Expression of Secondary Metabolism An Aspect of Cell Specialization of Microorganisms, Higher Plants, and Animals

Part of the Molecular Biology, Biochemistry and Biophysics book series (MOLECULAR, volume 23)


In addition to the primary metabolic reactions, which are similar in all living beings (formation and breakdown of nucleic acids and proteins as well as of their precursors, of most carbohydrates, of some carboxylic acids, etc.), a vast number of metabolic pathways lead to the formation of compounds peculiar to a few species or even to a single chemical race only. These reactions, in accord with CZAPEK (1921) and PAECH (1950), are summed up under the term “secondary metabolism”, and their products are called “secondary metabolites.”


Secondary Metabolism Cinnamic Acid Phenol Oxidase Alkaloid Biosynthesis Cinnamic Acid Derivative 
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  1. ABOUTABL, S.A. EL, EL AZZOUNY, A., WINTER, K., LUCKNER, M.: Stereochemical aspects of the conversion of cyclopeptine into dehydrocyclopeptine by cyclopeptine dehydrogenase from Pénicillium cyclopium. Phytochemistry 15, 1925–1928 (1976).Google Scholar
  2. ABOUTABL, S.A. EL, LUCKNER, M.: Cyclopeptine dehydrogenase in Pénicillium cyclopium. Phytochemistry 14, 2573–2577 (1975).Google Scholar
  3. ACTON, G.J., SCHOPFER, P.: Control over activation or synthesis of phenylalanine ammonia-lyase by phytochrome in mustard (Sina- pis alba L.). Biochim. Biophys. Acta 404, 231–242 (1975).PubMedGoogle Scholar
  4. ALFERMANN, W., REINHARD, E.: Isolierung anthocyanhaltiger und anthocyanfreier Gewebestämme von Daucus carota: Einfluß von Auxin auf die Anthocyanbilding. Experientia 27., 353–354 (1971).Google Scholar
  5. ALFERMANN, W., REINHARD, E.: Influence of phytohormones on secondary product formation in plant cell cultures. In: Secondary Metabolism and Coevolution. LUCKNER, M., MOTHES, K., NOVER, L. (eds.). Nova Acta Leopoldina, Suppl. 7, 345–356 (1976).Google Scholar
  6. AMRHEIN, N.: Evidence against the occurrence of adenosine-3 1, 51 -cyclic monophosphate in higher plants. Planta (Berlin) 118, 241–258 (1974).Google Scholar
  7. AMRHEIN, N., ZENK, M.H.: Concomitant induction of phenylalanine ammonia-lyase and cinnamic acid 4-hydroxylase during illumination of excised buckwheat hypocotyls. Naturwissenschaften 57, 312 (1970).Google Scholar
  8. ASHIDA, M., OHNISHI, E.: Activation of pre-phenol oxidase in hemolymph of the silkworm, Bombyx mori. Arch. Biochem. Biophys. 122, 411–416 (1967).PubMedGoogle Scholar
  9. ASHWORTH, J.M.: Cell development in the cellular slime mould Dictyostelium discoideum. Symp. Soc. Exp. Biol. 25, 27–49 (1971).PubMedGoogle Scholar
  10. ATTRIDGE, T.H., FRENCH, C.J., SMITH, H.: The photocontrol of phenylalanine ammonia-lyase levels in Gherkin seedlings - Activation or de novo synthesis? In: Mechanisms of Regulation of Plant Growth. BIELSKI, R.L., FERGUSON, A.F., CRESSWELL, M.M. (eds.). Royal Society of New Zealand: Wellington 1974a, Bull. 12, pp. 361–364.Google Scholar
  11. ATTRIDGE, T.H., JOHNSON, C.B., SMITH, H.: Density-labelling evidence for the phytochrome-mediated activation of phenylalanine ammonia-lyase in mustard cotyledons. Biochim. Biophys. Acta 343, 440–451 (1974b).PubMedGoogle Scholar
  12. ATTRIDGE, T.H., SMITH, H.: Evidence for a pool of inactive phenylalanine ammonia-lyase in Cucumis sativus seedlings. Phytochemistry 12, 1569–1574 (1973).Google Scholar
  13. BAUTZ, E.K.F.: Regulation of RNA synthesis. Progr. Nucl. Acid Res. Molec. Biol. 12, 129–160 (1972).Google Scholar
  14. BECKWITH, J., ROSSOW, P.: Analysis of genetic regulatory mechanisms. Ann. Rev. Genetics 8, 1–13 (1974).Google Scholar
  15. BEERMANN, W. (ed.): Developmental studies on giant chromosomes. Res. Probl. Cell Diff. Berlin-Heidelberg-New York: Springer 1972, Vol. 4.Google Scholar
  16. BELL, E.: Informational DNA synthesis distinguished from that of nuclear DNA by inhibitors of DNA synthesis. Science 174, 603–606 (1971).PubMedGoogle Scholar
  17. BELLINI, E., MARTINELLI, M.: Anthocyanin synthesis in radish seedlings: Effects of continuous far red irradiation and phytochrome transformations. Z. Pflanzenphysiol. 70, 12–21 (1973).Google Scholar
  18. BERTRAND, K., KORN, L., LEE, F., PLATT, T., SQUIRES, C.L., SQUIRES, C., YANOFSKY, C.: New features of the regulation of the try operon. Science 189, 22–26 (1975).PubMedGoogle Scholar
  19. BETZ, J., TRÄGER, L.: Enzyminduktion bei Streptomyces hydrogenans Qualitative and quantitative Änderungen des RNA-gehaltes und der RNA-synthese während der Induktion. Z. physiol. Chem. 356, 357–366 (1975).Google Scholar
  20. BÖHM, H.: Über Papaver bracteatum Lindl., 8. Mitt.: Erneutes Auftreten von Alpinigenin in Thebain-Typen nach Verfütterung von Tetrahydropalmatin. Biochem. Physiol. Pflanz. 162, 4 74–477 (1971).Google Scholar
  21. BOIME, I., BOGUSLAWSKI, S., CAINE, J.: The translation of a human placental lactogen mRNA fraction in heterologous cell-free systems: The synthesis of a possible precursor. Biochem. Bio- phys. Res. Commun. 62, 103–109 (1975).Google Scholar
  22. BONNER, J.T.: Aggregation and differentiation in the cellular slime moulds. Ann. Rev. Microbiol. 25., 75–92 (1971).Google Scholar
  23. BOULTER, D., ELLIS, R.J., YARWOOD, A.: Biochemistry of protein synthesis in plants. Biol. Rev. 47, 113–175 (1972).Google Scholar
  24. BOYD, G.S., BROWNIE, A.C., JEFCOATE, C.R., SIMPSON, E.R.: Cho- lesterole hydroxylation in the adrenal cortex and liver. Biochem. J. 125, 1P-2P (1971).PubMedGoogle Scholar
  25. BRAWERMAN, G.: Eukaryotic messenger RNA. Ann. Rev. Biochem. 43, 621–642 (1974).PubMedGoogle Scholar
  26. BREINDL, M., HOLLAND, J.J.: Coupled in vitro transcription and translation of vesicular stomatitis virus messenger RNA. Proc. Nat. Acad. Sci. 72, 2545–2549 (1975).PubMedGoogle Scholar
  27. BRIARTY, L.G., COULT, D.A., BOULTER, D.: Protein bodies of developing seeds of Vicea faba. J. Exp. Botany 20, 358–372 (1969)Google Scholar
  28. BRIGGS, W.R., RICE, H.V.: Phytochrome, chemical and physical properties and mechanism of action. Ann. Rev. Plant Physiol. - 23, 293–334 (1972).Google Scholar
  29. BROOKS, J., GRANT, P.R., MUIR, M., GIJZEL, P. VAN, SHAW, G. (eds.):Sporopollenin. London: Academic Press 1971.Google Scholar
  30. BU’LOCK, J.D., BARR, J.G.: A regulation mechanism linking tryptophan uptake and synthesis with ergot alkaloid synthesis in Claviceps. Lloydia 31, 342–354 (1968).Google Scholar
  31. BU’LOCK, J.D., DRAKE, D., WINSTANLEY, D.J.: Specificity and transformations of the trisporic acid series of fungal sex hormones. Phytochemistry 11, 2011–2018 (1972).Google Scholar
  32. BU’LOCK, J.D., HAMILTON, D., HULME, M.A., POWELL, A.J., SMALLEY, H.M., SHEPHERD, D., SMITH, G.N.: Metabolic development and secondary biosynthesis in Pénicillium urticae. Can. J. Microbiol. 11/ 765–778 (1965).PubMedGoogle Scholar
  33. BU’LOCK, J.D., SHEPHERD, D., WINSTANLEY, D.J.: Regulation of 6-methyl salicylate and patulin synthesis in Pénicillium urticae. Can. J. Microbiol. 15, 279–282 (1969).PubMedGoogle Scholar
  34. BURG, S.P.: Ethylene in plant growth. Proc. Nat. Acad. Sci. 70., 591–597 (1973).PubMedGoogle Scholar
  35. BURGEFF, H.: Untersuchungen über Sexualität und Parasitismus bei Mucorineen I. Botan. Abhandl. 4, 1–135 (1924).Google Scholar
  36. BURNETT, A.L.: The acquisition, maintenance, and lability of the differentiated state in Hydra. In: The Stability of the Differentiated State. URSPRUNG, H. (ed.). Berlin-Heidelberg- New York: Springer 1968, Vol. 1, pp. 109–127.Google Scholar
  37. CALHOUN, D.H., HATFIELD, G.W.: Autoregulation of gene expression. Ann. Rev. Microbiol. 29, 275–299 (1975).Google Scholar
  38. CAMM, E.L., TOWERS, G.H.N.: Phenylalanine ammonia-lyase. Phyto- chemistry 12., 961–973 (1973).Google Scholar
  39. CARSIOTIS, M., JONES, R.F., LACY, A.M., CLEARY, T.J., FRANKHAU- SER, D.B.: Histidine-mediated control of tryptophan biosyn- thetic enzymes in Neurospora crassa. J. Bacterid. 104, 98–106 (1970).Google Scholar
  40. CASHEL, M.: Regulation of bacterial ppGpp and pppGpp. Ann. Rev. Microbiol. 29, 301–318 (1975).Google Scholar
  41. CLEVER, U.: The effect of ecdysone on gene activity patterns in giant chromosomes. In: Mechanisms of Hormone Action. KARLSON, P. (ed.). Stuttgart: Thieme and New York: Academic Press 1965, pp. 142–148.Google Scholar
  42. CLEVER, U., KARLSON, P.: Induktion von Puff-Veränderungen in den Speicheldrüsenchromosomen von Chironomus tentans durch Ecdyson. Exp. Cell Res. 20, 623–626 (1960).PubMedGoogle Scholar
  43. CLUTTERBUCK, A.J.: The effect of morphological and spore colour mutants on a spore specific enzyme of Aspergillus nidulans. Genetics 24, 515 (1969).Google Scholar
  44. COHEN, M.E., HAMILTON, T.H.: Effect of estradiol-173 on the synthesis of specific uterine nonhistone chromosomal proteins. Proc. Nat. Acad. Sci. 72, 4346–4350 (1975).PubMedGoogle Scholar
