Skip to main content

Some Thoughts Concerning the Primary Therapy of Breast Cancer

  • Chapter

Abstract

When consideration is given to recent advances and progress made in the. treatment of cancer, little attention is directed toward those changes which are taking place that are probably as profound and as of far-reaching in consequence as are any in our time. To many — particularly those in other disciplines — the surgical approach to cancer is deemed anachronistic in concept. While categorically such may be true, the leading edge of that speciality is attempting to redefine the basis for cancer surgery so that it is in keeping with present understanding of tumor biology.

From the Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15261

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. BARTELS, F.: Das Lymphgefäßsystem. Jena: Gustav Fischer, 1909.

    Google Scholar 

  2. DEWYS, W.D.: Studies correlating the growth rate of a tumor and its metastases and providing evidence for tumor related systemic growth retarding factors. Cancer Res. 32, 374 (1972).

    PubMed  CAS  Google Scholar 

  3. FISHER, B., CARBONE, P., EXONOMOU, S.G., FRELICK, R., GLASS, A., LERNER, H., REDMOND, C., ZELEN, M., KATRYCH, D.L., WOLMARK, N., BAND, P., FISHER, E.R., and Other Cooperating Investigators: 1-Phenylalanine mustard (L-PAM) in the management of primary breast cancer: A report of early findings. N. Engl. J. Med. 292, 117 (1975a).

    Article  PubMed  CAS  Google Scholar 

  4. FISHER, B., FISHER, E.R.: Transmigration of lymph nodes by tumor cells. Science, 152, 1397 (1966a).

    Article  PubMed  CAS  Google Scholar 

  5. FISHER, B., FISHER, E.R.: Interrelationship of hematogenous and lymphatic tumor cell dissemination. Surg. Gynecol. Obstet. 122, 791 (1966b).

    PubMed  CAS  Google Scholar 

  6. FISHER, B., FISHER, E.R.: The barrier function of the lymph node to tumor cells and erythrocytes. I. Normal nodes. Cancer 20, 1907 (1967a).

    Article  PubMed  CAS  Google Scholar 

  7. FISHER, B., FISHER, E.R.: The barrier function of the lymph node to tumor cells and erythrocytes. II. Effect of x-ray, inflammation, sensitization and tumor growths. Cancer 20, 1914 (1967b).

    Article  PubMed  CAS  Google Scholar 

  8. FISHER, B., FISHER, E.R.: Role of the lymphatic system in dissemination of tumor. In: Lymph and the Lymphatic System. Springfield, Ill.: Charles C. Thomas, 342–347 (1968).

    Google Scholar 

  9. FISHER, B., SAFFER, E.A., FISHER, E.R.: Studies concerning the regional lymph node in cancer. III. Response of regional lymph node cells from breast and colon cancer patients to PHA stimulation. Cancer 30, 1202 (1972).

    Article  PubMed  CAS  Google Scholar 

  10. FISHER, B., SLACK, N., KATRYCH, D.L., WOLMARK, N.: Ten year follow-up of breast cancer patients in a cooperative clinical trial evaluating surgical adjuvant chemotherapy. Surg. Gynecol. Obstet. 140, 528 (1975b).

    CAS  Google Scholar 

  11. FRINDEL, E., MALAISE, E.P., ALPEN, E., TUBIANA: Kinetics of cell proliferation of an experimental tumor. Cancer Res. 27, 1122 (1967).

    PubMed  CAS  Google Scholar 

  12. HALSTED, W.S.: The results of radical operations for the cure of carcinoma of breast. Ann. Surg. 46, 1 (1907).

    Article  PubMed  CAS  Google Scholar 

  13. HALSTED, W.S.: The treatment of wounds with especial reference to the value of the blood clot in the management of dead spaces. John Hopkins Hosp. Rep. 2, 255 (1890–1891).

    Google Scholar 

  14. LAIRD, A.K., Dynamics of tumor growth. Br. J. Cancer, 18, 490 (1964).

    Article  Google Scholar 

  15. McCredie, J.A., Inch, W.R., Kruuv, J., Watson, T.A.: The rate of tumor growth in animals Growth 29, 331 (1965).

    Google Scholar 

  16. PATEY, D.H.: A review of 146 cases of carcinoma of the breast operated on between 1930 and 1943. Br. J. Cancer, 21, 260 (1967).

    Article  PubMed  CAS  Google Scholar 

  17. PILCH, Y.H., RIGGINS, R.S.: Antibodies to spontaneous and MC-in-duced tumors in inbred mice. Cancer Res. 26, 871 (1966).

    PubMed  CAS  Google Scholar 

  18. SCHABEL, F.M., Jr.: Concepts for systemic treatment of micrometa-stases. Cancer 35, 15 (1975).

    Article  PubMed  CAS  Google Scholar 

  19. SCHABEL, F.M., Jr.: The use of tumor growth kinetics in planning “curative” chemotherapy of advanced solid tumors. Cancer Res. 29, 2384 (1969).

    PubMed  Google Scholar 

  20. SKIPPER, H.E.: Combination Therapy, Booklet 13, Southern Research Institute, Birmingham, Alab. p. 1, December, 1974.

    Google Scholar 

  21. VIRCHOW, R.: Cellular Pathology, Philadelphia: J.B. Lippincott Company (1863).

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1976 Springer-Verlag Berlin · Heidelberg

About this chapter

Cite this chapter

Fisher, B. (1976). Some Thoughts Concerning the Primary Therapy of Breast Cancer. In: St-Arneault, G., Band, P., Israël, L. (eds) Breast Cancer. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 57. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81043-5_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-81043-5_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81045-9

  • Online ISBN: 978-3-642-81043-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics