Advertisement

Whole-Body Hyperthermia. A Systemic Treatment for Disseminated Cancer

  • R. T. Pettigrew
  • C. M. Lugate
Part of the Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer book series (RECENTCANCER, volume 59)

Abstract

Regression of a disseminated tumour following inter-current infection and prolonged high fever was first reported by BUSCH over 100 years ago. In 1893 COLEY confirmed this observation and in a series of 38 patients with extensive cancer, who developed erysipelas and high fever, 12 had complete regression. COLEY then tried to reproduce this effect by injecting a mixture of toxins from the organisms responsible for erysipelas into patients with advanced malignancy, effecting some remarkable regressions. The use of toxins was unsatisfactory as a considerable time was taken to reach a maximum temperature of 40°C, and this temperature, in a toxic patient with disseminated disease, was difficult to maintain for long treatment intervals.

Keywords

Mycosis Fungoides Sweat Rate Serum Enzyme Activity Serum Bilirubin Concentration Body Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Allan, J.A., Armstrong, J.E., Roddie, I.C.: The regional distribution of emotional sweating in man. In: Proc. physiol. Soc. 1973, p. 37Google Scholar
  2. 2.
    Burger, F.J.: The effect of hyperthermia on serum enzymes activity. S. Afr. med. J. 44, 889–901 (1970)Google Scholar
  3. 3.
    Dickson, J.A., Ellis, H.A.: Stimulation of tumour cell differentiation by elevated temperature (4 2°C) in rats with transolated Yoshida tumours. Nature (Lond.) 248, 354–358 (1974)CrossRefGoogle Scholar
  4. 4.
    Findlay, J., Mcmanus, J., Ludgate, C.M., Pettigrew, R.T.: The effects of hyperthermia therapy on the liver. II. Morphological observations. J. clin. Path. (In press, 1975).Google Scholar
  5. 5.
    Giovanella, B.C. Lohman, W.A., Heidelberger, C.: Effect os elevated temperatures and drugs on the viability of L. 210 Leukaemia cells. Cancer Res. 30, 1623–1631 (1970)PubMedGoogle Scholar
  6. 6.
    Henderson, M.A., Pettigrew, R.T.: Induction of controlled hyperthermia in the treatment of cancer. Lancet (1971), 1275–1277Google Scholar
  7. 7.
    Johnston, H.J.: The action of short radiowaves on tissues - A comparison of the thermal sensitivities of transplantable tumours in vivo and in vitro. Amer. J. Cancer 38, 533–550 (1970)Google Scholar
  8. 8.
    Karle, H.: Destruction of red blood cells during experimental fever. Acta med. scand. 186, 349–359 (1969)PubMedCrossRefGoogle Scholar
  9. 9.
    Mckenzie, A.: Personal communication, 1975Google Scholar
  10. 10.
    Stevenson, D.E.: Chanoes caused by anaesthesia in the blood electrolytes of the dog. Brit. J. Anaesth. 32, 353–363 (1960)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1977

Authors and Affiliations

  • R. T. Pettigrew
  • C. M. Lugate

There are no affiliations available

Personalised recommendations