  45. COHEN, P.P., BROWN, G.W.: Ammonia metabolism and urea biosynthesis. Comparat. Biochem. 2, 161–214 (1960).Google Scholar
  46. COLOMAS, J., BULARD, C.: Irradiations à faible énergie et bio- synthêse d’amarantine chez des plantules d’Amaranthus tricolor L. var. tricolor ruber Hort. Planta (Berlin) 124, 245–254 (1975).Google Scholar
  47. CONSTABEL, F., SHYLUK, J.P., GAMBORG, O.L.: The effect of hormones on anthocyanin accumulation in cell cultures of Haplo- pappus gracilis. Planta (Berlin) 96, 306–316 (1971).Google Scholar
  48. COOKE, R.J., SAUNDERS, P.F.: Phytochrome-mediated changes in extractable gibberellin activity in a cell-free system from etiolated wheat leaves. Planta (Berlin) 123, 299–302 (1975).Google Scholar
  49. COOKE, R.J., SAUNDERS, P.F., KENDRICK, R.E.: Red light induced production of gibberellin-like substances in homogenates of etiolated wheat leaves and in suspensions of intact etioplasts. Planta (Berlin) 124, 319–328 (1975).Google Scholar
  50. COOTE, J.G., MANDELSTAM, J.: Use of constracted double mutants for determining the temporal order of expression of sporulation genes in Bacillus subtilis. J. Bacteriol. 114, 1254–1263 (1973).PubMedGoogle Scholar
  51. CORRIGAN, J.J.: Nitrogen metabolism in insects. In: Comparative Biochemistry of Nitrogen Metabolism. CAMPBELL, J.W. (ed.). London-New York: Academic Press 1970, Vol. 1, pp. 387–488.Google Scholar
  52. COVE, D.J., PATEMAN, J.A.: Autoregulation of the synthesis of nitrate reductase in Aspergillus nidulans. J. Bacteriol. 97, 1374–1378 (1969).PubMedGoogle Scholar
  53. CRAKER, L.E.: Effect of ethylene and metabolic inhibitors on anthocyanin biosynthesis. Phytochemistry 14, 151–153 (1975).Google Scholar
  54. CRAKER, L.E., ABELES, F.B., SHROPSHIRE, W.: Light-induced ethylene production in Sorghum. Plant Physiol. 51, 1082–1083 (1973).PubMedGoogle Scholar
  55. CRAKER, L.E., WETHERBEE, P.J.: Ethylene, carbon dioxide, and anthocyanin synthesis. Plant Physiol. 52, 177–179 (1973).PubMedGoogle Scholar
  56. CREASY, L.L., ZUCKER, M.: Phenylalanine ammonia-lyase and phenolic metabolism. In: Metabolism and Regulation of Secondary Plant Products. RUNECKLES, V.C., CONN, E.E. (eds.). Ree. Advan Phytochemistry 8, 1–19 (1974).Google Scholar
  57. CYBIS, J., WEGLENSKI, P.: Arginase induction in Aspergillus nidulans. The appearance and decay of the coding capacity of messenger. Europ. J. Biochem. 30, 262–268 (1972).PubMedGoogle Scholar
  58. CZAPEK, F.: Biochemie der Pflanzen. Jena: Fischer 1921, Vol. III, p. 220.Google Scholar
  59. CZICHI, U., KINDL, H.: A model of closely assembled consecutive enzymes on membranes: Formation of hydroxycinnamic acids from L-phenylalanine on thylakoids of Dunaliella marina. Hoppe- Seyler1 s Z. physiol. Chem. 356, 475–485 (1975).Google Scholar
  60. DARMON, M., BRÄCHET, P., PEREIRA DA SILVA, L.H.: Chemotactic signals induce cell differentiation in Dictyostelium discoi- deum. Proc. Nat. Acad. Sci. 72, 3163–3166 (1975).PubMedGoogle Scholar
  61. DAVIS, W.W., GARREN, L.D.: On the mechanism of action of adreno- corticotrophic hormone. The inhibitory site of cycloheximide in the pathway of steroid biosynthesis. J. Biol. Chem. 243, 5153–5157 (1968).PubMedGoogle Scholar
  62. DEMAIN, A.L.: Regulatory mechanisms and the industrial production of microbial metabolites. Lloydia 31, 395–418 (1968).Google Scholar
  63. DEMAIN, A.L.: Overproduction of microbial metabolites and enzymes due to alteration of regulation. Advan. Biochem. Engineering 113–142 (1971).Google Scholar
  64. DEMAIN, A.L.: Cellular and environment factors affecting the synthesis and excretion of metabolites. J. appl. Chem. Bio- technol. 22, 345–362 (1972).Google Scholar
  65. DEMPSEY, M.E.: Regulation of steroid biosynthesis. Ann. Rev. Biochem. 43, 967–990 (1974).PubMedGoogle Scholar
  66. DI CIOCCIO, R.A., STRAUSS, N.: Patterns of transcription in Bacillus subtilis during sporulation. J. Mol. Biol. 77, 325- 336 (1973).Google Scholar
  67. DICKSON, R.C., ABELSON, J., BARNES, W.M., REZNIKOFF, W.S.: Genetic regulation: the lac control region. Science 187, 27–35 (1975).PubMedGoogle Scholar
  68. DIENSTMAN, S.R., HOLTZER, H.: Myogenesis: a cell lineage interpretation. In: Cell Cycle and Cell Differentiation. BEERMANN, W., HOLTZER, H., REINERT, J., URSPRUNG, H. (eds.). Berlin- Heidelberg-New York: Springer 1975, pp. 1–25.Google Scholar
  69. DRUMM, H., WILDERMANN, A., MOHR, H.: The “high-irradiance response” in anthocyanin formation as related to the phytochrom level. Photochem. Photobiol. 21, 269–273 (1975).PubMedGoogle Scholar
  70. DRUMMOND, G.J., GREENGARD, P., ROBISON, G.A. (eds.): Advances in Cyclic Nucleotide Research. New York: Raven Press 1975.Google Scholar
  71. DUFFY, J.J., PETRUSEK, R.L., GEIDUSCHEK, E.P.: Conversion of Bacillus subtilis RNA polymerase activity in vitro by a protein induced by phage SP01. Proc. Nat. Acad. Sci. 12, 2366–2370 (1975).Google Scholar
  72. DUNKEL, R., MÜLLER, W., NOVER, L., LUCKNER, M.: Stimulation of alkaloid formation in Pénicillium cyclopium WESTLING by phenyl.alanine and mycelial extracts. In: Secondary Metabolism and Coevolution. LUCKNER, M., MOTHES, K., NOVER, L. (eds.). Nova Acta Leopoldina, Suppl. 7, 281–288 (1976).Google Scholar
  73. EBEL, J., SCHALLER-HEKELER, B., KNOBLOCH, K.-H., WELLMANN, E., GRISEBACH, H., HAHLBROCK, K.: Coordinated changes in enzyme activities of phenylpropanoid metabolism during the growthof soybean cell suspension cultures. Biochim. Biophys. Acta 362, 417–424 (1974).PubMedGoogle Scholar
  74. ELGIN, S.C.R., WEINTRAUB, H.: Chromosomal proteins and chromatin structure. Ann. Rev. Biochem. 725–774 (1975).Google Scholar
  75. EL KOUSY, S., PFEIFFER, E., ININGER, G., ROOS, W., NOVER, L., LUCKNER, M.: Influence of inhibitors of gene expression on processes of cell specialization during the idiophase development of Pénicillium cyclopium WESTLING. Biochem. Physiol. Pflanz. 168, 79–85 (1975).Google Scholar
  76. ENGELSBERG, E., WILCOX, G.: Regulation: Positive control. Ann. Rev. Genetics 8, 219–242 (1974).Google Scholar
  77. ENGELSMA, G.: Photoinduction of phenylalanine deaminase in gherkin seedlings. III. Effects of excision and irradiation on enzyme development in hypocotyl segments. Planta (Berlin) 82, 355–368 (1968).Google Scholar
  78. ENGELSMA, G.: On the mechanism of the changes in phenylalanine ammonia-lyase activity induced by ultraviolet and blue light in Gherkin hypocotyls. Plant Physiol. 54, 702–705 (1974).PubMedGoogle Scholar
  79. ERGE, D., MAIER, W., GRÖGER, D.: Untersuchungen über die enzy- matische Umwandlung von Chanoclavin-I. Biochem. Physiol. Pflanz. 164, 234–247 (1973).Google Scholar
  80. FAILLA, D., TOMKINS, G.M., SANTI, D.V.: Partial purification of a glucocorticoid receptor. Proc. Nat. Acad. Sci. 12, 3849–3852 (1975).Google Scholar
  81. FALK, M., WOLLMANN, R.: Differenzierungsprozesse und Entwicklungsphasen bei Pénicillium cyclopium WESTLING - Morphologisch- cytologische Untersuchungen. Pharmazie 29, 77 (1974).Google Scholar
  82. FAN, H., PENMAN, S.: Regulation of protein synthesis in mammalian cells. 2. Inhibition of protein synthesis at the level of initiation during mitosis. J. Mol. Biol. 50, 655–670 (1970).PubMedGoogle Scholar
  83. FEOFILOVA, E.P., BEKHTEREVA, M.N.: Effect of vitamin A on biosynthesis of carotene by Blakeslea trispora. Mikrobiologija 45, 557–558 (1976).Google Scholar
  84. FILNER, P.: Control of nutrient assimilation, a growth-regulating mechanism in cultured plant cells. Develop. Biology, Suppl. 3, 206–226 (1969).Google Scholar
  85. FILNER, P., WRAY, J.L., VARNER, J.E.: Enzyme induction in higher plants. Science 165, 358–367 (1969).PubMedGoogle Scholar
  86. FLOSS, H.G., MOTHES, U.: Über den Einfluß von Tryptophan und analogen Verbindungen auf die Biosynthese von Clavinalkaloiden in saprophytischer Kultur. Arch. Mikrobiol. 48., 213–221 (1964).PubMedGoogle Scholar
  87. FLOSS, H.G., ROBBERS, J.E., HEINSTEIN, P.F.: Regulatory control mechanisms in alkaloid biosynthesis. In: Metabolism and Regulation of Secondary Plant Products. RUNECKLES, V.C., CONN, E.E. (eds.). New York: Academic Press, Recent Advan. Phytochem. 8, 141–175 (1974).Google Scholar
  88. FOARD, D.E.: Differentiation in plant cells. In: Cell Differentiation. SCHJEIDE, O.A., DE VELLIS, J. (eds.). New York: van Nostrand Reinhold Comp. 1970, pp. 575–602.Google Scholar
  89. FOOR, F., JANSSEN, K.A., MAGASANIK, B.: Regulation of synthesis of glutamine synthetase by adenylated glutamine synthetase. Proc. Nat. Acad. Sci. 72, 4844–4848 (1975).PubMedGoogle Scholar
  90. FORGET, B.G., HOUSMAN, D., BENZ, E.J., McCAFFREY, R.P.: Synthesis of DNA complementary to separated human alpha and beta globin messenger RNAs. Proc. Nat. Acad. Sci. 72, 984–988 (1975).PubMedGoogle Scholar
  91. FORRESTER, P.I., GAUCHER, G.M.: m-Hydroxybenzyl alcohol dehydrogenase from Pénicillium urticae. Biochemistry 11, 1108–1114 (1972).PubMedGoogle Scholar
  92. FOURNIER, M.J., BRENNER, D.J., DOCTOR, B.P.: The isolation of genes: a review of advances in the enrichment, isolation, and in vitro synthesis of specific cistrons. Progr. Molec. Subcell Biol. 3, 15–84 (1973).Google Scholar
  93. FRAGOULIS, E.G., SEKERIS, C.E.: Induction of dopa (3, 4-dihydro- xyphenylalanine) decarboxylase in blowfly integument by ecdy- sone. A demonstration of synthesis of the enzyme de novo. Biochem. J. U6, 121–126 (1975a).Google Scholar
  94. FRAGOULIS, E.G., SEKERIS, C.E.: Translation of m-RNA for 3, 4- dihydroxyphenylalanine decarboxylase isolated from Epidermis tissue of Calliphora vicina R.-D. in an heterologous system. Dependence of m-RNA concentration on the insect steroid hormone ecdysone. Eur op. J. Biochem. 51, 305–316 (1975b).Google Scholar
  95. FRAMM, J., NOVER, L., EL AZZOUNY, A., RICHTER, H., WINTER, K., WERNER, S., LUCKNER, M.: Cyclopeptin und Dehydrocyclopeptin, Zwischenprodukte der Biosynthese von Alkaloiden der Cyclopenin Viridicatin-Gruppe bei Pénicillium cyclopium WESTLING. Europ. J. Biochem. 37, 78–85 (1973).PubMedGoogle Scholar
  96. FRENCH, C.J., SMITH, H.: An inactivator of phenylalanine ammonia lyase from gherkin hypocotyls. Phyto chemistry 14, 963–966 (1975).Google Scholar
  97. FREY-WYSSLING, A.: Die Stoffaus Scheidung der höheren Pflanzen. Berlin: Springer 1935, p. 378.Google Scholar
  98. FREY-WYSSLING, A.: Betrachtungen über pflanzliche Stoffelimination. Ber. Schweiz. Botan. Ges. 80, 454–466 (1970).Google Scholar
  99. FRIEDEN, E., JUST, J.J.: Hormonal responses in amphibian metamorphosis. In: Biochemical Actions of Hormones. LITWACK, G. (ed.). New York: Academic Press 1970, pp. 1–52.Google Scholar
  100. GALSKY, A.G., LIPPINCOTT, J.A.: Promotion and inhibition of a- amylase production in barley endosperm by cyclic AMP and ADP. Plant Cell Physiol. 10, 607–620 (1969).Google Scholar
  101. GILBERT, W., MAXAM, A.: The nucleotide sequence of the lac operator. Proc. Nat. Acad. Sci. 70, 3581–3584 (1973).PubMedGoogle Scholar
  102. GILL, R., VINCE, D.: Photocontrol of anthocyanin formation in turnip seedlings. Planta (Berlin) 86, 116–123 (1969).Google Scholar
  103. GIUDICI DE NICOLA, M., AMICO, V., SCIUTO, S., PIATTELLI, M.: Light control of amaranthin synthesis in isolated Amaranthus cotyledons. Phytochemistry 14, 479–481 (1975).Google Scholar
  104. GIUDICI DE NICOLA, M., PIATTELLI, M., AMICO, V.: Photocontrol of betaxanthin synthesis in Celosia plumosa seedlings. Phytochemistry 12, 353–357 (1973).Google Scholar
  105. GODCHAUX, W., ADAMSON, S.D., HERBERT, E.: Effects of cyclohexi- mide on polyribosome function in reticulocytes. J. Mol. Biol. 27, 57–72 (1967).PubMedGoogle Scholar
  106. GOLDBERGER, R.F.: Autogenous regulation of gene expression. Science 183, 810–816 (1974).PubMedGoogle Scholar
  107. GOODAY, G.W.: Fungal sex hormones. Ann. Rev. Biochem. 43, 35–49 (1974).PubMedGoogle Scholar
  108. GRANICK, S.: The heme and chlorophyll biosynthetic chain. In: Biochemistry of Chloroplasts. GOODWIN, T.W. (ed.). New York: Academic Press 1967, Vol. II, pp. 373–410.Google Scholar
  109. GREENGARD, O.: Enzymic differentiation in mammalian tissues. Essays in Biochemistry 159–205 (1971).Google Scholar
  110. GREENLEAF, A.L., LINN, T.G., LOSICK, R.: Isolation of a new RNA polymerase-binding protein from sporulating Bacillus subtilis. Proc. Nat. Acad. Sci. 70, 490–494 (1973).PubMedGoogle Scholar
  111. GRISEBACH, H.: Neuere Untersuchungen zur Biosynthese einiger Antibiotica. Planta Med. (Stutt.) Supp. 232–250 (1975).Google Scholar
  112. GRISEBACH, H., HAHLBROCK, K.: Enzymology and regulation of flavonoid and lignin biosynthesis in plants and plant cell cultures. In: Metabolism and Regulation of Secondary Plant Products. RUNECKLES, V.C., CONN, E.E. (eds.). New York: Academic Press 1974, pp. 21–52.Google Scholar
  113. GROS, R.: Control of gene expression in prokaryotic systems. FEBS Letters 40, (Suppl.) 19–27 (1974).Google Scholar
  114. GUERZONI, M.E.: Physiological and enzymatic aspects of histidine- mediated control of the tryptophan pathway. Arch. Mikrobiol. 86, 57–68 (1972).PubMedGoogle Scholar
  115. GUIDOTTI, A., HANBAUER, I., COSTRA, E.: Role of cyclic nucleotides in the induction of tyrosine hydroxylase. Advan. Cycl. Nucl. Res. 5, 619–639 (1975).Google Scholar
  116. HAAVIK, H.I., FROYSHOV, O.: Function of peptide antibiotics in producer organism. Nature (London) 254, 79–82 (1975).Google Scholar
  117. HAFFKE, S.C., SEEDS, N.W.: Neuroblastoma: The Escherichia coli of neurobiology? Life Sci. 16, 1649–1658 (1975).PubMedGoogle Scholar
  118. HAHLBROCK, K.: Regulation of phenylalanine ammonia-lyase activity in cell-suspension cultures of Petroselinum hortense. Apparent rates of enzyme synthesis and degradation. Europ. J. Biochem. 63, 137–145 (1976).PubMedGoogle Scholar
  119. HAHLBROCK, K.: Coordinated regulation of the enzymes of flavonoid biosynthesis. In: Cell Differentiation in Microorganisms, Plants and Animals. NOVER, L., MOTHES, K. (eds.). Jena-Amster- dam: VEB Fischer and Elsevier 1977, pp. 524–537.Google Scholar
  120. HAHLBROCK, K., EBEL, J., ORTMANN, R., SUTTER, A., WELLMANN, E., GRISEBACH, H.: Regulation of enzyme activities related to the biosynthesis of flavone glycosides in cell suspension cultures of Parsley (Petroselinum hortense). Biochim. Biophys. Acta 244, 7–15 (1971a).PubMedGoogle Scholar
  121. HAHLBROCK, K., KNOBLOCH, K.-H., KREUZALER, F., POTTS, J.R.M., WELLMANN, E.: Coordinated induction and subsequent activity changes of two groups of metabolically interrelated enzymes. Light-induced synthesis of flavonoid glycosides in cell suspension cultures of Petroselinum hortense. Europ. J. Biochem. 61, 199–206 (1976).PubMedGoogle Scholar
  122. HAHLBROCK, K., RAGG, H.: Light-induced changes of enzyme activities in parsley cell suspension cultures. Effects of inhibitors of RNA and protein synthesis. Arch. Biochem. Biophys. 166, 41–46 (1975).PubMedGoogle Scholar
  123. HAHLBROCK, K., SCHRÖDER, J.: Light-induced changes of enzyme activities in parsley cell suspension cultures. Increased rate of synthesis of phenylalanine ammonia lyase. Arch. Biochem. Biophys. 166/ 47–53 (1975).PubMedGoogle Scholar
  124. HAHLBROCK, K., SUTTER, A., WELLMANN, E., ORTMANN, R., GRISEBACH, H.: Relationship between organ development and activity of enzymes involved in flavone glycoside biosynthesis in young parsley plants. Phytochemistry 10, 109–116 (1971b).Google Scholar
  125. HAHLBROCK, K., WELLMANN, E.: Light-induced flavone biosynthesis and activity of phenylalanine ammonia-lyase and UDP-apiose synthetase in cell suspension cultures of Petroselinum hortense. Planta (Berlin) 94, 236–239 (1970).Google Scholar
  126. HAHLBROCK, K., WELLMANN, E.: Light-independent induction of enzymes related to phenylpropanoid metabolism in cell suspension cultures from parsley. Biochim. Biophys. Acta 304, 702–706 (1973).PubMedGoogle Scholar
  127. HAMILTON, T.H.: Control by estrogen of genetic transcription and translation. Science 161, 649–661 (1968).PubMedGoogle Scholar
  128. HAMKALO, B.A., MILLER, O.L.: Electronmicroscopy of genetic activity. Ann. Rev. Biochem. 42, 379–396 (1973).PubMedGoogle Scholar
  129. HANSON, R.S., PETERSON, J.A., YOUSTEN, A.A.: Unique biochemical events in bacterial sporulation.Ann. Rev. Microbiol. 24, 53–90 (1970).Google Scholar
  130. HARTLEY, M.R., WHEELER, A., ELLIS, R.J.: Protein synthesis in chloroplasts. V. Translation of mRNA for the large subunit of fraction I protein in a heterologous cell-free system. J. Mol. Biol. 91, 67–77 (1975).PubMedGoogle Scholar
  131. HATHOUT BASSIM, T.A., PECKET, R.C.: The effect of membrane stabilizers on phytochrome-controlled anthocyanin biosynthesis in Brassica oleracea. Phytochemistry 14, 731–733 (1975).Google Scholar
  132. HAYMAN, E.P., CHICHESTER, C.O., SIMPSON, K.L.: Effects of CPTA upon carotenogenesis and lipoidal constituents in Rhodotorula species. Phytochemistry 13, 1123–1127 (1974).Google Scholar
  133. HEINSTEIN, P.F., LEE, S.-L., FLOSS, H.G.: Isolation of dimethyl- ally lpyrophosphate: Tryptophan dimethylallyl transferase from the ergot fungus (Claviceps spec.). Biochem. Biophys. Res. Comm. 44, 1244–1251 (1971).PubMedGoogle Scholar
  134. HESLOP-HARRISON, J.: Sporopollenin in the biological context. In: Sporopollenin. BROOKS, J., GRANT, P.R., MUIR, M., VAN GIJ-ZEL, SHAW, G. (eds.). London: Academic Press 1971, pp. 1–30.Google Scholar
  135. HESS, D.: Die Wirkung von Zimtsäuren auf die Anthocyansynthese in isolierten Petalen von Petunia hybrida. Z. Pflanzenphysiol. 56, 12–19 (1967a).Google Scholar
