Skip to main content
SpringerLink
Log in
Book cover

Selective Heat Sensitivity of Cancer Cells pp 7–35Cite as

Biochemical Aspects of Heat Sensitivity of Tumour Cells

  • Chapter

Abstract

As mentioned in the Introduction, and as shall be taken up in the following chapter, several lines of evidence have indicated, starting from the first observation by BUSCH (17) over a century ago, that temperatures above the physiologic value might have destructive effects on cancer. As shall be described in the next chapter, in vivo therapeutic applications require the solution of a number of problems: validity and verification, in every case, of the assumption that hyperthermia will be beneficial, i.e., that tumor cells will be more temperature-sensitive than the surrounding normal ones; decisions as to the level of hyperthermia that must be reached, as well as its duration, and the rate at which the final level is to be attained; possible use of substances that act as potentiators of hyperthermia, or of procedures which, associated with the high temperature, result in a more selective and/or extensive damage of the tumor, or that limit the danger of metastatic diffusion; evaluation of the immune status of the patient, in view of the possibility (which shall be discussed in this chapter and elsewhere in this volume that immunity plays a role in tumor regression and prevention of metastasis; technical difficulties in maintaining, with minimal oscillations and for the time required, a given high temperature in the whole tumor mass, controlling it constantly and avoiding the appearance in the patient of adverse effects, such as heat stroke, fluid and/or electrolyte loss, shock, acidosis, renal failure, local edema, etc.; subsequent treatment of the patient in order to avoid not only recurrences and/or metastases but also, as has sometimes been the case in large tumor masses undergoing rapid necrosis (19), late complications due to resorption of heat-damaged tumor tissues.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Allison, A.C., Paton, G.R.: Chromosome damage in human diploid cells following activation of lysosomal enzymes. Nature (Lond.) 207, 1170 (1965)

    CAS  Google Scholar 

  2. Amalric, F., Simard, R., Zalta, J.P.: Effect de la temperature supra-optimale sur les ribonucleoproteines et le RNA nucleolaire; II. Etude biochimique. Exp. Cell Res. 55, 370 (1969)

    PubMed  CAS  Google Scholar 

  3. Arca, M., Calvori, C., Frontali, L., Tecce, G.: The enzymic synthesis of aminoacyl derivatives of soluble ribonucleic acid from Bacillus stearothermophilus. Biochim. biophys. Acta 87, 440 (1964)

    CAS  Google Scholar 

  4. von Ardenne, M.: Betrachtungen und Messungen zur selektiven chemischen Sensibilisierung der Krebszellen gegen Wärme. In: Theoretische und experimentelle Grundlagen der Krebs-Mehrschritt Therapie. Von Ardenne, M. (ed.) Berlin: VEB Verlag Volk und Gesundheit, p. 298

    Google Scholar 

  5. von Ardenne, M., Krüger, W.: Über die Auffindung eines Bereiches hoher Selektivität zwischen Krebszellen und gesunden Zellen bei der Krebstherapie mit Extremhyperthermie. Naturwissenschaften 53, 436 (1966)

    Google Scholar 

  6. von Ardenne, M., Reitnauer, P.G., Rieger, F.: Zur Erkundung therapeutischer Angriffspunkte im intermediären Stoffwechsel der Krebszelle. In: Theoretische und experimentelle Grundlagen der Krebs-Mehrschritt-Therapie. Von Ardenne, M. (ed.) Berlin: VEB Verlag Volk und Gesundheit, 1967, p. 286

    Google Scholar 

  7. Auersperg, N.: Differential heat sensitivity of cells in tissue culture, Nature (Lond.) 209, 415 (1966)

    CAS  Google Scholar 

  8. Bacchetti, S., Cassandro, M., Mauro, F.: Radiosensitivity in relation to the cell cycle and recovery from X-ray sublethal damage in diploid yeast. Exp. Cell Res. 46, 292 (1967)

    PubMed  CAS  Google Scholar 

  9. Bender, E., Schramm, T.: Untersuchungen zur Thermosensibilität von Tumor und Normalzellen in Vitro. Acta biol. med. germ. 17, 527 (1966)

    PubMed  CAS  Google Scholar 

  10. Ben-Hur, E., Bronk, B.V., Elkind, M.M.: Thermally enhanced radiosensitivity of cultures Chinese hamster cells. Natur (New Biol.) 238, 209 (1972)

    CAS  Google Scholar 

  11. Ben-Hur, E., Elkind, M.M., Bronk, B.V.: Thermally enhanced radioresponse of cultured Chinese hamster cells. Inhibition or repair of sub-lethal damage and enhancement of lethal damage. Radiat. Res. 58, 38 (1974)

    PubMed  CAS  Google Scholar 

  12. Boedtker, H.: Configurational proteries of Tobacco Mosaic Virus ribonucleic acid. J. molec. Biol. 2, 171 (1960)

    CAS  Google Scholar 

  13. Bogdanova, E.S., Gavrilova, L.P., Dvorkin, G.A., Kiselev, N.A., Spirin, A.S.: Studies on the macromolecular structure of high polymer (ribosomal) ribonucleic acid from Escherichia coli. Biokhimiya 27, 387 (1962)

    CAS  Google Scholar 

  14. Brandts, J.F.: Heat effects on proteins and enzymes. In: Thermo- biology. Rose, A.H. (ed.) London: Academic Press, D. 24, 1967

    Google Scholar 

  15. Bridges, B.A., Ashwood-Smith, M.J., Munson, R.J.: Correlation of bacterial sensitivites to ionizing radiation and mild heating. J. gen. Microbiol. 58, 115 (1969)

    PubMed  CAS  Google Scholar 

  16. Bucciante, L.: Ulteriori ricerche sulla velocitä della mitosi nelle cellule coltivate in vitro in funzione della temperatura. Arch. exp. Zellforsch. 5., 1 (1928)

