Whole-Body Hyperthermia. A Systemic Treatment for Disseminated Cancer
Regression of a disseminated tumour following inter-current infection and prolonged high fever was first reported by BUSCH over 100 years ago. In 1893 COLEY confirmed this observation and in a series of 38 patients with extensive cancer, who developed erysipelas and high fever, 12 had complete regression. COLEY then tried to reproduce this effect by injecting a mixture of toxins from the organisms responsible for erysipelas into patients with advanced malignancy, effecting some remarkable regressions. The use of toxins was unsatisfactory as a considerable time was taken to reach a maximum temperature of 40°C, and this temperature, in a toxic patient with disseminated disease, was difficult to maintain for long treatment intervals.
KeywordsAdenocarcinoma Respiration Fractionation Melphalan Gall
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