  136. HESS, D.: Substratinduktion bei der Anthocyansynthese von Petunia. Naturwissenschaften 54, 289–290 (1967b).PubMedGoogle Scholar
  137. HESS, D.: Substratinduktionen durch Zimtsäuren als physiologischer Mechanismus bei der Einleitung der Anthocyansynthese. Z. Pflanzenphysiol. 59, 293–296 (1968).Google Scholar
  138. HESS, D., HADWIGER, L.A.: The induction of phenylalanine ammonia- lyase and phaseollin by 9-aminoacridine and other deoxyribonucleic acid intercalating compounds. Plant Physiol. 48., 197–202 (1971).PubMedGoogle Scholar
  139. HIPPEL, P.H. VON, McGHEE, J.D.: DNA-protein interactions. Ann. Rev. Biochem. 41, 231–300 (1972).Google Scholar
  140. HOLZER, H.: Regulatory role of proteinases and proteinase inhibitors in yeast. In: Mechanisms of Action and Regulation of Enzymes. KELETI, T. (ed.). Proc. 9th FEBS Meeting 32, 181–193. Budapest: Akadfemikai Kiado 1975.Google Scholar
  141. HOLTZER, H., ABOTT, J.: Oscillation of the chondrogenic pheno- type in vitro. In: The Stability of the Differentiated State. URSPRUNG, H. (ed.). Berlin-Heidelberg-New York: Springer 1968, pp. 1–16.Google Scholar
  142. HOLTZER, H., WEINTRAUB, H., BIEHL, J.: Cell cycle-dependent events during myogenesis, neurogenesis, and erythrogenesis. In: Biochemistry of Cell Differentiation. MONROY, A., TSANEV, R. (eds.). London: Academic Press 1973, pp. 41–53.Google Scholar
  143. HOROWITZ, J., SAUKKONEN, J.J., CHARGAFF, E.: Effects of fluoro- pyrimidines on the synthesis of bacterial proteins and nucleic acids. J. Biol. Chem. 235, 3266–3272 (1960).PubMedGoogle Scholar
  144. HU, A.S.L., BOCK, R.M., HALVORSON, H.O.: Separation of labeled from unlabeled proteins by equilibrium density gradient sedimentation. Anal. Biochem. 4, 489–504 (1962).PubMedGoogle Scholar
  145. HUA, S., MARKOVITZ, A.: Multiple regulation of the galactose operon - genetic evidence for a distinct site in the galactose operon that responds to capR gene regulation in Escherichia coli K-12. Proc. Nat. Acad. Sci. 71., 507–511 (1974).PubMedGoogle Scholar
  146. HUANG, P.C.: DNA, RNA and protein interactions. Progr. Biophys. Mol. Biol. 23, 103–144 (1972).Google Scholar
  147. HUANG, P.C., SMITH, M.M.: Nucleic acid hybridization and the nature of chromosomal protein bound RNA. In: Nucleic Acid Hybridization in the Study of Cell Differentiation. URSPRUNG, H. (ed.). Berlin-Heidelberg-New York: Springer 1972, pp. 65–76.Google Scholar
  148. HUEZ, G., MARBAIX, H., HUBERT, E., LECLERCQ, M., NUDEL, U., SOREQ, H., SALOMON, R., LEBLEU, B., REVEL, M., LITTAUER, U.Z.: Role of the polyadenylate segment in the translation of globin messenger RNA in Xenopus oocytes. Proc. Nat. Acad. Sci. 71, 3143–3146 (1974).PubMedGoogle Scholar
  149. IMAM0T0, F.: Translation and transcription of the tryptophan operon. Progr. Nucl. Acid. Res. Mol. Biol. 13, 339–407 (1973).Google Scholar
  150. INGLE, J.: The effect of light and inhibitors on chloroplast and cytoplasmatic RNA synthesis. Plant Physiol. 43., 1850–1854 (1968).Google Scholar
  151. ININGER, G., NOVER, L.: Regulation of 3-galactosidase formation in emerged cultures of Pénicillium cyclopium WESTLING. Biochem. Physiol. Pflanz. 167, 585–595 (1975).Google Scholar
  152. IREDALE, S.E., SMITH, H.: Properties of phenylalanine ammonia- lyase extracted from Cucumis sativus hypocotyls. Phytochemistry 13, 575–583 (1974).Google Scholar
  153. JANGAARD, N.O.: The characterization of phenylalanine ammonia- lyase from several plant species. Phytochemistry 13, 1765–1768 (1974).Google Scholar
  154. JANISTYN, B., DRUMM, H.: Phytochrome-mediated rapid changes of cyclic AMP in mustard seedling (Sinapis alba L.). Planta (Berlin) 115, 81–85 (1975).Google Scholar
  155. JENSEN, E.V., DE SOMBRE, E.R.: Estrogen receptor interaction. Science 182, 126–134 (1973).PubMedGoogle Scholar
  156. JENSEN, E.V., NUMATA, M., SMITH, S., SUZUKI, T., BRECHER, P.I., DE SOMBRE, E.R.: Estrogen-receptor interactions in target tissues. Dev. Biol. Suppl. 3, 151–171 (1969).Google Scholar
  157. JICINSKÂ, E.: Note on study of the sporulation of fungi: endo- trophic sporulation in the genus Pénicillium. Folia Microbiol. (Praha) 13, 401–409 (1968).Google Scholar
  158. JOBE, A., BOURGEOIS, S.: Lac repressor-operator interaction; VI: The natural inducer of the lac operon. J. Mol. Biol. 69, 397–408 (1972).PubMedGoogle Scholar
  159. JOH, T.H., GEGHMAN, C., REIS, D.: Immunochemical demonstration of increased accumulation of tyrosine hydroxylase protein in sympathetic ganglia and adrenal medulla elicited by reserpine. Proc. Nat. Acad. Sci. 70, 2767–2771 (1973).PubMedGoogle Scholar
  160. JOHNSON, C., ATTRIDGE, T., SMITH, H.: Regulation of phenylalanine ammonia-lyase synthesis by cinnamic acid; its implication of the light mediated regulation of the enzyme. Biochim. Biophys. Acta 385, 11–19 (1975).PubMedGoogle Scholar
  161. JONDORF, W.R., SIMON, D.C., AVNIMELECH, M.: Further studies on the stimulation of L- (l 14C) -amino acid incorporation with cyclo- heximide. Mol. Pharmacol. 2, 506–517 (1966).PubMedGoogle Scholar
  162. JONES, G.H., WEISSBACH, H.: RNA metabolism in Streptomyces anti- bioticus; Effect of 5-fluorouracil on the appearance of pheno- xazinone synthetase. Arch. Biochem. Biophys. 137, 558–573 (1970).PubMedGoogle Scholar
  163. JOST, J.P., RICKENBERG, H.V.: Cyclic AMP. Ann. Rev. Biochem. 40, 741–774 (1971).Google Scholar
  164. JUNGMANN, R.A., SHAW-GUANG LEE, DeANGELO, A.B.: Translocation of cytoplasmic protein kinase and cAMP-binding protein to intracellular acceptor sites. Advan. Cycl. Nucl. Res. 5, 281–306 (1975).Google Scholar
  165. KAMBE, M., IMAE, Y., KURABASHI, K.: Biochemical studies on gramicidin S non-producing mutants of Bacillus brevis ATCC 9999. J. Biochem. (Tokyo) 75, 481–493 (1974).Google Scholar
  166. KANE, J.F., HOLMES, W.M., JENSEN, R.A.: Metabolic interlock: The dual function of a folate pathway gene as an extra-operonic gene of tryptophan biosynthesis. J. Biol. Chem. 247, 1587–1596 (1972).PubMedGoogle Scholar
  167. KANG, B.G., NEWCOMB, W., BURG, S.P.: Mechanism of auxin-induced ethylene production. Plant Physiol. 47, 504–509 (1971).PubMedGoogle Scholar
  168. KANNANGARA, C.G., HENNINGSEN, K.W., STUMPF, P.K., WETTSTEIN, D. VON: 6-Methylsalicylic acid synthesis by isolated barley chloroplasts. Europ. J. Biochem. 21, 334–338 (1971).PubMedGoogle Scholar
  169. KAPLAN, H., HORNEMANN, U., KELLEY, K.M., FLOSS, H.G.: Tryptophan metabolism, protein and alkaloid synthesis in saprophytic cultures of the ergot fungus (Claviceps sp.). Lloydia 32, 489–497 (1969).PubMedGoogle Scholar
  170. KARABOYAS, G.C., KORITZ, S.B.: Identity of the site of action of 31, 51-adenosine monophosphate and adrenocorticotrophic hormone in corticosteroidogenesis in rat adrenal and beef adrenal cortex slices. Biochemistry 4, 462–468 (1965).Google Scholar
  171. KARLSON, P.: Hormonwirkung durch Genaktivierung. In: Mechanisms of Hormone Action. KARLSON, P. (ed.). Stuttgart: Thieme and New York: Academic Press 1965, pp. 139–141.Google Scholar
  172. KARLSON, P., MERGENHAGEN, D., SEKERIS, C.E.: Zum Tyrosinstoff- wechsel der Insekten, XV. Weitere Untersuchungen über das o- Diphenoloxydasesystem von Calliphora erythrocephala. Z. Physiol. Chem. 338/ 42–50 (1964).Google Scholar
  173. KARLSON, P., SCHWEIGER, A.: Zum Tyrosinstoffwechsel der Insekten, IV. Das Phenoloxydase-System von Calliphora und seine Beeinflussung durch das Hormon Ecdyson. Hoppe-Seyler1s Z. Physiol. Chem. 323/ 199–210 (1961).Google Scholar
  174. KARLSON, P., SEKERIS, C.E.: Zum Tyrosinstoffwechsel der Insekten, IX. Kontrolle des Tyrosinstoffwechsels durch Ecdyson. Biochim. Biophys. Acta 63, 489–495 (1962).Google Scholar
  175. KARLSON, P., SEKERIS, C.E., MARMARAS, V.I.: Die Aminosäurezusammensetzung verschiedener Proteinfraktionen aus der Cuticula von Calliphora erythrocephala in verschiedenen Entwicklungsstadien. J. Insect. Physiol. 15, 319–323 (1969).Google Scholar
  176. KAU, K.W., UNGAR, F.: Characterization of an adrenal activator for cholesterol side chain cleavage. J. Biol. Chem. 248, 2868- 2875 (1973).Google Scholar
  177. KEPES, A.: Transcription and translation in the lactose operon of Escherichia coli studied by in vivo kinetics. Progr. Biophys. Mol. Biol. 19, 199–236 (1969).Google Scholar
  178. KHOKHLOV, A.S., ANISOVA, L.N., TOVAROVA, I.I., KLEINER, E.M., KOVALENKO, I.V., KRASILNIKOVA, O.I., KORNITS KAYA, I.Y., PLINER, S.A.: Effect of A-factor on the growth of asporogenous mutants of Streptomyces griseus, not producing this factor. Z. Allg. Mikrobiol. 13, 647–655 (1973).PubMedGoogle Scholar
  179. KHOKHLOV, A.S., TOVAROVA, I.I., ANISOVA, L.N.: Regulators of streptomycin biosynthesis and development of Actinomyces strep-tomycini. In: Secondary Metabolism and Coevolution. LUCKNER, M., MOTHES, K., NOVER, L. (eds.). Nova Acta Leopoldina, Suppl. 7, 289–298 (1976).Google Scholar