    Google Scholar 

  17. Busch, W.: Über den Einfluss, welchen heftigere Erysipeln zuweilen auf organisierte Neubildungen ausüben: Verhandl. Naturhist. Preuss. Rhein. Westphal. 23, 28 (1866)

    Google Scholar 

  18. Byfield, J.E., Scherbaum, K,: Suppression of RNA and protein accumulation by temperature shifts in a heat-synchronized protozoa. Life Sci. 5, 2263 (1966)

    PubMed  CAS  Google Scholar 

  19. Cavaliere, R., Ciocatto, E.C., Giovanella, B.C., Heidelberger, C., Johnson, R.O., Margottini, M., Mondovi, B., Moricca, G., Rossi- Fanelli, A.: Selective heat sensitivity of cancer cells. Cancer (Philad.) 20, 1351 (1967)

    CAS  Google Scholar 

  20. Chang, S.B., Matson, R.S.: Membrane stability (thermal) and nature of fatty acids in yeast cells. Biochem. biophys. Res. Comm. 46, 1529 (1972)

    PubMed  CAS  Google Scholar 

  21. Chapman, D.: The effect of heat on membranes and membrane con-stituent. In: Thermobiology. Rose, A.H. (ed.), London: Academic Press, 1967, p. 122

    Google Scholar 

  22. Chapman, D. Williams, R.M., Ladbrooke, B.D.; Physical studies of some phospholipids. VI. Thermotropic and lyotropic mesomorphism of some 1,2- diacylphosphatidylcholines (lecithins). Chem Phys. Lipids 1, 445 (1967)

    CAS  Google Scholar 

  23. Check, J.H., Childs, T.C., Brady, L.W., Derasse, A.R., Fuscaldo, K.E.: Protection against spontaneous mouse mammary adenocarcinoma by inoculation of heat-treated syngeneic mammary tumor cells. Int. J. Cancer 7, 403 (1971)

    PubMed  CAS  Google Scholar 

  24. Clarke, K.U.: Insects and temperature. In: Thermobiology. Rose, A.H. (ed.), London: Academic Press, 1967, p. 293

    Google Scholar 

  25. Clowes, G.H.A.: A study of the influence exerted by a variety of physical and chemical forces on the virulence of carcinoma in mice, and of the conditions under which immunity against cancer may be experimentally induced in these animals. Brit. med. J. 2, 1548 (1906)

    Google Scholar 

  26. Collins, P., Lacy, D.: Studies on the structure and function of the mammalian testis. II. Cytological and histochemical observation on the testis of the rat after a single exposure to heat applied for different lengths of time. Proc. roy. Soc. B 172, 17 (1969)

    CAS  Google Scholar 

  27. Cullen, J., Phillips, M.C., Shipley, G.G.: The effects of temperature on the composition and physical properties of the lipids of Pseudomonas fluorescens. Biochem. J. 125, 733 (1 971)

    Google Scholar 

  28. Cuzin, F., Vogt, M., Dieckmann, M., Berg, P.: Induction of virus multiplication in 3T3 cells tranformed by a thermosensitive mutant of polyoma virus. II. Formation of oligomeric polyoma DNA molecules. J. molec. Biol. 47, 317 (1970)

    PubMed  CAS  Google Scholar 

  29. Davidson, J.N.: The Biochemistry of the Nucleic Acids. London: Methuen and Co., 1969

    Google Scholar 

  30. van Deenen, L.L.M.: Membrane lipids. In: Regulatory Functions of Biological Membranes. Järnefelt, J., (ed.), Amsterdam: J., (ed.), 1968, Vol. XI, p. 72

    Google Scholar 

  31. Dewey, W.C., Furman, S.C., Miller, H.H.: Comparison of. lethality and chromosomal damage induced by X-rays in synchronized Chinese hamster cells in vitro. Radiat. Res.. 43, 561 (1970)

    PubMed  CAS  Google Scholar 

  32. Dewey, W.C., Westra, A., Miller, H.H., Nagasawa, H.: Heat- induced lethality and chromosomal damage in synchronized Chinese hamster cells treated with 5-bromodeoxyuridine. Int. J. Radiat. Biol 20, 505 (1971)

    CAS  Google Scholar 

  33. Dickson, J.A., Ellis, H.A.: Stimulation of tumour cell dis-semination by raised temperature (42°C) in rats with trans-planted Yoshida tumours. Nature (Lond.) 248, 354 (1974)

    CAS  Google Scholar 

  34. Dickson, J.A., Muckle, D.S.: Total body hyperthermia versus primary tumor hyperthermia in the treatment of the rabbit VX-2 carcinoma. Cancer Res. 32, 1916 (1972)

    PubMed  CAS  Google Scholar 

  35. Dickson, J.A., Shah, D.M.: The effect of hyperthermia (42°C) on the biochemistry and growth of a malignant cell line. Europ. J. Cancer, 8, 561 (1972)

    CAS  Google Scholar 

  36. Dickson, J.A., Suzangar, M.: In vitro sensitivity screening system for human cancers to drugs and hyperthermia. Brit. J. Cancer 28, 81 (1973)

    PubMed  CAS  Google Scholar 

  37. Dickson, J.A., Suzangar, M.: In vitro-in vivo studies on the susceptibility of the solid Yoshida sarcoma to drugs and hyperthermia (42°C). Cancer Res. 34, 1263 (1974)

    PubMed  CAS  Google Scholar 

  38. Dijoseph, C.G., Kaji, A.: The thermosensitive lesion in the replication of the drug resistance factor, Rts1. Proc. nat. Acad. Sci. (Wash.) 71, 2515 (1974)

    CAS  Google Scholar 

  39. Eidlic, L., Miedhardt, F.C: The thermosensitive critical event of the viral cycle. J. Bact. 89, 706 (1965)

    PubMed  CAS  Google Scholar 

  40. Eigner, J., Boedtker, H., Michaels, G.: The thermal degradation of nucleic acids. Biochim. biophys. Acta 51, 165 (1961)

