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Chemical Structure and Biological Activities of Murine Histocompatibility Antigens

  • Conference paper
The Immune System

Part of the book series: Colloquium der Gesellschaft für Biologische Chemie ((MOSBACH,volume 27))

  • 195 Accesses

Abstract

Histocompatibility antigens are glycoproteins found on the surface membranes of vertebrate cells. The significance of these antigens in the rejection of allografts between individuals has been well established (1), and the genetics of these polymorphic systems have been studied in detail in the mouse (H-2) and in man (HL-A). The segment of the 17th chromosome of the mouse containing the major histocompatibility complex is shown in Figure 1. Despite all the information available regarding these molecules, the physiological function of H-2 and HL-A antigen is not known. A number of studies has shown that histocompatibility antigens are involved in cell-mediated lysis of xenoor allogeneic cells (2, 3). Recently it has been observed that murine histocompatibility antigens participate in the lysis of syngeneic chemically modified cells (4), virally infected cells (5) and neo-plastic cells (6, 7, 8). These data support the notion that histocompatibility antigens play an important role in the elimination of antigenically abnormal cells, and thus, they may form a highly complicated system of membrane proteins that serve as signals to distinguish “self” from “non-self”.

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References

  1. Gorer, P.A.: J. Pathol. Bacteriol. 47, 231–252 (1938)

    Article  Google Scholar 

  2. Lindahl, K.F., Bach, F.H.: Nature (Land.) 254, 607–609 (1975)

    Article  CAS  Google Scholar 

  3. Alter, B.J., Schendel, O.J., Bach, M.L., Bach, F.H., Klein, J., Stimpfling, J.H.: J. Exp. Med. 137, 1303–1309 (1973)

    CAS  Google Scholar 

  4. Shearer, G.M., Rehn, T.G., Garbarino, C.A.: J. Exp. Med. 141, 1348–1364 (1975)

    Article  PubMed  CAS  Google Scholar 

  5. Zinkernagel, R.M., Doherty, P.C.: J. Exp. Med. 141, 1427–1436 (1975)

    Article  PubMed  CAS  Google Scholar 

  6. Schrader, J.W., Cunningham, B.A., Edelman, G.M.: Proc. Nat. Acad. Sci. 72, 5066–5070 (1975)

    Article  PubMed  CAS  Google Scholar 

  7. Germain, R.N., Dorf, M.E., Benacerraf, B.: J. Exp. Med. 142, 1023–1028 (1975)

    Article  PubMed  CAS  Google Scholar 

  8. Schrader, J.W., Edelman, G.M.: J. Exp. Med. 143, 601–614 (1976)

    Article  PubMed  CAS  Google Scholar 

  9. Schwartz, B.D., Kato, K., Cullen, S.E., Nathenson, S.G.: Biochemistry 12, 2157–2164 (1973)

    Article  PubMed  CAS  Google Scholar 

  10. Zinkernagel, R.F., Doherty, P.C.: Nature (Land.) 251, 547–548 (1974)

    Article  CAS  Google Scholar 

  11. Strominger, J.L., Cresswell, P., Grey, H., Humphreys, R.E., Mann, D., McCune, J., Parham, P., Robb, R., Sanderson, A.R., Springer, T.A., Terhorst, C., Turner, M.J.: Transpl. Rev. 21, 126–143 (1974)

    CAS  Google Scholar 

  12. Peterson, P.A., Rask, L., Sege, K., Klareskog, L., Anundi,.H., Östberg, L.: Proc. Nat. Acad. Sci. 72, 1612–1616 (1975)

    Google Scholar 

  13. Grey, H.M., Kubo, R.T., Colon, S.M., Poulik, M.D., Cresswell, P., Springer, T., Turner, M., Strominger, J.L.: J. Exp. Med. 138, 1608–1612 (1973)