  180. KHOKHLOV, A. S., TOVAROVA, I.I., BORISOVA, L.N., PLINER, S.A., SHEVCHENKO, L.A., KORNITSKAYA, E.J., IVKINA, N.S., RAPOPORT, I.A.: The A-factor responsible for the biosynthesis of streptomycin in mutant strains of Actinomyces streptomycini. Dokl. Akad. Nauk SSSR 177, 232–235 (1967).PubMedGoogle Scholar
  181. KILLEWICH, L., SCHUTZ, G., FEIGELSON, P.: Functional level of rat liver tryptophan 2, 3-dioxygenase messenger RNA during superinduction of enzyme with actinomycin D. Proc. Nat. Acad. Sci. 72, 4285–4287 (1975).PubMedGoogle Scholar
  182. KILLICK, K.A., WRIGHT, B.A.: Regulation of enzyme activity during differentiation in Dictyostelium dioscoideum. Ann. Rev. Microbiol. 28, 139–166 (1974).Google Scholar
  183. KIM, K.-H.: Nucleic acid hybridization to isolated chromatin. In: Nucleic Acid Hybridization in the Study of Cell Differentiation. URSPRUNG, H. (ed.). Berlin-Heidelberg-New York: Springer 1972, pp. 37–46.Google Scholar
  184. KLIER, A.F., LECADET, M.M., DEDONDER, R.: Sequential modifications of DNA-dependent RNA polymerase during sporogenesis in Bacillus thuringiensis. Europ. J. Biochem. 36., 317–327 (1973).PubMedGoogle Scholar
  185. KÖHLER, K.-H.: Kinetik der durch Inhibitoren des Protein- und Nukleinsäurestoffwechseis bewirkten Hemmung der Amaranthinbil- dung bei Amaranthus caudatus Keimlingen. Biochem. Physiol. Pflanz. 168, 1 13–122 (1975).Google Scholar
  186. KRUPINSKI, V.M., ROBBERS, J.E., FLOSS, H.G.: Physiological study of ergot: induction of alkaloid synthesis by tryptophan at the enzymatic level. J. Bact. 125, 158–165 (1976).PubMedGoogle Scholar
  187. KUNG, H.-F., SPEARS, C., WEISSBACH, H.: Purification and properties of a soluble factor required for the DNA-directed in vitro synthesis of 3-galactosidase. J. Biol. Chem. 250, 1556- 1562 (1975).PubMedGoogle Scholar
  188. KURAHASHI, K.: Biosynthesis of small peptides. Ann. Rev. Biochem. 43, 445–459 (1974).PubMedGoogle Scholar
  189. LANGE, H., MOHR, H.: Die Hemmung der Phytochrom-induzierten An- thocyansynthese durch Actinomycin D und Puromycin. Planta (Berlin) 67, 107–121 (1965).Google Scholar
  190. LANGE, H., SHROPSHIRE, W., MOHR, H.: An analysis of phytochrom- mediated anthocyanin synthesis. Plant Physiol. 47., 649–655 (1971).PubMedGoogle Scholar
  191. LANE, M.D., MÖSS, J.: Regulation of fatty acid synthesis in animal tissues. In: Metabolic Regulation. VOGEL, H.J. (ed.). New York- London: Academic Press 1971, pp. 23–54.Google Scholar
  192. LAWRENCE, P.: The cell cycle and cellular differentiation in insects. In: Cell Cycle and Cell Differentiation. BEERMANN, W., HOLTZER, H., REINERT, J., URSPRUNG, H. (eds.). Berlin- Heidelberg-New York: Springer 1975, pp. 111–121.Google Scholar
  193. LEE, S.G., LITTAU, V., LIPMANN, F.: The relation between sporu- lation and the induction of antibiotic synthesis and of amino acid uptake in Bacillus brevis. J. Cell Biol. 66, 233–242 (1975).PubMedGoogle Scholar
  194. LEIGHTON, T.J., DOI, R.H., WARREN, R.A.I., KELLN, R.A.: The relationship of serine protease activity to RNA polymerase modification and sporulation in Bacillus subtilis. J. Mol. Biol. 76, 103–122 (1973).PubMedGoogle Scholar
  195. LIEBERMANN, M., KUNISHI, A.T.: Ethylene-forming systems in etiolated pea seedling and apple tissue. Plant Physiol. 55, 1074- 1078 (1975).Google Scholar
  196. LIGHT, R.J.: Effects of cycloheximide and amino acid analogues on biosynthesis of 6-methylsalicylic acid in Pénicillium patu- lum. Arch. Biochem. Biophys. 122, 494–500 (1967).PubMedGoogle Scholar
  197. LIGHT, R.J.: 6-Methylsalicylic acid decarboxylase from Pénicillium pa tul um. Biochim. Biophys. Acta 191, 430–438 (1969).PubMedGoogle Scholar
  198. LIGHT, R.J.: Enzymatic studies on polyketide hypothesis. J. Agr. Food Chem. 18, 260–267 (1970).Google Scholar
  199. LINN, T.G., GREENLEAF, A.L., SHORENSTEIN, R.G., LOSICK, R.: Loss of the a-activity of RNA polymerase of Bacillus subtilis during sporulation. Proc. Nat. Acad. Sci. 70, 1865–1869 (1973).PubMedGoogle Scholar
  200. LIS, J.T., SCHLEIF, R.: The regulatory region of the L-arabinose operon: its isolation on a 1000 base-pair fragment from DNA heteroduplexes. J. Mol. Biol. 95, 409–416 (1975).PubMedGoogle Scholar
  201. LISSITZKY, S., FAYET, G., VERRIER, B.: Thyrotropin-receptor interaction and cAMP-mediated effects in thyroid cells. Advan. Cycl. Nucl. Res. 5, 133–152 (1975).Google Scholar
  202. LOCKWOOD, D.H., STOCKDALE, F.E., TOPPER, Y.Y.: Hormone dependent differentiation of mammary gland: Sequence of action of hormones in relation to cell cycle. Science 156, 945–946 (1967).PubMedGoogle Scholar
  203. LÖFFELHARDT, W., KINDL, H.: The conversion of L-phenylalanine into benzoic acid on the thylakoid membrane of higher plants. Hoppe-Sey1er1 s Z. Physiol. Chem. 356, 487–493 (1975).Google Scholar
  204. LÖFFELHARDT, W., LUDWIG, B., KINDL, H.: Thylakoid-gebundene L- Phenylalanin-Ammoniak-Lyase. Hoppe Seyler’s Z. Physiol. Chem. 354, 1006–1012 (1973).PubMedGoogle Scholar
  205. LOSICK, R.: In vitro transcription. Ann. Rev. Microbiol. 41, 409–446 (1972).Google Scholar
  206. LOSICK, R., PERO, J.: Bacillus subtilis RNA polymerase and its modification in sporulating and phage-infected bacteria. Adv. Enzymol. 44, 165–185 (1976).PubMedGoogle Scholar
  207. LUCKNER, M.: Was ist Sekundärstoffwechsel? Pharmazie 26, 717–724 (1971).PubMedGoogle Scholar
  208. LUCKNER, M.: Secondary Metabolism in Plants and Animals. London: Chapman and Hall Ltd. 1972.Google Scholar
  209. LUCKNER, M.: The integration of benzodiazepine and quinoline alkaloid formation into the developmental program of Pénicillium cyclopium. In: Cell Differentiation in Microorganisms, Plants and Animals. NOYER, L., MOTHES, K. (eds.). Jena and Amsterdam: VEB Fischer and Elsevier 1977, pp. 538–558.Google Scholar
  210. LUCKNER, M., MOTHES, K., NOVER, L.: Secondary metabolism and coevolution; cellular, intercellular and interorganismic aspects. Nova Acta Leopoldina, Suppl. 7 (1976).Google Scholar
  211. MACKENZIE, J.M., COLEMAN, R.A., BRIGGS, W.R., PRATT, L.H.: Reversible redistribution of phytochrome within the cell upon conversion to its physiologically active forms. Proc. Nat. Acad. Sci. 72, 799–803 (1975).PubMedGoogle Scholar
  212. MAGASANIK, B.: Regulation of the synthesis of degradative bacterial enzymes. In: Cell Differentiation in Microorganisms, Plants and Animals. NOVER, L., MOTHES, K. (eds.). Jena and Amsterdam: VEB Fischer and Elsevier 1977, pp. 438–460.Google Scholar
  213. MAGASANIK, B., PRIVAL, M.J., BRENCHLEY, J.E., TYLER, B.M., DE LEO, A.B., STREICHER, S.L., BENDER, R.A., PARIS, C.G.: Glutamine synthetase as a regulator of enzyme synthesis. Current Topics Cell. Regul. 8, 119 (1974).Google Scholar
  214. MAHAFFEE, E., REITZ, R.C., NEY, R.L.: The mechanism of action of adrenocorticotrophic hormone. J. Biol. Chem. 249, 227–233 (1974).PubMedGoogle Scholar
  215. MAILHAMMER, R., YANG, H.L., REINESS, G., ZUBAY, G.: Effects of bacteriophage T4-induced modification of Escherichia coli RNA polymerase on gene expression in vitro. Proc. Nat. Acad. Sci. 72, 4928–4932 (1975).PubMedGoogle Scholar
  216. MAJORS, J.: Initiation of in vitro mRNA synthesis from the wild- type lac promoter. Proc. Nat. Acad. Sci. 72, 4394–4398 (1975).PubMedGoogle Scholar
  217. MANCINELLI, A.L., YANG, C.H., LINDQUIST, P., ANDERSON, O.R., RABINO, I.: Photocontrol of anthocyanin synthesis. III. The action of streptomycin on the synthesis of chlorophyll and anthocyanin. Plant Physiol. 55, 251–257 (1972).Google Scholar
  218. MANDELSTAM, J.: Bacterial sporulation: a problem in the biochemistry and genetics of a primitive developmental system. Proc. Roy Soc. London B. 193, 89–106 (1976).Google Scholar
  219. MARMARAS, V.J., SEKERIS, C.E.: Pattern and activity of polyribosomes from the integument of blowfly larvae during development. Exp. Cell Res. 75, 143–153 (1972).PubMedGoogle Scholar
  220. MARSHALL, R., REDFIELD, B., KATZ, E., WEISSBACH, H.: Changes in phenoxazinone synthetase activity during the growth cycle of Streptomyces antibioticus. Arch. Biochem. Biophys. 123, 317–23 (1968).PubMedGoogle Scholar
  221. MARTINELLI, S.D.: Biochemical investigations on conidiation of Aspergillus nidulans in submerged liquid culture. Biochem. J. 127, 16 P (1972).Google Scholar
  222. MATCHETT, W.H., DEMOSS, J.A.: Physiological channeling of tryptophan in Neurospora crassa. Biochim. Biophys. Acta 86, 91–99 (1964).PubMedGoogle Scholar
  223. McCLURE, J.W.: Physiology and function of flavonoids. In: The Flavonoids. HARBORNE, J.B., MABRY, T.J., MABRY, H. (eds.). London: Chapman and Hall 1975, pp. 970–1055.Google Scholar
  224. McCLURE, J.W., GROSS, G.G.: Diverse photoinduction characteristics of hydroxycinnamate: Coenzyme A ligase and phenylalanine ammonia -lyase in dicotyledonous seedlings. Z. Pflanzenphysiol. 76, 51–55 (1975).Google Scholar
  225. McMAHON, D.: Cycloheximide is not a specific inhibitor of protein synthesis in vivo. Plant Physiol. 55., 815–821 (1975).PubMedGoogle Scholar
  226. MEINS, F.: Cell division and the determination phase of cyto- differentiation in plants. In: Cell Cycle and Cell Differentiation. BEERMANN, W., HOLTZER, H., REINERT, J., URSPRUNG, H. (eds.). Berlin-Heidelberg-New York: Springer 1975, pp. 151–175.Google Scholar
  227. MESLAND, D.A.M., HUISMAN, J.G., VAN DEN ENDE, H.: Volatile sexual hormones in Mucor mucedo. J. Gen. Microbiol. 80, 111–117 (1974).Google Scholar
  228. METZENBERG, R.L.: Genetic regulatory systems in Neurospora. Ann. Rev. Genetics 6, 111–132 (1972).Google Scholar
  229. MEYER, B.J., KLEID, D.G., PTASHNE, M.: X Repressor turns off transcription of its own gene. Proc. Nat. Acad. Sci. 72, 4785–4789 (1975).PubMedGoogle Scholar
  230. MITRAKOS, K., SHROPSHIRE, W. (eds.): Phytochrome. London: Academic Press 1972.Google Scholar
  231. MOHR, H., DRUMM, H., KASEMIR, H.: Licht und Farbstoffe. Ber. Deut. Botan. Ges. 87, 49–69 (1974).Google Scholar
  232. MOHR, H., SITTE, P.: Lectures on Photomorphogenesis. Berlin- Heidelberg-New York: Springer 1972.Google Scholar
  233. MOSCONA, A.A.: Induction of glutamine synthetase in embryonic neural retina: a model for the regulation of specific gene expression in embryonic cells. In: Biochemistry of Cell Differentiation. MONROY, A., TSANEV, R. (eds.). London-New York: Academic Press 1973, pp. 1–23.Google Scholar
  234. MOSCONA, M., FRENKEL, N., MOSCONA, A.A.: Regulatory mechanisms in the induction of glutamine synthetase in the embryonic retina: Immunochemical studies. Develop. Biol. 28, 229–241 (1972).PubMedGoogle Scholar
  235. MOTHES, K.: Vergleichende Betrachtung des pflanzlichen Stoffwechsels. In: Physiologische Chemie. FLASCHENTRÄGER, B., LEHNART Z, E. (eds.). Berlin-Heidelberg-New York: Springer 1966a, Vol. 11/2d/B, pp. 971–975.Google Scholar
  236. MOTHES, K.: Zur Problematik der metabolischen Exkretion bei Pflanzen. Naturwissenschaften 53, 317–323 (1966b).PubMedGoogle Scholar
  237. MOTHES, K.: über sekundäre Pflanzenstoffe. Abh. sächs. Akad. Wiss. Leipzig, math.-naturwiss. Klasse 52, 3–29 (1972).Google Scholar
  238. MÜNTZ, K., HORSTMANN, C., SCHOLZ, G.: Proteine und Proteinbiosynthese in Samen von Vicia faba L. Kulturpflanze 20, 277–326 (1972).Google Scholar
  239. MURPHY, G., LYNEN, F.: Patulin biosynthesis. The metabolism of m-hydroxybenzyl alcohol and m-hydroxybenzaldehyde by particulate preparations from Pénicillium patulum. Europ. J. Biochem. 58, 467–475 (1975).PubMedGoogle Scholar
  240. NASON, A., EVANS, H.J.: TPN-nitrate reductase in Neurospora: Inducibility of nitrate reductase. J. Biol. Chem. 202, 655–673 (1953).PubMedGoogle Scholar
  241. NEBERT, D.W., GIELEN, J.E., GOUJON, F.M.: Genetic expression of aryl hydrocarbon hydroxylase induction. 3. Changes in the binding of n-octylamine to cytochrome P 450. Mol. Pharmacol. 8, 651 666 (1972).Google Scholar
  242. NEGBI, M., HOPKINS, D.W., BRIGGS, W.R.: Acceleration of dark reversion of phytochrome in vitro by calcium and magnesium. Plant Physiol. 56, 157–159 (1975).PubMedGoogle Scholar
  243. NOVER, L., MÜLLER, W.: Influence of cycloheximide on the expression of alkaloid metabolism in partially synchronized emerged cultures of Pénicillium cyclopium WESTLING. FEBS Letters 50, 17–20 (1975).PubMedGoogle Scholar
  244. NOVER, L., LUCKNER, M.: Mixed functional oxygenations during the biosynthesis of cyclopenin and cyclopenol, benzodiazepine alkaloids of Pénicillium cyclopium WESTLING. FEBS Letters 3, 292–296 (1969).PubMedGoogle Scholar
  245. NOVER, L., LUCKNER, M.: Expression of secondary metabolism as part of the differentiation processes during the idiophase development of Pénicillium cyclopium WESTLING. Biochem. Physiol Pflanz. 166, 293–305 (1974).Google Scholar
  246. NOVER, L., LUCKNER, M.: Influence of inhibitors of gene expression on processes of cell specialization in Pénicillium cyclopium WESTLING. In: Secondary Metabolism and Coevolution. LUCKNER, M., MOTHES, K., NOVER, L. (eds.). Nova Acta Leopoldina, Suppl. 7, 229–241 (1976).Google Scholar
  247. OELZE-KAROW, H., MOHR, H.: Experiments regarding the problem of differentiation in multicellular systems. Z. Naturforsch. 25b, 1282–1286 (1970).Google Scholar
  248. O’MALLEY, B.W., MEANS, A.R.: Female steroid hormones and target cell nuclei. Science 183, 610–620 (1974).PubMedGoogle Scholar
  249. ORNSTON, L.N.: Regulation of catabolic pathways in Pseudomonas. Bact. Rev. 35., 87–116 (1971).PubMedGoogle Scholar
  250. OTA, Y., OHTA, T., IMAHORI, K.: The differentiation in the availabilities of initiation points of phage RNA cistrons in their translation. J. Biochem. 71, 743–746 (1972).PubMedGoogle Scholar
  251. PACKTER, N.M., COLLINS, J.S.: Effect of inhibitors of protein synthesis on the formation of phenols derived from acetate and shikimic acid in Aspergillus fumigatus. Europ. J. Biochem. 42, 291–302 (1974).PubMedGoogle Scholar
  252. PAECH, K.: Biochemie und Physiologie der sekundären Pflanzenstoffe. Berlin-Göttingen-Heidelberg: Springer 1950.Google Scholar
  253. PALADE, G.E.: Intracellular aspects of the process of protein synthesis. Science 189, 347–358 (1975).PubMedGoogle Scholar
  254. PALMITER, R.D., CAREY, N.H.: Rapid inactivation of ovalbumin messenger ribonucleic acid after acute withdrawel of estrogen. Proc. Nat. Acad. Sci. 71, 2357–2361 (1974).PubMedGoogle Scholar
  255. PARTHIER, B: Existenz und Realisierung extrachromosomaler genetischer Information in Piastiden und Mitochondrien. Biol. Rundschau 8, 289–306 (1970).Google Scholar
  256. PARTHIER, B., KRAUSPE, R., MUNSCHE, D., WOLLGIEHN, R.: The biogenesis of chloroplasts. In: The Chemistry and Biochemistry of Plant Proteins. HARBORNE, J.B., VAN SÜMERE, C.F. (eds.). New York-London: Academic Press 1975, pp. 167–270.Google Scholar
  257. PASTAN, I., PERLMAN, R.: Cyclic adenosine monophosphate in bacteria. Science 169, 339–344 (1970).PubMedGoogle Scholar
  258. PAUL, J., GILMOUR, R.S.: The regulatory role of non-histone proteins in RNA synthesis. Ciba Foundation Symp. 28, 181–198 (1975).Google Scholar
  259. PAULUS, H., SARKAR, N.: Peptide antibotics as regulatory effectors during bacterial sporulation. Nova Acta Leopoldina, Suppl. 7, 357–373 (1976).Google Scholar
  260. PECKET, R.C., HATHOUT BASSIM, T.A.: The effect of kinetin in relation to photocontrol of anthocyanin biosynthesis in Brassica oleracea. Phytochemistry 13, 1395–1399 (1974).Google Scholar
  261. PERO, J., NELSON, J., FOX, T.D.: Highly asymmetric transcription by RNA polymerase containing phage-SPO1-induced polypeptides and a new host protein. Proc. Nat. Acad. Sci. 72, 1589–1593 (1975).PubMedGoogle Scholar
  262. PESTKA, S.: Inhibitors of ribosome functions. Ann. Rev. Biochem. 40, 697–710 (1971)Google Scholar
  263. PESTKA, S. Ann. Rev. Microbiol. 25, 487–562 (1971).Google Scholar
  264. PIATTELLI, M., GIUDICI DE NICOLA, M., CASTROGIOVANNI, V.: The Effect of kinetin on amaranthin synthesis in Amaranthus tricolor in darkness. Phytochemistry 10, 289–293 (1971).Google Scholar
  265. PIGGOT, P.J.: Mapping of asporogenous mutations of Bacillus subtilis: a minimum estimate of the number of sporulation operons. J. Bacteriol. 114, 1241–1253 (1973).PubMedGoogle Scholar
  266. PINE, M.J.: Turnover of intracellular proteins. Ann. Rev. Microbiol. 16, 103–126 (1972).Google Scholar
  267. PIRROTTA, V.: Sequence of the Or operator phage X. Nature (London) 254/ 114–117 (1975).Google Scholar
  268. POLING, S.M., HSU, W.-J., YOKOYAMA, H.: Structure-activity relationships of chemical inducers of carotenoid biosynthesis. Phytochemistry 14, 1933–1938 (1975).Google Scholar
  269. POYTON, R.O., GROOT, G.S.P.: Biosynthesis of polypeptides of cytochrome C oxidase by isolated mitochondria. Proc. Nat. Acad Sci. 72, 172–176 (1975).PubMedGoogle Scholar
  270. QUAST, L., WIERMANN, R.: über das Vorkommen verschieden substitu ierter Chalkone während der Mikrosporogenese bei Tulipa. Ex- perientia 29, 1165–1166 (1973).Google Scholar
  271. RABINOWITCH, H.D., RUDICH, J.: Effects of ethephon and CPTA on color development of tomato fruits at high temperature. Hort. Sci. 7, 76–77 (1972).Google Scholar
  272. RANJEVA, R., BOUDET, A.M., HARADA, H., MARIGO, G.: Phenolic metabolism in petunia tissues. I. Characteristic responses of enzymes involved in different steps of polyphenol synthesis to different hormonal influences. Biochim. Biophys. Acta 399, 23–30 (1975).PubMedGoogle Scholar
  273. RAO, K.K., PATEL, V.P.: Effect of tryptophan and related compounds on alkaloid formation in Aspergillus fumigatus. Lloydia 37, 608–610 (1974).PubMedGoogle Scholar
  274. RAST, D., SKřTVANOVA, R., BACHOFEN, R.: Replacement of light by dibutyryl-cAMP and cAMP in betacyanin synthesis. Phytochemistry 12, 2669–2672 (1973).Google Scholar
  275. REXER, B., SRINIVASAN, V.R., ZILLIG, W.: Regulation of transcription during sporulation of Bacillus cereus T. Europ. J. Bio- chem. 53, 271–281 (1975).Google Scholar
  276. RHAESE, H.-J., GROSCURTH, R.: Control of development: Role of regulatory nucleotides synthesized by membranes of Bacillus subtilis in initiation of sporulation. Proc. Nat. Acad. Sci. 73, 331–335 (1976).PubMedGoogle Scholar
  277. RICHMOND, M.H.: Enzymic adaptation in bacteria: its biochemical and genetic basis. Essays in Biochemistry 4, 105–154 (1968).PubMedGoogle Scholar
  278. RICHTER, I., LUCKNER, M.: Cyclopenin m-hydroxylase - an enzyme of alkaloid metabolism in Penicillium cylcopium. Phytochemistry 15, 67–70 (1976).Google Scholar
  279. RICKENBERG, H.V.: Cyclic AMP in prokaryotes. Ann. Rev. Microbiol. 28, 353–369 (1974).Google Scholar
  280. RICKWOOD, D., BIRNIE, G.A.: Metrizamide, a new density-gradient medium. FEBS Letters 50, 102–110 (1975).PubMedGoogle Scholar
  281. RISTOW, H.-J., SCHAZSCHNEIDER, B., BAUER, K., KLEINKAUF, H.: Tyrocidine and the linear gramicidin. Do these peptide antibiotics play an antagonistic regulative role in sporulation? Biochim. Biophys. Acta 390, 246–252 (1975a).Google Scholar
  282. RISTOW, H.-J., SCHAZSCHNEIDER, B., BAUER, K.: Effects of the peptide antibiotics tyrocidine and the linear gramicidin on RNA synthesis and sporulation of Bacillus brevis. Biochem. Biophys. Res. Commun. 63, 1085–1092 (1975b).PubMedGoogle Scholar
  283. RISTOW, H.-J., SCHAZSCHNEIDER, B., VATER, J., KLEINKAUF, H.: Some characteristics of the DNA-tyrocidine complex and a possible mechanism, of the gramicidin action. Biochim. Biophys. Acta 414, 1–8 (1975c).PubMedGoogle Scholar
  284. ROBBERS, J.E., FLOSS, H.G.: Induction by tryptophan of the enzymes of ergot alkaloid biosynthesis. Nova Acta Leopoldina, Suppl. 7, 243–269 (1976).Google Scholar
  285. ROBBERS, J.E., ROBERTSON, L.W., HORNEMANN, K.M., JINDRA, A., FLOSS, H.G.: Physiological studies on ergot: Further studies on the induction of alkaloid synthesis by tryptophan and its inhibition by phosphate. J. Bacteriol. VV2, 791–796 (1972).Google Scholar
  286. SAIER, M.H., FEUCHT, B.U., McCAMAN, M.T.: Regulation of intracellular adenosine cyclic 31, 51-monophosphate levels in Esche- richia coli and Salmonella typhimurium. J. Biol. Chem. 250, 7593–7601 (1975).PubMedGoogle Scholar
  287. SAKAI, S., IMASEKI, H.: Auxin-induced ethylene production by mungbean hypocotyl segments. Plant Cell Physiol. 12, 349–359 (1971).Google Scholar
  288. SARKAR, N., PAULUS, H.: Function of peptide antibiotics in sporu- lation. Nature (New Biol.) 139, 228–230 (1972).Google Scholar
  289. SARKAR, P.K., MOSCONA, A.A.: Glutamine synthetase induction in embryonic neural retina: Immunochemical identification of polysomes involved in enzyme synthesis. Proc. Nat. Acad. Sci. 70, 1667–1671 (1973).PubMedGoogle Scholar
  290. SAUNDERS, J.A., McCLURE, J.W.: Phytochrome controlled phenylalanine ammonia lyase in Hordeum vulgare plastids. Phytochem- istry 14, 1285–1289 (1975).Google Scholar
  291. SCHÄFER, E.: Evidence for binding of phytochrome to membranes. In: Membrane Transport in Plants. ZIMMERMANN, U., DAINTY, J. (eds.). Berlin-Heidelberg-New York: Springer 1974, pp. 435–440.Google Scholar
  292. SCHAZSCHNEIDER, B., RISTOW, H., KLEINKAUF, H.: Interaction between the antibiotic tyrocidine and DNA in vitro. Nature (London) 249, 757–759 (1974).Google Scholar
  293. SCHERRER, K.: Formation and regulation of mRNA in animal cells. In: Regulation of transcription and Translation in Eukaryotes. BAUTZ, E.K.F., KARLSON, P., KERSTEN, H. (eds.). Berlin-Heidel- berg-New York: Springer 1973, pp. 81–104.Google Scholar
  294. SCHIFF, J.A.: The control of chloroplast differentiation in Euglena. In: Proc. 3rd Int. Congr. Photosynthesis. AVRON, M. (ed.). Amsterdam: Elsevier 1974, pp. 1691–1717.Google Scholar
  295. SCHIMKE, R.T.: Control of enzyme levels in mammalian tissues. Advan. Enzymol. 37, 135–187 (1973).Google Scholar
  296. SCHOPFER, P., BAJRACHARYA, D., FALK, H., THIEN, W.: Phytochrom- gesteuerte Entwicklung von Zellorganellen (Plastiden, Micro- bodies, Mitochondrien). Ber. Deut. Botan. Ges. 88, 245–268 (1975).Google Scholar
  297. SCHOPFER, P., PLACHY, C.: Determination by phytochrome of enzyme development. Nova Acta Leopoldina, Suppl. 7, 327–334 (1976).Google Scholar
  298. SCHULSTER, D.: Adrenocorticotrophic hormone and the control of adrenal corticosteroidogenesis. Advan. Steroid Biochem. Pharmacol. 4, 233–295 (1974).Google Scholar
  299. SCHWEIGER, A., KARLSON, P.: Zum Tyrosinstoffwechsel der Insekten, X. Die Aktivierung der Präphenoloxydase und das Aktivator- Enzym. Z. Physiol. Chem. 319, 210–221 (1962).Google Scholar
  300. SEITZ, U., HEINZMANN, U.: Einfluß der Gibberellinsäure A3 auf die Anthocyansynthese der Kalluskulturen von Daucus carota. Planta Med. (Stuttgart) Suppl. 66–69 (1975).Google Scholar
  301. SEKERIS, C.E.: Action of eedysone on RNA and protein metabolism in the blowfly, Calliphora erythrocephala. In: Mechanisms of Hormone Action. KARLSON, P. (ed.). Stuttgart: Thieme and New York: Academic Press 1965, pp. 149–167.Google Scholar
  302. SEKERIS, C.E.: Die Wirkung von Hormonen auf den Zellkern. Chemie in unserer Zeit 3, 171–177 (1969).Google Scholar
  303. SEKERIS, C.E., KARLSON, P.: On the mechanism of hormone action, II. Ecdysone and protein biosynthesis. Arch. Biochem. Biophys. 105, 483–487 (1964).PubMedGoogle Scholar
  304. SEKERIS, C.E., MERGENHAGEN, D.: Phenoloxidase system of the blowfly, Calliphora erythrocephala. Science 145, 68–69 (1964).PubMedGoogle Scholar
  305. SERCARZ, E.E., GORINI, L.: Different contribution of exogenous and endogenous arginine to repressor formation. J. Mol. Biol 8, 254–262 (1964).PubMedGoogle Scholar
  306. SEYAMA, N., SPLITTSTOESSER, W.E.: Pigment synthesis in Cucurbita moschata cotyledons as influenced by CPTA and several inhibitors. Plant Cell Physiol. 16, 13–19 (1975).Google Scholar
  307. SHAAYA, E., SEKERIS, C.E.: Inhibitory effects of a-amanitin on RNA synthesis and induction of DOPA-decarboxylase by $-ecdysone. FEBS Letters 16., 333–336 (1971).PubMedGoogle Scholar
  308. SHAPIRO, D.J., SCHIMKE, R.T.: Immunochemical isolation and characterization of ovalbumin messenger ribonucleic acid. J. Biol. Chem. 250, 1759–1764 (1975).PubMedGoogle Scholar
  309. SHAW, G.: The chemistry of sporopollenin. In: Sporopollenin. BROOKS, J., GRANT, P.R., MUIR, M., VAN GIJZEL, P., SHAW, G. (eds.). London: Academic Press 1971, pp. 305–348.Google Scholar
  310. SHOWE, M.K., DE MOSS, J.A.: Localization and regulation of nitrate reductase in Escherichia coli. J. Bacteriol. 95, 1305–1313 (1968).PubMedGoogle Scholar
  311. SILVER, M.J., SMITH, J.B.: Prostaglandins as intracellular messengers. Life Sci. 16., 1635–1648 (1975).Google Scholar
  312. SMILLIE, R.M., SCOTT, N.S.: Organelle biosynthesis: The chloro- plast. Progr. Mol. Subcell. Biol. 136–202 (1969).Google Scholar
  313. SMITH, H.: The photocontrol of flavonoid biosynthesis. In: Phyto- chrome. MITRAKOS, K., SHROPSHIRE, W. (eds.). London: Academic Press 1972, pp. 433–481.Google Scholar
  314. SMITH, H.: Regulatory mechanisms in the photocontrol of flavonoid biosynthesis. In: Biosynthesis and Its Control in Plants. MIL- BORROW, B.V. (ed.). London-New York: Academic Press 1973, pp. 303–321.Google Scholar
  315. SONDHEIMER, E., SIMEONE, J.B. (eds.): Chemical Ecology. New York: Academic Press 1970.Google Scholar
  316. STAFFORD, H.A.: Possible multienzyme complexes regulating the formation of Cg-C3 phenolic compounds and lignins in higher plants. In: Metabolism and Regulation of Secondary Plant Products. RUNECKLES, V.C., CONN, E.E. (eds.). New York: Academic Press 1974, pp. 53–79.Google Scholar
  317. STANLEY, R.G., LINSKENS, H.F.: Pollen: Biology, Biochemistry, Management. Berlin-Heidelberg-New York: Springer 1974.Google Scholar
  318. STEFFENSEN, D.M., WIMBER, D.E.: Hybridization of nucleic acids -to chromosomes. In: Nucleic Acid Hybridization in the Study of Cell Differentiation. URSPRUNG, H. (ed.). Berlin-Heidelberg- New York: Springer 1972, pp. 47–63.Google Scholar
  319. STEPHENS, J.C., ARZT, S.W., AMES, B.N.: Guanosine 51-diphosphate- 31-diphosphate (ppGpp): positive effector for histidine operon transcription and general signal for amino-acid deficiency. Proc. Nat. Acad. Sci. 72, 4389–4393 (1975).PubMedGoogle Scholar
  320. STERLINI, J.M., MANDELSTAM, J.: Commitment to sporulation in Bacillus subtilis and its relationship to development of actino- mycin resistance. Biochem. J. 113, 29–37 (1969).PubMedGoogle Scholar
  321. SUGIYAMA, T., KORANT, B.D., LONBERG-HOLM, K.K.: RNA virus gene expression and its control. Ann. Rev. Microbiol. 26, 468–502 (1972).Google Scholar