    PubMed  CAS  Google Scholar 

  41. Emmelot, P., Benedetti, E.L.: On the possible involvement of the plasma membranes in the carcinogenic process. In: Carcinogenesis: a Broad Critique, Baltimore: Williams and Wilkins, p. 471

    Google Scholar 

  42. Esfahani, M., Barnes, E.M., Wakil, S.J.: Control of fatty acid composition in phospholipids of Escherichia coli: response to fatty acid supplements in a fatty acid auxotroph. Proc. nat. Acad. Sci. (Wash.) 64, 1057 (1969)

    CAS  Google Scholar 

  43. Esser, A.F., Souza, K.A.: Correlation between thermal death and membrane fluidity in Bacillus stearothermophilus. Proc. Nat. Acad. Sci. (Wash.) 71, 4111 (1974)

    CAS  Google Scholar 

  44. Everson, D.P., Prescott, D.M.: Disruption of DNA synthesis in Euplotes by heat shock. Exp. Cell Res. 613, 245 (1970)

    Google Scholar 

  45. Evreinova, T.N., Davydova, I.M., Sukover, A.P., Goryunova, S.V.: Nucleic acids of thermophilic blue-green algae Mastigocladus laminosus. Dokl. Akad. Nauk. U.S.S.R. 137, 213, (1961)

    CAS  Google Scholar 

  46. Farrel, J., Rose, A.H.: Temperature effects on microorganisms. In: Thermobiology. Rose, A.H. (ed.), London: Academic Press, 1967, p. 146

    Google Scholar 

  47. Fenner, F., Holmes, I.H., Joklik, W.K., Woodroofe, G.M.: Reactivation of heat-inactivated pox viruses: a general phenomenon which includes the fibroma-mixoma virus transformation of Berry and Dedrick. Nature (Lond.) 183, 1340 (1959)

    CAS  Google Scholar 

  48. Fenyo, E.M., Biberfeld, P., Klein, E.: Studies on the relations between virus release and cellular immunosensitivity on Moloney lymphomas. J. nat. Cancer Inst. 42, 837 (1969)

    PubMed  CAS  Google Scholar 

  49. Fresco, J.R., Adams, A., Ascione, R., Henley, D., Lindahl, T.: Tertiary structure in transfer ribonucleic acids. Cold Spr. Harb. Symp. quant. Biol. 31, 527 (1966)

    CAS  Google Scholar 

  50. Friedgood, H.B.: On the thermal death point of sarcoma and normal mononuclear cells (Walker rat tumor Nr. 1). Arch. exp. Zell- forsch. 7, 243 (1928)

    Google Scholar 

  51. Friedkin, M.: Enzymatic aspects of folic acid. Ann. Rev. Biochem. 32, 185 (1963)

    PubMed  CAS  Google Scholar 

  52. Friedman, S.M., Weinstein, I.B.: Protein synthesis in a sub-cellular system from Bacillus stearothermophilus. Biochim. biophys. Acta 114, 593 (1966)

    PubMed  CAS  Google Scholar 

  53. Fulco, A.J.; The biosynthesis of unsaturated fatty acids by bacilli, IV. Temperature-mediated control mechanism. J. biol. Chem. 247, 3511 (1972)

    PubMed  CAS  Google Scholar 

  54. Gallant, J., Stapleton, R.: Properties of a temperature-sensitive regulatory system. Proc. nat. Acad. Sci. (Wash.) 50, 348 (1963)

    CAS  Google Scholar 

  55. Gericke, D.: Studies on the thermosensitivity of experimental tumors in small animals. Abstr. Tenth Internat. Cancer Congr., p. 572, Houston (1970)

    Google Scholar 

  56. Gericke, D., Chandra, P., Orii, H., Wacker, A.: In vitro thermo- sensibility of experimental tumors in small animals. Naturwissen- schaften 3, 135 (1971)

    Google Scholar 

  57. Ginoza, W., Guild, W.R.: On the inactivation of transforming DNA by temperature below the melting point. Proc. nat. Acad. Sci. (Wash.) 47, 633 (1961)

    CAS  Google Scholar 

  58. Giovanella, B.C., Lohman, W.A., Heidelberger, C.: Effects of elevated temperatures and drugs on the viability of L1210 leukemia cells. Cancer Res., 30, 1623 (1970)

    PubMed  CAS  Google Scholar 

  59. Giovanella, B.C., Morgan, A.C., Stehlin, J.S., Williams, L.J.: Selective lethal effect of supranormal temperatures on mouse sarcoma cells. Cancer Res. 33, 2568 (1973)

    PubMed  CAS  Google Scholar 

  60. Goebel, W.: Studies on extrachromosomal DNA elements. Euroo. J. Biochem. 115, 31 1 (1970)

    Google Scholar 

  61. Green, S., Zamenhof, S.: Studies on deuurination of DNA by heat. J. molec. Biol. 4, 123 (1962)

    Google Scholar 

  62. Haaland, M.: Contributions to the study of the development of sarcomas under experimental conditions. A.R. imp. Cancer Res. Fd. p. 175 (1908)

    Google Scholar 

  63. Hahn, G.M.: Metabolic aspects of the role of hyperthermia in mammalian cell inactivation and their possible relevance to cancer treatment. Cancer Res., 34, 3117 (1974)

    PubMed  CAS  Google Scholar 

  64. Hall, R.H.: The modified Nucleosides in Nucleic Acids. New York: Columbia University Press, 1971

    Google Scholar 

  65. Hanafusa, T., Hanafusa,.H., Kamahora, J.: Transformation of Ectromelia into Vaccinia virus in tissue culture. Virology 8, 525 (1959)

