol 24. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81117-3_11
Download citation
DOI: https://doi.org/10.1007/978-3-642-81117-3_11
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-81119-7
Online ISBN: 978-3-642-81117-3
eBook Packages: Springer Book Archive