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The Carcinogenic Properties of Some of the Principal Drugs Used in Clinical Cancer Chemotherapy

  • Chapter
The Ambivalence of Cytostatic Therapy

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 52))

Abstract

Years ago, a team at the Chester Beatty Research Institute in London made the important observation that active cancer chemotherapeutic agents might also be carcinogenic (6). Thus, they discovered the potent carcinogenicity of 4- aminostilbene and derivatives. This concept, however, was not universally recognized and applied. In fact, it was rediscovered with one of the drugs developed at the Chester Beatty Research Institute, namely chlornaphazine. This drug was successful in leading to remissions of Hodgkins’ disease and related neoplastic conditions, but the patients so treated developed cancer in the urinary bladder some years later (1).

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Authors
  1. J. H. Weisburger
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  2. D. P. Griswold
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  3. J. D. Prejean
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  4. A. E. Casey
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  5. H. B. Wood
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  6. E. K. Weisburger
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Editor information

Editors and Affiliations

  1. Pathologisches Institut, 4400, Münster, Westring 17, Germany

    Ekkehard Grundmann

  2. Medizinische Universitätsklinik, Joseph-Stelzmannstr. 9, 5000, Köln 41, Germany

    Rudolf W. J. Gross

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© 1975 Springer-Verlag Berlin · Heidelberg

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Weisburger, J.H., Griswold, D.P., Prejean, J.D., Casey, A.E., Wood, H.B., Weisburger, E.K. (1975). The Carcinogenic Properties of Some of the Principal Drugs Used in Clinical Cancer Chemotherapy. In: Grundmann, E., Gross, R.W.J. (eds) The Ambivalence of Cytostatic Therapy. Recent Results in Cancer Research, vol 52. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80940-8_1

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  • DOI: https://doi.org/10.1007/978-3-642-80940-8_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80942-2

  • Online ISBN: 978-3-642-80940-8

  • eBook Packages: Springer Book Archive

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