    PubMed  CAS  Google Scholar 

  66. Harris, M.: Criteria of viability in heat-treated cells. Exp. Cell Res. 44, 658 (1966)

    PubMed  CAS  Google Scholar 

  67. Harris, M.: Temperature-resistant variants in clonal populations of pig kidney. Exp. Cell Res. 46, 301 (1967)

    PubMed  CAS  Google Scholar 

  68. Harris, M.: Maturation rates at different ploidy level. J. cell. Physiol. 78, 177 (1971)

    PubMed  CAS  Google Scholar 

  69. Harris, J.R., Whitmore, G.F: Chinese hamster cells exhibiting a temperature dependent alteration in purine transport. J. cell. Physiol. 83, 43 (1974)

    PubMed  CAS  Google Scholar 

  70. Heine, U., Sverak, L., Kondratick, J., Bonar, R.A.: The behavior of HeLa-S3 cells under the influence of supranormal temperatures. J. Ultrastruct. Res. 34, 375 (1971)

    PubMed  CAS  Google Scholar 

  71. Hilbers, C.W., Shulman, R.G., Yamane, T., Steitz, J.A.: High resolution proton NMR study of an isolated fragment of R17 bacteriophage in RNA. Nature (Lond.) 248, 225 (1974)

    CAS  Google Scholar 

  72. Hinz, H.J., Sturtevant, J.M.: Calorimetric investigation of the influence of cholesterol on the transmission properties of bilayers formed from synthetic L-CX -lecithins in aqueous susoension. J. biol. Chem. 247, 3697 (1972)

    PubMed  CAS  Google Scholar 

  73. Horiuchi, T., Novick, A.: A thermolabile repression system. Cold Spr. Harb. Symp. quant. Biol. 26., 247 ( 1961

    Google Scholar 

  74. Huang, L., Lorch, S.K., Smith, G.G., Huang, A.: Control of membrane lipid fluidity in Acholeplasma laidlawii. FEBS Lett. 43, 1 (1974)

    PubMed  CAS  Google Scholar 

  75. Jackson, W.M., Kostyla, J., Nordin, J.H., Brandts, J.F.: Calori-metric study of protein transitions in human erythrocyte ghosts. Biochemistry 12, 3662 (1973)

    PubMed  CAS  Google Scholar 

  76. Jares, J.J., Warren, S.L.: Physiological effects of radiation. I. A study of the in vitro effect of high fever temperatures upon certain experimental animal tumors. Amer. J. Roentgenol. 41, 685 (1939)

    Google Scholar 

  77. Jensen, C.O.: Experimentelle Untersuchungen über Krebs bei Mäusen; Zbl. Bakt. 34, 28 (1903)

    Google Scholar 

  78. Johnson, H.J.: The action of short radio waves on tissues. III. A comparison of the thermal sensitivities of transplantable tumors in vivo and in vitro. Amer. J. Cancer 38, 533 (1940)

    Google Scholar 

  79. Johnson, F.H., Eyring, H., Palissar, M.J.: The Kinetic Basis of Molecular Biology. New York: J. Wiley and Sons, 1954

    Google Scholar 

  80. Joklik, W.K., Abel, P., Holmes, I.H.: Reactivation of pox viruses by an non-genetic mechanism. Nature (Lond.) 186, 992 (1960)

    CAS  Google Scholar 

  81. Kaback, H.R.: The role of the phosphoenolpyruvate-phosphotrans- ferase system in the transport of sugars by isolated membrane preparations of Escherichia coli. J. biol. Chem. 243, 3711 (1968)

    PubMed  CAS  Google Scholar 

  82. Kachani, Z.F.C., Sabin, A.B.: Reproductive capacity and viability at higher temperatures of various transformed hamster cell lines. J. nat. Cancer Inst. 43, 469 (1969)

    PubMed  CAS  Google Scholar 

  83. Kelly, L.E.: Temperature-sensitive mutations affecting the regenerative sodium channel in Drosophila melanogaster. Nature (Lond.) 218, 166 (1974)

    Google Scholar 

  84. Koffler, H., Gale, G.O.: The relative thermostability of cytoplasmic proteins from thermophili bacteria. Arch. Biochem. 617, 249 (1957)

    Google Scholar 

  85. de Kruyff, B., van Duck, P.W.M., Goldbach, R.W., Demel, R.A., van Deenen, L.L.M.: Influence of fatty acid and sterol composition on the lipid phase transition and activity of membrane-bound enzymes in Acholeplasma laidlawii. Biochim. biophys. Acta 330,

    Google Scholar 

  86. de Kruyff, B., De Greef, W.J., Vaneyk, R.V.W., Demel, R.A., van Deenen, L.L.M.: The effect of different fatty acid and sterol composition on the erythritol flux through the cell membrane of Acholeplasma laidlawii. Biochim. biophys. Acta 298, 479 (1973)

    PubMed  Google Scholar 

  87. Ladbrooke, B.D., Williams, R.M., Chapman, D.: Studies on lecithin- cholesterol-water interactions by differential scanning calorimetry and X-ray diffraction. Biochim. biophys. Acta 150, 333 (1968)

    PubMed  CAS  Google Scholar 

  88. Lambert, R.A.: Demonstration of the greater susceptibility to heat of sarcoma cells as compared with actively proliferating connective-tissue cells. J. Amer. med. Ass. 59, 2147 (1912)

    Google Scholar 

  89. Levine, E.M., Robbins, E.B.: Differential temperature sensitivity of normal and cancer cells in culture. J. cell. Physiol. 76, 373 (1970)

    PubMed  CAS  Google Scholar 

  90. Lewin, S., Pepper, D.S.: Variation of the melting temperature of calf-thymus DNA with pH and type of buffer. Arch. Biochem. 109, 192 (1965)

    PubMed  CAS  Google Scholar 

  91. Lin, P.S., Wallach, D.F.H., Tsai, S.: Temperature-induced variations in the surface topology of cultured lymphocytes are revealed by scanning electron microscopy. Proc. nat. Acad. Sci. (Wash.) 70, 2492 (1973)

