Non-Simultaneously Diagnosed Multiple Primary Malignant Neoplasms: General Considerations

  • Bruce S. Schoenberg
Part of the Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer book series (RECENTCANCER, volume 58)


In the case of non-simultaneously occurring multiple primary malignancies, available methods allow one to compare the observed and expected number of second primary cancers. Without the presence of an adequate control group, it is impossible to evaluate whether a reported association between two cancers simply represents a chance occurrence. It is imperative always to question whether a reported association is real or artifactual. In examining results of such investigations, one must constantly consider certain possibilities for bias. Problems inherent in the use of data from selected populations, establishing adequate statistical techniques, and utilizing a proper control population have already been discussed in Chapter 1.


Skin Cancer Acoustic Neuroma Uterine Corpus Multiple Primary Cancer Chronic Lymphatic Leukemia 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1977

Authors and Affiliations

  • Bruce S. Schoenberg
    • 1
    • 2
    • 3
    • 4
  1. 1.Department of Medical Statistics and Epidemiology and Department of NeurologyMayo ClinicRochesterUSA
  2. 2.National Cancer InstituteUSA
  3. 3.Department of Epidemiology and Public HealthYale University School of MedicineUSA
  4. 4.Department of NeurologyGeorgetown University School of MedicineUSA

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