Preliminary Studies on the Effect of Calcium on the Enzymatic Degradation of Human Calcitonin on the Dog

  • G. V. Foster
  • D. L. Gildersleeve
  • Chi-Li Kuo
  • D. T. Kelly
  • W. W. Nichols
  • T. A. Pearson
Conference paper

Abstract

In preliminary studies it has been observed that plasma from some patients with hypercalcemia degrades calcitonin in vitro more readily than plasma from normal subjects (BAYLIN et al., unpublished data). In this paper we report the results of investigations in animals which suggest that acute elevations in plasma calcium may stimulate destruction of the hormone by the kidney.

Keywords

Permeability Catheter EDTA Enzymatic Degradation Calcitonin 

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References

  1. BAYLIN, S.B., MALOY, M.A., FOSTER, G.V.: unpublished data.Google Scholar
  2. CHARBON, G.A., PIEPER, E.M.: Influence of calcitonin on parathyroid hormone-induced augmentations of arterial hepatic and renal blood flow. In: Calcitonin 1969: Proceedings of the Second International Symposium (S. Taylor and G.V. Foster, Eds.), pp. 451–457. London: Heinemann Medical Books 1970.Google Scholar
  3. CLARK, M.B., BOYD, G.W., BYFIELD, P.G.H., FOSTER, G.V.: A radioimmunoassay for human calcitonin. Lancet II, 74–76 (1969).CrossRefGoogle Scholar
  4. FOSTER, G.V., CLARK, M.B., WILLIAMS, C., NATHANSON, B.M., HORTON, R., BURANAPONG, P., GLASS, H.I.: Metabolic fate of human calcitonin in the dog. In: Endocrinology 1971 (S. Taylor Ed.), pp. 71–78. London: Heinemann Medical Books 1972.Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1975

Authors and Affiliations

  • G. V. Foster
  • D. L. Gildersleeve
  • Chi-Li Kuo
  • D. T. Kelly
  • W. W. Nichols
  • T. A. Pearson

There are no affiliations available

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