    CAS  Google Scholar 

  92. Loeb, L.: Über Transplantation von Tumoren. Virchows Arch. path. Anat. 172, 345 (1903)

    Google Scholar 

  93. Love, R., Soriano, R.Z., Walsh, R.J.: Effect of hyperthermia on normal and neoplastic cells in vitro. Cancer Res. 30, 1525 (1 970)

    Google Scholar 

  94. Lutton, E.S.: Thermal properties and crystal state. In: Fatty Acids. Markley, K.S. (ed.) New York: Interscience Publ. 1967, Pt. 4, p. 2583

    Google Scholar 

  95. Luzzati, V., Husson, F.: The structure of the liquid-crystalline phases of lipid-water systems. J. Cell Biol. 12, 207 (1 962)

    Google Scholar 

  96. Lwoff, A.: The thermosensitive critical event of the viral cycle. Cold Spr. Harb. Symp. quant.. Biol. 27, 159 (1 962)

    Google Scholar 

  97. Lyons, J.M.: Phase transitions and control of cellular metabolism at low temperatures. Cryobiology 9, 341 (1 972)

    Google Scholar 

  98. Mangiantini, M.T., Tecce, G., Toschi, G.: Molecular properties and thermal stability of ribonucleic acid in a thermophilic micro-organism. Suppl. Nuovo Cimento 25, 45 (1962)

    CAS  Google Scholar 

  99. Manning, G.B., Campell, L.L.: Thermostable CX-amylase of Bacillus Stearothermophilus. J. biol Chem. 236, 2952 (1961)

    PubMed  CAS  Google Scholar 

  100. Marmur, J.: Thermal denaturation of deoxyribosenucleic acid isolated from a thermophile. Biochim. biophys. Acta 313, 34 2 (1960)

    Google Scholar 

  101. Marmur, J., Doty, P.: Heterogeneity in deoxyribonucleic acids. I. Dependence on composition of the configurational stability of deoxyribonucleic acids. Nature (Lond.) 183, 1427 (1959)

    Google Scholar 

  102. Marr, A.G., Ingraham, J.L.: Effect of temperature on the com-position of fatty acids in Escherichia coli. J. Bact. 84, 1260 (1962)

    PubMed  CAS  Google Scholar 

  103. Marx, J.L.: Biochemistry of cancer cells: focus on the cell surface. Science 183, 1 279 (1974)

    Google Scholar 

  104. Martin, R.J., Schloerb, P.R.: Induction of mitotic synchrony by intermittent hyperthermia in the Walker 256 rat carcinoma. Cancer Res. 24, 1997 (1964)

    Google Scholar 

  105. Mcburney, M.W., Whitmore, G.F.: Selection for temperature-sensitive mutants of diploid and tetraploid mammalian cells. J. cell. Physiol. 83, 69 (1974)

    PubMed  CAS  Google Scholar 

  106. Mccormick, W., Penman, S.: Regulation of protein syntheis in HeLa cells: translation at elevated temperatures. J. molec. Biol. 39, 315 (1969)

    PubMed  CAS  Google Scholar 

  107. Meiss, H.K., Basilico, C.: Temperature sensitive mutants of BHK 21 cells. Nature (New Biol.) 239, 66 (1972)

    CAS  Google Scholar 

  108. Mondovi, B., Finazzi-Agro, A., Rotilio, G., Strom, R., Moricca, G., Rossi-Fanelli, A.: The biochemical mechanism of selective heat sensitivity of cancer cells. II. Studies on nucleic acids and protein synthesis. Europ. J. Cancer 5, 1 37 (1 969)

    Google Scholar 

  109. Mondovi, B., Scioscia Santoro, A., Strom, R., Faiola, R., Rossi- Fanelli, A.: Increased immunogenicity of Ehrlich ascites cells after heat treatment. Cancer (Philad.) 30, 885 (1972)

    CAS  Google Scholar 

  110. Mondovi, B., Strom, R., Finazzi-Agro, A., Caiafa, P., de Sole, P., Bozzi, A., Rotilio, G., Rossi-Fanelli, A.: Effects of polyenic antibiotics on Ehrlich ascites and Novikoff hepatoma cells. Cancer Res. 31, 505 (1971)

    PubMed  CAS  Google Scholar 

  111. Mondovi, B., Strom, R., Rotilio, G., Finazzi-Agro, A., Cavaliere, R., Rossi-Fanelli, A.: The biochemical mechanism of selective heat sensitivity of cancer cells. I. Studies on cellular respiration. Europ. J. Cancer 5, 1 29 (1 969)

    Google Scholar 

  112. Muckle, D.S., Dickson, J.A.: The selective inhibition effect of hyperthermia on the metabolism on growth of malignant cells. Brit. J. Cancer 25, 771 (1971)

    PubMed  CAS  Google Scholar 

  113. Muckle, D.S., Dickson, J.A.: Hyperthermia (42°C) as an adjuvant to radiotherapy and chemotherapy in the treatment of the allogeneic VX-2 carcinoma in the rabbit. Brit. J. Cancer 27, 307 (1973)

    PubMed  CAS  Google Scholar 

  114. Muller, H.J.: The measurement of gene mutation rate in Drosophila, its high variability and its dependence upon temperature. Genetics 13, 279 (1928)

    PubMed  CAS  Google Scholar 

  115. Nass, M.M.K.: Temperature-dependent formation of dimers and oligomers of mitochondrial DNA in cells transformed by an thermo- sensitive mutant of Rous sarcoma virus. Proc. nat. Acad. Sci. (Wash.) 70, 3739 (1973)

    CAS  Google Scholar 

  116. Ormerod, M.G., Stevens, U.: The rejoining of X-ray-induced strand breaks in the DNA of a murine lymphoma cell (L5178Y). Biochim. biophys. Acta 232, 72 (1971)