    Article  PubMed  CAS  Google Scholar 

  14. Nakamuro, K., Tanigaki, N., Pressman, D.: Proc. Nat. Acad. Sci. 70, 2863–2867 (1973)

    Article  PubMed  CAS  Google Scholar 

  15. Silver, J., Hood, L.: Nature (Land.) 249, 764–765 (1974)

    Article  CAS  Google Scholar 

  16. Peterson, P.A., Cunningham, B.A., Berggard, I., Edelman, G.M.: Proc. Nat. Acad. Sci. 72, 1697–1701 (1972)

    Article  Google Scholar 

  17. Cunningham, B.A., Wang, J.L., Berggârd, I., Peterson, P.A.: Biochemistry 12, 4811–4822 (1973)

    Article  PubMed  CAS  Google Scholar 

  18. Cunningham, B.A.: Federation Proc. 35, 1171–1176 (1976)

    CAS  Google Scholar 

  19. Henning, R., Milner, R.J., Reske, K., Cunningham, B.A., Edelman, G.M.: Proc. Nat. Acad. Sci. 73, 118–122 (1976)

    Article  CAS  Google Scholar 

  20. Cresswell, P., Dawson, J.R.: J. Immunol. 114, 523–525 (1975)

    PubMed  CAS  Google Scholar 

  21. Jacobs, J.W., Kemper, B., Niall, H.D. Habener, J.F., Potts, J.T., Jr.: Nature (Land.) 249, 155–157 (1974)

    Article  CAS  Google Scholar 

  22. Weiner, A.M., Platt, D., Weber, K.: J. Biol. Chem. 247, 3242–3251 (1972)

    PubMed  CAS  Google Scholar 

  23. Ewenstein, B.M., Freed, J.H., Mole, L.E., Nathenson, S.G.: Proc. Nat. Acad. Sci. 73, 915–918 (1976)

    Article  PubMed  CAS  Google Scholar 

  24. Bretschner, M.S. Nature (New Biol.) 231, 229–232 (1971)

    Article  Google Scholar 

  25. Segrest, J.P., Kahane, I., Jackson, R.L., Marchesi, V.T.: Arch. Biochem. Biophys, 155, 167–183 (1973)

    Article  PubMed  CAS  Google Scholar 

  26. Fu, S.M., Kunkel, H.G.: J. Exp. Med. 140, 895–903 (1974)

    Article  PubMed  CAS  Google Scholar 

  27. Klein, J., Schreffler, D.C.: Transpl. Rev. 6, 3–29 (1971)

    CAS  Google Scholar 

  28. Silver, J., Hood, L.: Proc. Nat. Acad. Sci. 73, 599–603 (1976)

    Article  PubMed  CAS  Google Scholar 

  29. Vitetta, E.S., Capra, J.D., Klapper, D.G., Klein, J., Uhr, J.W.: 73, 905–909 (1976)

    CAS  Google Scholar 

  30. Burnet, F.M.: Nature (Land.) 226, 123–126 (1970)

    Article  CAS  Google Scholar 

  31. Gaily, J.A., Edelman, G.M.: Ann. Rev. Genet. 6, 1–46 (1972)

    Article  Google Scholar 

  32. Terhorst, C., Parham, P., Mann,.D.L., Strominger, J.L.: Proc. Nat. Acad. Sci. 73, 910–914 (1976)

    Google Scholar 

  33. Cerottini, J.C., Brunner, K.T.: Advan. Immunol. 18, 67–132 (1974)

    Article  CAS  Google Scholar 

  34. Koszinowski, U., Ertl, H.: Nature (Land.) 255, 552–554 (1975)

    Article  CAS  Google Scholar 

  35. Cerny, J., Essex, M.: Nature (Lond.) 251, 742–744 (1974)

    Article  CAS  Google Scholar 

  36. Edelman, G.M., Yahara, I., Wang, J.L.: Proc. Nat. Acad. Sci. 70, 1442–1446 (1973)

    Article  PubMed  CAS  Google Scholar 

  37. Doherty, P.C., Zinkernagel, R.F.: Nature (Lund.) 256, 50–52 (1975)

    Article  CAS  Google Scholar 

  38. Edelman, G.M.: Science 192, 218–226 (1976)

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. R. Henning
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  2. J. W. Schrader
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  3. R. J. Milner
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  4. K. Reske
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  5. J. A. Ziffer
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  6. B. A. Cunningham
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  7. G. M. Edelman
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Editor information

Editors and Affiliations

  1. Basel Institute of Immunology, 487 Grenzacherstraße, 4058, Basel, Switzerland

    Fritz Melchers

  2. Institut für Genetik, Weyertal 1, 5000, Köln, Germany

    Klaus Rajewsky

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© 1976 Springer-Verlag Berlin · Heidelberg

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Henning, R. et al. (1976). Chemical Structure and Biological Activities of Murine Histocompatibility Antigens. In: Melchers, F., Rajewsky, K. (eds) The Immune System. Colloquium der Gesellschaft für Biologische Chemie, vol 27. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81083-1_18

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  • DOI: https://doi.org/10.1007/978-3-642-81083-1_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81085-5

  • Online ISBN: 978-3-642-81083-1

  • eBook Packages: Springer Book Archive

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