  322. SÜTFELD, R., WIERMANN, R.: Die Bildung von Coenzym A-Thiolestern verschieden substituierter Zimtsäuren durch Enzymextrakte aus Antheren. Z. Pflanzenphysiol. 72, 163–171 (1974).Google Scholar
  323. SUTHERLAND, E.W.: Studies on the mechanism of hormone action. Science 177, 401–408 (1972).PubMedGoogle Scholar
  324. SUTTER, R.P.: Mutations affecting sexual development in Phyco- myces blakesleeanus. Proc. Nat. Acad. Sci. 72, 127–130 (1975).PubMedGoogle Scholar
  325. SZYBALSKI, W.: A network of developmental controls in coliphage lambda. In: Cell Differentiation in Microorganisms, Plants and Animals. NOVER, L., MOTHES, K. (eds.). Jena and Amsterdam: VEB Fischer and Elsevier 1977, pp. 262–316.Google Scholar
  326. SZYBALSKI, W., BOVRE, K., FIANDT, M., HAYES, S., HRADECNA, Z., KUMAR, S., LOZERON, H.H., NIJKAMP, H.J.J., STEVENS, W.F.:2 Transcriptional units and their control in Escherichia coli phage X: Operons and scriptons. Cold Spring Harbor Symp. Quant. Biol. 35, 341–354 (1970).Google Scholar
  327. TATA, J.R.: Regulation of protein synthesis by growth and developmental hormones. In: Biochemical Actions of Hormones. LITWACK, G., (ed.). New York: Academic Press 1970, pp. 89–133.Google Scholar
  328. THIEN, W., SCHOPFER, P.: Control by phytochrome of cytoplasmic and plastid rRNA accumulation in cotyledons of mustard seedlings in the absence of photosynthesis. Plant Physiol. 56, 660–664 (1975).PubMedGoogle Scholar
  329. THOMAS, D.M., HARRIS, R.C., KIRK, J.T.O., GOODWIN, T.W.: Studies on carotenogenesis in Blakeslea trispora, II. The mode of action of trisporic acid. Phytochemistry 6, 361–366 (1967).Google Scholar
  330. THOMAS, R.L., JEN, J.J.: Phytochrome-mediated carotenoid biosynthesis in ripening tomatoes. Plant Physiol. 50, 452–453 (1975).Google Scholar
  331. TOMKINS, G.M., GELEHRTER, T.D., GRANNER, D., MARTIN, D., SAMUELS, H., THOMPSON, E.B.: Control of specific gene expression in higher organisms. Science 166, 1474–1480 (1969).PubMedGoogle Scholar
  332. TOMKINS, G.M., LEVINSON, B.B., BAXTER, J.D., DETZLEFSEN, L.: Further evidence for postranscriptional control of inducible tyrosine aminotransferase synthesis in cultures of hepatoma cells. Nature (New Biol.) 239, 9–14 (1972).Google Scholar
  333. TOVAROVA, I.I., KORNITSKAYA, E.J., PLINER, C.A., SHEVCHENKO, L.A., ANISOVA, L.N., KHOKHLOV, A.S.: On the role of the A-fac- tor in the biosynthesis of streptomycin. Izvest. Akad. Nauk SSSR, Ser. Biol. No. 3, 427–434 (1970).Google Scholar
  334. TRAN THANH VAN, M., CHLYAH, H., CHLYAH, A.: Regulation of organogenesis in thin layers of epidermal and sub-epidermal cells. In: Tissue Culture and Plant Science. STREET, H.E. (ed.). London: Academic Press 1974, pp. 101–139.Google Scholar
  335. TSAI, M.-J., O’MALLEY, B.W.: Effects of estrogen on gene expression in chick oviduct. In: Cell Differentiation in Microorganisms, Plants and Animals. NOVER, L., MOTHES, K. (eds.). Jena and Amsterdam: VEB Fischer and Elsevier 1977, pp. 109–125.Google Scholar
  336. TUAN-HUA HO, D., VARNER, J.E.: Hormonal control of messenger ribonucleic acid metabolism in barley aleurone layers. Proc. Nat. Acad. Sci. 11, 4783–4786 (1974).Google Scholar
  337. TYLER, B., DELEO, A., MAGASANIK, B.: Activation of transcription of hut DNA by glutamine synthetase. Proc. Nat. Acad. Sci. 71, 225–229 (1974).PubMedGoogle Scholar
  338. UMBARGER, H.E.: Regulation of amino acids metabolism. Ann. Rev. Biochem. 38, 323–370 (1969).PubMedGoogle Scholar
  339. VAN DEN ENDE, H., WERKMAN, B.A., VAN DEN BRIEL, M.L.: Trisporic acid synthesis in mated cultures of the fungus Blakeslea trispora. Arch. Mikrobiol. 86, 175–184 (1972).PubMedGoogle Scholar
  340. VAN DEN ENDE, H., WIECHMAN, A.H.C.A., REYNGOUD, D.J., HENDRIKS, T.: Hormonal interactions in Mucor mucedo and Blakeslea trispora. J. Bacteriol. 101, 423–428 (1970).PubMedGoogle Scholar
  341. VAUGHAN, M.H., PAWLOWSKI, P.J., FORCHNAMMER, J.: Regulation of protein synthesis initiation in HeLa cells deprived of single essential amino acids. Proc. Nat. Acad. Sci. 68, 2057–2061 (1971).PubMedGoogle Scholar
  342. VERMA, D.P.S., MACLACHLAN, G.A., BYRNE, H., EWINGS, D.: Regulation and in vitro translation of m-RNA for cellulase from auxin- treated pea epicotyls. J. Biol. Chem. 250, 1019–1026 (1975).PubMedGoogle Scholar
  343. VOGEL, H.J. (ed.): Metabolie Regulation. New York-London: Academic Press 1971.Google Scholar
  344. VOIGT, S., LUCKNER, M.: Dehydrocyclopeptine epoxidase, a mixed function oxygenase of the alkaloid metabolism of Penicillium cyclopium. Phytochemistry, in press.Google Scholar
  345. WAITES, W.M., KAY, D., DAWES, I.W., WOOD, D.A., WARREN, S.C., MANDELSTAM, J.: Sporulation in Bacillus subtilis. Correlation of biochemical events with morphological changes in asporo- genous mutants. Biochem. J. 118, 667–676 (1970).PubMedGoogle Scholar
  346. WALTON, D.C., SOOFI, G.S., SONDHEIMER, E.: The effects of abscis- sic acid on growth and nucleic acid synthesis in excised embryonic bean axes. Plant Physiol. 45, 37–40 (1970).PubMedGoogle Scholar
  347. WALZ, A., PIRROTTA, V.: Sequence of the PR promoter of phage X. Nature (London) 254, 118–121 (1975).Google Scholar
  348. WARD, A.C., PACKTER, N.M.: Relationship between fatty-acid and phenol synthesis in Aspergillus fumigatus. Europ. J. Biochem. 46, 323–333 (1974).PubMedGoogle Scholar
  349. WEINBERG, E.D.: Biosynthesis of secondary metabolites: Role of trace metals. Advan. Microbiol. Physiol. 4, 1–44 (1970).Google Scholar
  350. WEINBERG, E.D., TONNIS, S.M.: Action of chloramphenicol and its isomers on secondary biosynthetic processes of Bacillus. Appl. Microb. 14, 850–856 (1966).Google Scholar
  351. WEINBERG, E.D., TONNIS, S.M.: Role of manganese in biosynthesis of bacitracin. Can. J. Microb. 13, 614–615 (1967).Google Scholar
  352. WEINTRAUB, H.: The organization of red cell differentiation. In: Cell Cycle and Cell Differentiation. BEERMANN, W., HOLTZER, H., REINERT, J., URSPRUNG, H. (eds.). Berlin-Heidelberg-New York: Springer 1975, pp. 27–42.Google Scholar
  353. WEISENSEEL, M., HAUPT, W.: The photomorphogenic pigment phyto- chrome: a membrane effector? In: Membrane Transport in Plants. ZIMMERMANN, U., DAINTY, J. (eds.). Berlin-Heidelberg-New York: Springer 1974, pp. 427–434.Google Scholar
  354. WELLMANN, E.: Regulation der Flavonoidbiosynthese durch ultraviolettes Licht und Phytochrom in Zellkulturen und Keimlingen von Petersilie (Petroselinum hortense Hoffm.). Ber. Deut. Botan. Ges. 87, 257–273 (1974).Google Scholar
  355. WELLMANN, E.: UV dose-dependent induction of enzymes related to flavonoid biosynthesis in cell suspension cultures of parsley. FEBS Letters 51, 105–107 (1975).PubMedGoogle Scholar
  356. WELLMANN, E., SCHOPFER, P.: Phytochrome mediated de novo synthesis of phenylalanine ammonia-lyase in cell suspension cultures of parsley. Plant Physiol. 55, 822–827 (1975).PubMedGoogle Scholar
  357. WERKMAN, T.A., VAN DEN ENDE, H.: Trisporic acid synthesis in Blakeslea trispora. Interaction between plus and minus mating types. Arch. Mikrobiol. 90, 365–374 (1973).Google Scholar
  358. WIERMANN, R.: über die Beziehungen zwischen flavonolaufbauenden Enzymen, einem flavonolumwandelnden Enzym und der Akkumulation phenylpropanoider Verbindungen während der Antherenentwicklung. Planta (Berlin) 110, 353–360 (1973).Google Scholar
  359. WILCOX, G., MEURIS, P., BASS, R., ENGLESBERG, E.: Regulation of the L-arabinose operon BAD in vitro. J. Biol. Chem. 249, 2946- 2952 (1974).PubMedGoogle Scholar
  360. WILKINSON, D.S., PITOT, H.C.: Inhibition of ribosomal RNA maturation in Novikoff hepatoma cells by 5-fluorouracil and 5-fluoro- uridine. J. Biol. Chem. 248, 63–68 (1973).PubMedGoogle Scholar
  361. WILSON, S., SCHMIDT, I., ROOS, W., FÜRST, W., LUCKNER, M.: Quantitative Bestimmung des Enzyms Cyclopenase in Konidiosporenvon Pénicillium cyclopium WESTLING und Pénicillium viridicatum WESTLING. Z. Allg. Mikrobiol. 14, 515–523 (1974).PubMedGoogle Scholar
  362. WILSON, S., LUCKNER, M.: Cyclopenase, ein Lipoproteid der Protoplasmamembran von Konidiosporen des Pilzes Pénicillium cyclopium WESTLING. Z. Allg. Mikrobiol. 15, 45–51 (1975).Google Scholar
  363. WOO, S.L.C., O’MALLEY, B.W.: Hormone inducible messenger RNA review. Life Sci. 17, 1039–1048 (1975).PubMedGoogle Scholar
  364. WOOD, D.A.: Sporulation in Bacillus subtilis. The appearance of sulpholactic acid as a marker event for sporulation. Biochem. J. 123, 601–605 (1971).PubMedGoogle Scholar
  365. YALOW, R.S., BERSON, S.A.: Immunoassay of plasma insulin. Methods Biochem. Anal.12, 69–96 (1964).Google Scholar
  366. ZENK, M.H., EL-SHAGI, H., SCHULTE, U.: Anthraquinone production by cell suspension cultures of Morinda citrifolia. Planta Med. (Stuttgart) Suppl.79–101 (1975).Google Scholar
  367. ZUCKER, M.: Light and enzymes. Ann. Rev. Plant Physiol. 23., 133–156 (1972)Google Scholar

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