    PubMed  CAS  Google Scholar 

  117. Ossovski, L., Sachs, L.: Temperature sensitivity of polyoma virus, induction of cellular DNA synthesis, and multiplication of trans-formed cells at high temperature. Proc. nat. Acad. Sci. (Wash.) 58, 1938 (1967)

    CAS  Google Scholar 

  118. Overath, P., Schairer, H.U., Stoffel, W.; Correlation of in vivo and in vitro phase transitions of membrane lipids in Escherichia coli. Proc. nat. Acad. Sci (Wash.) 67, 606 (1970)

    CAS  Google Scholar 

  119. Overgaard, K., Overgaard, J.: Investigation on the possibility of a thermic tumor therapy. I. Short wave treatment of a transplanted isologous mouse mammary carcinoma. Cancer (Philad.) 8, 65, (1972a)

    CAS  Google Scholar 

  120. Overgaard, K., Overgaard, J.: Investigations on the possibility of a thermic tumor therapy. II. Action of combined heat-Roentgen treatment on a transplanted mouse mammary carcinoma. Europ. J. Cancer 8, 572 (1972b)

    Google Scholar 

  121. Palzer, R.J., Heidelberger, C.: Studies on the quantitative biology of hyperthermic killing of HeLa cells. Cancer Res. 33, 415 (1973a)

    PubMed  CAS  Google Scholar 

  122. Palzer, R.J., Heidelberger, C.: Influence of drugs and synchrony on the hyperthermic killing of HeLa cells. Cancer Res. 313, 4 22 (1973b)

    Google Scholar 

  123. Petrakis, N.L., Lieberman, E.: The thermal susceptibility of leucocytes from normal and leukemic subjects. Clin. Res. Proc. 1, 53 (1956)

    Google Scholar 

  124. Peypoux, F., Michel, G.: Etude des phospholipides d’une souche sauvage et d’une souche mutante thermosensible d1 Escherichia coli. Biochim. biophys. Acta 218, 453 (1970)

    PubMed  CAS  Google Scholar 

  125. Phillips, M.C.: Physical state of phospholipids and cholesterol in monolayers, bilayers and membranes. In: Progress in Surface and Membrane Science. Danielli, J.F., Rosenberg, M.D., Cadenhead, D.A. ( eds.). New York: D.A. (eds.). 1972, Vol. V, p. 139

    Google Scholar 

  126. Plagemann, P.G.W.: Nucleoside transport by Novikoff rat hepatoma cells. Specificity and mechanism of transport. Reactions and relationship to nucleoside incorporation into nucleic acids. Biochim. biophys. Acta. 233, 688 (1971)

    PubMed  CAS  Google Scholar 

  127. Plagemann, P.G.W., Erbe, J.: Thymidine transport by cultured Novikoff hepatoma cells and uptake by simple diffusion and relationship to incorporation into deoxyribonucleic acid. J. Cell Biol. 55, 161 (1972)

    PubMed  CAS  Google Scholar 

  128. Privalov, P. L.:• Thermal investigation of biopolymer solutions and scanning microcalorimetry. FEBS Lett. 40, S 140 (1974)

    Google Scholar 

  129. Reeves, O.R.: Mechanism of acquired resistence to acute heat shock in cultured mammalian cells. J. cell. Phvsiol. 19, 157 (1972)

    Google Scholar 

  130. Renger, H.C., Basilico, C.: Mutation causing temperature-sensitive expression of cell transformation by tumor virus. Proc. nat. Acad. Sci. (Wash.) 69, 109 (1972)

    CAS  Google Scholar 

  131. Renner, E.D., Plagemann, P.G.W., Bernlohr, R.W.; Permeation of glucose by simple and facilitated diffusion by Novikoff rat hepatoma cells in suspension culture and its relationship to glucose metabolism. J. biol. Chem. 247, 5765 (1972)

    PubMed  CAS  Google Scholar 

  132. Rieber, M., Bacolao, J.: Selective enhancement of cytoplasmic protein species and continued histone synthesis during inhibition of DNA synthesis in temperature-sensitive Chinese hamster cells. Cancer Res. 34, 3083 (1974)

    PubMed  CAS  Google Scholar 

  133. Robinson, J.E., Wizenberg, M.J., Mccready, W.A.; Combined hyperthermia and radiation suggest an alternative to heavy particle therapy for reduced oxygen enhacement ratios. Nature (Lond.) 251, 521 (1974)

    CAS  Google Scholar 

  134. Robinson, J.E., Wizenberg, M.J., Mccready, W.A., Scheltema, J.: Thermally enhanced radiocurability of mammary tumor in C3H Mice. Proc. IV Intern. Biophys. Congress, Vol. 1, comm. EIII d 3 /11, p. 289, Moscow (1972)

    Google Scholar 

  135. Rohdenburg, G.L., Prime, F.: Effect of combined radiation and heat on neoplasms. Arch. Surg. (Chicago) 2, 116 (1921)

    Google Scholar 

  136. Rosenthal, L.J. Jandolo, J.J.: Thermally induced intracellular alterations of ribosomal ribonucleic acid. J. Bact. 103, 833 (1970)

    PubMed  CAS  Google Scholar 

  137. Sapozinsk, M.D., Deschner, E.E., Hahn, E.W.: Induction of mitotic synchrony by intermittent hyperthermia in Ehrlich carcinoma in vivo. Nature (Lond.) 244, 299 (1973)

    Google Scholar 

  138. Saunders, F.G., Campell, L.L.: Ribonucleic acid and ribosomes of Bacillus stearothermophilus. J. Bact. 91, 332 (1966)

    PubMed  CAS  Google Scholar 

  139. Schenberg-Frascino, A.: Lethal and mutagenic effects of elevated temperature on haploid yeast. II. Recovery from thermolesions. Molec. gen. Genet. 117, 239 (1972)

    CAS  Google Scholar 

  140. Schenberg-Frascino, A., Moustacchi, E.: Lethal and mutagenic effects of elevated temperature on haploid yeast. II. Recovery from thermolesions. Molec. gen. Genet. 115, 243 (1972)

    CAS  Google Scholar 

  141. Schreck, R.: Prednisolone-sensitivity and cytology of viable lymphocytes as tests for chronic lymphocytic leukemia. J. nat. Cancer Inst. 33, 837 (1964)

    Google Scholar 

  142. Schreck, R.: Effect of heat and dimethyl sulfoxide on normal and leukemic lymphocytes. Lancet (1965) ii, 1020

    Google Scholar 

  143. Schrek, R.: Sensitivity of normal and leukemic lymphocytes and leukemia myeloblasts to heat. J. nat. Cancer Inst. 31, 649 (1966)

    Google Scholar 

  144. Schwencke, J. Magana-Schwencke, N.: Temperature effects on the proline transport system of Saccaromyces chevalieri. Biochim. biophys. Acta 241, 513 (1971)

    PubMed  CAS  Google Scholar 

  145. Selawry, O.S., Goldstein, M.M., Mccormick, T.: Hyperthermia in tissue-cultured cells of malignant origin. Cancer Res. 17, 785 (1957)

    PubMed  CAS  Google Scholar 

  146. Sherman, F.: A study of the effects of elevated temperatures on the growth and inheritance of Saccaromyces cervisiae. Ph. D. thesis, University of California, UCRL - 8573 (1958)

    Google Scholar 

  147. Simard, R.: Une fonction cellulaire thermosensible reversible: la synthèse du RNA nucléolaire. J. Micr. 6, 82a (1967)

    Google Scholar 

  148. Simard, R., Amalric, F., Zalta, J.P.: Effect de la température supra-optimale sur les ribonuclêoprotéines et le RNA nucléolaire; I. Etude ultrastructurale. Exp. Cell. Res. 55, 359 (1969)

    PubMed  CAS  Google Scholar 

  149. Simard, R., Bernhard, W.: A heat-sensitive cellular function located in the nucleolus. J. Cell Biol. 34, 61 (1967)

    PubMed  CAS  Google Scholar 

  150. Simard, R., Langelier, Y., Mandeville, R., Maestracci, N., Royal, A.: Inhibitors as tools in elucidating the structure and the function of the nucleus. In: The Cell Nucleus. Busch, H. (ed.), Vol. 3, 447. New York: Academic Press (1974)

    Google Scholar 

  151. Sinensky, M.: Homeoviscous adaption. A homeostatic process that regulates the viscosity of membrane lipids in Escherichia coli. Proc. nat. Acad. Sci. (Wash.) 71, 522 (1974)

    CAS  Google Scholar 

  152. Sisken, J.E., Morasca, L., Kibby, S.: Effects of temperature on the kinetics of the mitotic cycle of mammalian cells in culture. Exp. Cell Res. 39, 103 (1965)

    PubMed  CAS  Google Scholar 

  153. Smith, G.G., Ruwart, M.T., Huang, A.: Lipid phase transitions in membrance vescicles from Thermoplasma acidophila. FEBS Lett. 45, 96 (1974)

    PubMed  CAS  Google Scholar 

  154. Sogin, S.J., Ordal, Z.J.: Regeneration of ribosomes and ribosomal ribonucleic acid during repair of thermal injury to Staphylococcus aureus. J. Bact. 94, 1082 (1967)

    PubMed  CAS  Google Scholar 

  155. Spier, H.L., van Senden, K.G.: Phase transition of cholesterol. Steroids 6, 871 (1965)

    PubMed  CAS  Google Scholar 

  156. Steim, J.M., Tourtellotte, M.E., Reinert, J.C., Mcelhaney, R.N., Rader, R.L.: Calorimetric evidence for the liquid crystalline state of lipids in a biomembrane. Proc. nat. Acad. Sci. (Wash.) 63, 104 (1969)

    CAS  Google Scholar 

  157. Streisinger, G., Mukai, F., Dreyer, W.J., Miller, B., Horiuchi, S.: Mutations affecting the lysozyme of phage T4. Cold Spr. Harb. Symp. quant. Biol. 26, 25 (1961)

    CAS  Google Scholar 

  158. Strom, R.: Ricerche sul meccanismo d’azione del calore sui tumori. Atti Soc. It. Cancerol. Turin 1970, Vol. VII, Pt. 2, p. 49

    Google Scholar 

  159. Strom, R., Caiafa, P., Mondovi, B., Rossi-Fanelli, A.: Effect of temperature on potassium-dependent stimulation of trans- cellular migration in normal and neoplastic cells. FEBS Lett. 3, 343 (1969)

    PubMed  CAS  Google Scholar 

  160. Strom, R., Caiafa, P., Mondovi, B., Rossi-Fanelli, A.: Temperature dependence of transcellular migration of glutamate in normal and neoplastic cells. In: Permeability and function of Biological Membrances. Bolis, L., Katchalsky, A., Keynes, R.D., Lowenstein, W.R., Pethica, B.A. (eds.). Amsterdam: North Holland Publ. Co., 1970, p. 333

    Google Scholar 

  161. Strom, R., Crifo, C., Bozzi, A., Rossi-Fanelli, A.: Inhibition by elevated temperatures of ribosomal RNA maturation in Ehrlich ascites cells. Cancer Biochem. Biophys. 1, 57 (1975)

    CAS  Google Scholar 

  162. Strom, R., Scioscia Santoro, A., Crifo, C., Bozzi, A., Mondovi, B., Rossi-Fanelli, A.: The biochemical mechanism of selective heat sensitivity of cancer cells. IV. Inhibition of RNA synthesis. Europ. J. Cancer 9, 103 (1973)

    CAS  Google Scholar 

  163. Szybalski, W.: Effect of elevated temperatures of DNA and on some polynucleotides: denaturation renaturation and cleavage of glycosidic and phosphate ester bonds. In: Thermobiology. Rose, A.N. (ed.) London: Academic Press, 1967, p. 73

    Google Scholar 

  164. Szybalski, W., Opara-Kubinska, Z.: Cellular Radiation Biology. Baltimore: Williams and Wilkins Co., 1965

    Google Scholar 

  165. Tecce, G., Toschi, G.: A study of ribosomes from a thermophilic microorganism. Suppl. Nuovo Cimento 18, 207 (1966)

    Google Scholar 

  166. Thompson, L.H., Baker, R.M.: Isolation of mutants of cultured mammalian cells. In: Methods in Cell Physiology. Prescott, D.M. (ed.) New York: Academic Press, Vol. VI, 1973, p. 209

    Google Scholar 

  167. Toniolo, D., Meiss, H.K., Basilico, C.: A temperature-sensitive mutation affecting 28 S ribosomal RNA production in mammalian cells. Proc. nat. Acad. Sci. (Wash.) 70, 1273 (1973)

    CAS  Google Scholar 

  168. Turano, C., Ferraro, A., Strom, R., Cavaliere, R., Rossi-Fanelli, A.: The biochemical mechanism of selective heat sensitivity of cancer cells. III. Studies on lysosomes. Europ. J. Cancer 6, 67 (1970)

    CAS  Google Scholar 

  169. Udaka, S., Horiuchi, T.: Mitants of Escherichia coli having temperature sensitive regulatory mechanism in the formation of arginine biosynthetic enzymes. Biochim. bioühys. Res. Commun. 19, 156 (1965)

    CAS  Google Scholar 

  170. Vermel, E.M., Kuznetsova, L.B.: Hyperthermia in the treatment of malignant diseases (in Russian). Probl. Oncol. USSR 16, 96 (1970)

    CAS  Google Scholar 

  171. Vollmar, H.: Über den Einfluß der Temperatur auf normales Gewebe und auf Tumorgewebe. Z. Krebsforsch. 51, 71 (1941)

    Google Scholar 

  172. Warocquier, R., Scherrer, R.: RNA-metabolism in mammalian cells at elevated temperature. Europ. J. Biocheipi. 10, 362 (1969)

    CAS  Google Scholar 

  173. Weinberg, R.A.: Nuclear RNA metabolism. Ann. Rev. Biochem. 42, 329 (1973)

    PubMed  CAS  Google Scholar 

  174. Westermark, N.: The effect of heat upon rat tumors. Scand. Arch. Physiol. 52, 257 (1927)

    Google Scholar 

  175. Westra, A., Dewey, W.C.: Variation in sensitivity to heat shock during the cell cycle of Chinese hamster cells in vitro. Int. J. Radiat. Biol. 19, 467 (1971)

    CAS  Google Scholar 

  176. White, H.R.: The heat resistance of Streptococcus faecalis. J. gen. Microbiol. 8, 27 (1953)

    PubMed  CAS  Google Scholar 

  177. Wilson, G., Rose, S.P., Fox, C.F.: The effect of membrane lipid unsaturation on glycoside transport. Biochim. biophys. Res. Commun. 38, 617 (1970)

    CAS  Google Scholar 

  178. Wood, T.H.: Lethal effects of high and low temperatures on unicellular organisms. Advanc. biol. med. Phys. 4, 1 19 (1956)

    Google Scholar 

  179. Woodcock, E., Grigg, C.W.: Repair of thermally induced DNA breakage in Escherichia coli. Nature (New Biol.) 237, 76 (1972)

    CAS  Google Scholar 

  180. Yerushalmi, A., Har-Kedar, I.: Enhancement of radiation effects by heating of the tumor. Israel J. med. Sci. 10, 772 (1974)

    CAS  Google Scholar 

  181. Yoshizaki, F., Oshima, T., Imahori, K.: Studies on phosphogluco- mutase from an extreme thermophile Flavobacterium thetmophilum HB8. I. Thermostability and other enzymatic properties. J. Biochem. (Tokyo) 69, 1083 (1971)

    CAS  Google Scholar 

  182. Zamenhof, S.: Effects of heating dry bacteria and spores on their phenotype and genotype. Proc. nat. Acad. Sci. (Wash.) 46, 101 (1960)

    CAS  Google Scholar 

  183. Zamenhof, S., Green, S.: Heat as agent producing high frequency of mutations and unstable genes in E. coli. Nature (Lond.) 182, 611 (1958)

    CAS  Google Scholar 

  184. Zeikus, J.G., Brock, T.D: Protein synthesis at high temperatures: aminoacylation of t-RNA. Biochim. biophys. Acta 228, 736 (1971)

    CAS  Google Scholar 

  185. Zeikus, J.G., Taylor, M.W., Brock, T.D.: Thermal stability of ribosomes and RNA from Thermus aquaticus. Biochim. biophys. Acta 204, 512 (1970)

    CAS  Google Scholar 

Download references

Authors
  1. R. Strom
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. Crifo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Rossi-Fanelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. B. Mondovi
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institute of Biological Chemistry, University of Rome, Rome, Italy

    Alessandro Rossi-Fanelli

  2. Center of Molecular Biology, C.N.R., Rome, Italy

    Alessandro Rossi-Fanelli

  3. Regina Elena Institute for Cancer Research, Rome, Italy

    Renato Cavaliere  & Guido Moricca  & 

  4. Institute of Applied Biochemistry, University of Rome, Rome, Italy

    Bruno Mondovì

Rights and permissions

Reprints and permissions

Copyright information

© 1977 Springer-Verlag Berlin · Heidelberg

About this chapter

Cite this chapter

Strom, R., Crifo, C., Rossi-Fanelli, A., Mondovi, B. (1977). Biochemical Aspects of Heat Sensitivity of Tumour Cells. In: Rossi-Fanelli, A., Cavaliere, R., Mondovì, B., Moricca, G. (eds) Selective Heat Sensitivity of Cancer Cells. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 59. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81080-0_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-81080-0_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81082-4

  • Online ISBN: 978-3-642-81080-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation