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Chromosomal Alterations and Development of Experimental Tumors

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Geschwülste · Tumors II

Part of the book series: Handbuch der allgemeinen Pathologie ((1712,volume 6 / 6))

Abstract

A tumor is an uncontrollable autonomous growth occurring in the cells of an organism through a continuous series of descendant cell generations. Somatic mutation, which was first proposed by BOVERI (1914), is a widely accepted explanation of the autonomous multiplication of cells. Since publication of his findings, many cytologists have devoted their attention to nuclear division and other karyological phenomena of such cells.

Contribution No. 944 from the National Institute of Genetics, Japan. This study was supported by grant-in-aid from the Ministry of Education of Japan, and in a part by a research grant from the National Cancer Institute (CA 07798), U.S.A.

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References

  • Agnish, N., Fedoroff, S.: Tumor cell population of the Ehrlich ascites tumors. Canad. J. Genet. Cytol. 10, 723–746 (1968).

    PubMed  CAS  Google Scholar 

  • Al-Saadi, A., Beierwaltes, W.H.: Sequential cytogenetic changes in the evolution of transplanted thyroid tumors to metastatic carcinoma in the Fisher rat. Cancer Res. 27, 1831–1842 (1967).

    PubMed  CAS  Google Scholar 

  • Atkin, N. B.: Cytogenetic studies on human tumors and premalignant lesions: The emergence of aneuploid cell lines and their relationship to the process of malignant transformation in man. In: Genetic concepts and neoplasia, p. 36–56. Baltimore: Williams and Wilkins 1970.

    Google Scholar 

  • Atkin, N.B., Mattinson, G., Baker, M.C.: A comparison of the DNA content and chromosome number of fifty human tumors. Brit. J. Cancer 20, 87–101 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Auerbach, C.: D. melanogaster: New mutants. Chemically induced mutations and rearangement. Dros. Inform. Service. 17, 48 (1943).

    Google Scholar 

  • Bayreuther, K.: Der Chromosomenbestand des Ehrlich-Ascites-Tumors der Maus. Z. Naturforsch. 7, 554–557(1952).

    Google Scholar 

  • Bayreuther, K.: Chromosomes in primary neoplastic growth. Nature (Lond.) 186, 6–9 (1960).

    Article  CAS  Google Scholar 

  • Berger, R.: Chromosomes et leucémies humaines. La notion d’évolution clonale. Ann. Génét. 8, 70–82 (1965).

    PubMed  CAS  Google Scholar 

  • Biesele, J.J., Poyner, H., Painter, T.S.: Nuclear phenomena in mouse cancers. Univ. Texas Publ. 4243, 7–68 (1942).

    Google Scholar 

  • Biesele, J.J., Biedler, J.L., Hutchison, D.J.: The chromosomal status of drug resistant sublines of mouse leukemia L1210. In: Genetics and Cancer, p. 295–307. Austin, Texas: Univ. Texas Press 1959.

    Google Scholar 

  • Blakeslee, A.F., Avery, A.G.: Methods of inducing doubling of chromosomes in plants. J. Hered. 28, 393–411 (1937).

    CAS  Google Scholar 

  • Bottomley, R.H., Trainer, A.L., Griffin, M.J.: Enzymatic and chromosomal characterization of HeLa variants. J. Cell Biol. 41, 806–815 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Boveri, T.: Zur Frage der Entstehung maligner Tumoren. Jena: Fischer 1914.

    Google Scholar 

  • Cailleau, R.: Establishment of two mouse ascites tumors in tissue culture: Ehrlich carcinoma and L-4946. Abs. American Tissue Culture Assoc., Chicago, pp. 26, 1960.

    Google Scholar 

  • Chu, E.H.Y., Malmgren, R.A.: Microspectrophotometric determination of deoxyribonucleic acid in primary and metastatic mouse mammary tumors. J. nat. Cancer Inst. 27, 217–220 (1961).

    PubMed  CAS  Google Scholar 

  • Chu, E.H.Y., Sanford, K.K., Earle, W.R.: Comparative chromosome studies on mammalian cells in culture. II. Mouse sarcoma-producing cell strains and their derivatives. J. nat. Cancer Inst. 21, 729–752 (1958).

    PubMed  CAS  Google Scholar 

  • Cooper, H.L., Black, P.H.: Cytogenetic studies of hamster kidney embryonic cell cultures transformed by the simian vacuolating virus (SV-40). J. nat. Cancer Inst. 30, 1015–1043 (1963).

    PubMed  CAS  Google Scholar 

  • Cornil, V.: Mode de multiplication des noyaux et des cellules dans l’épithéliome. J. de l’anat. et Physiol. 27, 97–116 (1891).

    Google Scholar 

  • Craigie, J.: Further observation on tumor cells in the paramorphic or “dormant” resistant state. J. Path. Bact. 64, 251–252 (1952).

    PubMed  CAS  Google Scholar 

  • Darlington, C.D., Koller, P.C.: The chemical breakage of chromosomes. Heredity 1, 187–221 (1947).

    Article  Google Scholar 

  • Dawe, C.J., Potter, M.: Morphologic and biologic progression of the lymphoid neoplasm of the mouse in vivo and in vitro. Amer. J. Path. 33, 603 (1957).

    Google Scholar 

  • De Bruyn, W.M., Hansen-Melander, E.: Chromosome studies on the MB mouse lymphosarcoma. J. nat. Cancer Inst. 28, 1333–1354 (1962).

    Google Scholar 

  • Defendi, V., Manson, L.A.: Analysis of the life-cycle in mammalian cells. Nature (Lond.) 198, 359–361 (1963).

    Article  Google Scholar 

  • De Grouchy, J.: Aberrations chromosomiques et processus Malins. Ann. Génét. 9, 55–57 (1966).

    PubMed  Google Scholar 

  • Di Paolo, J.A.: Establishment of long term cultures of Ehrlich ascites tumor cells. Proc. Soc. exp. Biol. (N. Y.) 109, 616–618 (1962).

    Google Scholar 

  • Earle, W.R.: Production of malignancy in vitro. IV. The mouse fibroblast cultures and changes seen in the living cells. J. nat. Cancer Inst. 4, 165–212 (1943).

    CAS  Google Scholar 

  • Ely, J.O., Gray, J.H.: Chromosome number of in vivo and in vitro cultured krebs-2 carcinoma of mice: The selective property of the in vitro culture medium. Cancer Res. 21, 1020–1023 (1961).

    PubMed  CAS  Google Scholar 

  • Evans, V.J., Parker, G.A., Dunn, T.B.: Neoplastic transformations in C3H mouse embryonic tissue in vitro determined by intraocular growth. I. Cells from chemically defined medium with and without serum supplement. J. nat. Cancer Inst. 32, 89–122 (1964).

    PubMed  CAS  Google Scholar 

  • Farmer, J.B., Moore, J.E.S., Walker, C.E.: On the resemblances between the cells of malignant growths in man and those of normal reproductive tissues. Proc. roy. Soc. B. 72, 499–504 (1904).

    Google Scholar 

  • Feldman, M., Sachs, L.: Immunogenetic properties of tumors that have acquired homotransplantability. J. nat. Cancer Inst. 20, 513–539 (1958).

    PubMed  CAS  Google Scholar 

  • Ferguson, J., Tomkins, G. A.: Chromosome studies during long-term cultivation of epitheloid cerco- pithecus and cynomolgus monkey kidney cell lines. J. nat. Cancer Inst. 33, 619–630 (1964).

    PubMed  CAS  Google Scholar 

  • Finkelstein, M., Winters, W.D., Thomas, P.A., Davidson, C., Smith, P.K.: The effect of 8- azaguanine on tissue metabolism in mice bearing sarcoma 37. Cancer Res. 11, 807–810 (1951).

    PubMed  CAS  Google Scholar 

  • Fjelde, A., Lev an, A., Rask-Nielsen, R.: The chromosomes of four transplantable murine plasma cell leukemias characterized by varying pathological serum protein changes and/or amyloid formation. Hereditas (Lund) 48, 630–644 (1962).

    Google Scholar 

  • Ford, C.E., Clarke, C.M.: Cytogenetic evidence of clonal proliferation in primary reticular neoplasms. Canad. Cane. Conf. 5, 129–146 (1963).

    CAS  Google Scholar 

  • Ford, C.E., Hamarton, J.L.: A colchicine, hypotonic citrate, squash sequence for mammalian chromosomes. Stain Technol. 31, 247–251 (1956).

    PubMed  CAS  Google Scholar 

  • Ford, C.E., Hamerton, J.L., Mole, R.H.: Chromosomal changes in primary and transplanted reticular neoplasms of the mouse. J. cell. comp. Physiol. 52, Suppl. 1, 235–269 (1958).

    Article  CAS  Google Scholar 

  • Ford, D.K., Yerganian, G.: Observations on the chromosomes of Chinese hamster cells in tissue culture. J. nat. Cancer Inst. 21, 393–425 (1958).

    PubMed  CAS  Google Scholar 

  • Goldie, H., Hahn, P.F.: Effects of radioactive iodine on free sarcoma cells in the peritoneal fluid of the mouse. Proc. Soc. exp. Biol. (N. Y.) 74, 634–638 (1950).

    CAS  Google Scholar 

  • Glass, E.: Die chromosomalen Veränderungen in der Rattenleber während der krebsigen Entartung nach Verfütterung von Buttergelb. Z. Krebsforsch. 63, 294–310 (1960).

    Article  Google Scholar 

  • Guenin, H. A.: Les hétérochromosomes dans l’ovogenèse des mammiferes. J. Génét. 49, 23–37 (1948).

    PubMed  CAS  Google Scholar 

  • Guyer, M.F., Claus, P.E.: Relative viscosities of tumor cells as determined by the ultracentrifuge. Anat. Ree. 73, 17–23 (1939).

    Article  Google Scholar 

  • Hakala, M.T., Ishihara, T.: Chromosomal constitution and amethopterin resistance in cultured mouse cells. Cancer Res. 22, 987–992 (1962).

    PubMed  CAS  Google Scholar 

  • Hansemann, D. von: Über asymmetrische Zellteilung in Epithelkrebsen und deren biologische Bedeutung. Virchows Arch. path. Anat. 119, 299–326 (1890).

    Google Scholar 

  • Hansen-Melander, E.: Accelerated evolution of cancer stemline following environmental changes. Hereditas 44, 471–487 (1958).

    Article  Google Scholar 

  • Harris, M., Ruddle, F.H.: Growth and chromosome studies on drug resistant lines of cells in tissue culture. In: Cell Physiology of Neoplasia, p. 524–546. Austin, Texas: Univ. Texas Press.

    Google Scholar 

  • Hauschka, T.S.: Cell population studies on mouse ascites tumors. Trans. N.Y. Acad. Sci. Sec. II. 16, 64–73 (1953).

    Google Scholar 

  • Hauschka, T.S.: Correlation of chromosomal and physiologic changes in tumors. J. cell. comp. Physiol. 52 (Suppl.), 197–234 (1958).

    Article  CAS  Google Scholar 

  • Hauschka, T.S., Kvedar, B.J., Grinnell, S.T., Amos, D.B.: Immunoselection of polyploids from predominantly diploid cell populations. Ann. N.Y. Acad. Sci. 63, 683–705 (1956).

    Article  PubMed  CAS  Google Scholar 

  • Hauschka, T. S., Lev an, A.: Cytological and functional characterization of single cell clones isolated from the krebs-2 and Ehrlich ascites tumors. J. nat. Cancer Inst. 21, 77–135 (1958).

    PubMed  CAS  Google Scholar 

  • Hayflick, L., Moorhead, P.S.: The serial cultivation of human diploid cell strains. Exp. Cell Res. 25, 585–621 (1961).

    Article  Google Scholar 

  • Heiberg, K.A.: Über die Erklärung einer Verschiedenheit der Krebszellen von anderen Zellen. Nord. med. Ark. 41, Afd. II. Häft 1, 1–20 (1908).

    Google Scholar 

  • Heiberg, K.A., Kemp, T.: Über die Zahl der Chromosomen in Carzinomzellen beim Menschen. Virchows Arch. path. Anat. 273, 693–700 (1929).

    Article  Google Scholar 

  • Hellstrom, K. E.: Chromosomal studies on primary methylcholanthrene-induced sarcomas in the mouse. J. nat. Cancer Inst. 23, 1019–1033 (1959).

    PubMed  CAS  Google Scholar 

  • Hirai, Y., Takizawa, T.: Experimental studies on the mechanism of quinone carcinogenesis. First report. Gann 42, 91–94 (1951).

    CAS  Google Scholar 

  • Hirono, I.: Some observations on the mitosis of the living malignant tumor cells (studies on Yoshida sarcoma cells). Acta path. jap. 1, 40–47 (1951).

    Google Scholar 

  • Hsu, T.C.: Cytological studies on HeLa. 1. Observations on mitosis and chromosomes. Tex. Rep. Biol. Med. 12, 833–846 (1954).

    PubMed  CAS  Google Scholar 

  • Hsu, T.C.: Mammalian chromosomes in vitro. XI. Variability among progenies of a single cell. Univ. Tex. Publ. 5914, 129–134 (1959).

    Google Scholar 

  • Hsu, T.C.: Chromosomal evolution in cell populations. Int. Rev. Cytol. 12, 69–102 (1961).

    Article  PubMed  CAS  Google Scholar 

  • Hsu, T. C., Billen, D., Lev an, A.: Mammalian chromosomes in vitro. XV. Patterns of transformation. J. nat. Cancer Inst. 27, 515–541 (1961).

    PubMed  CAS  Google Scholar 

  • Hsu, T.C., Kellogg, D.G.: Genetics of in vitro cells. In: Genetics and Cancer, p. 183–204. Austin, Texas: Univ. of Texas Press 1959.

    Google Scholar 

  • Hsu, T.C., Klatt, O.: Mammalian chromosomes in vitro. IX. On genetic polymorphism in cell population. J. nat. Cancer Inst. 21, 434–473 (1958).

    Google Scholar 

  • Hsu, T. C., Klatt, O.: Mammalian chromosomes in vitro. X. Heteroploid transformation in neoplastic cells. J. nat. Cancer Inst. 22, 313–339 (1959).

    PubMed  CAS  Google Scholar 

  • Hsu, T.C., Moorhead, P.S.: Mammalian chromosomes in vitro. VII. Heteroploidy in human cell strains. J. nat. Cancer Inst. 18, 463–471 (1957).

    PubMed  CAS  Google Scholar 

  • Hsu, T.C., Pomerat, C.M.: Mammalian chromosomes in vitro. II. A method for spreading the chromosomes of cells in tissue culture. J. Hered. 44, 23–29 (1953).

    Google Scholar 

  • Hsu, T.C., Pomerat, C.M., Moorhead, P.S.: Mammalian chromosomes in vitro. VIII. Heteroploid transformation in the human cell strain Mayes. J. nat. Cancer Inst. 19, 867–873 (1958).

    Google Scholar 

  • Huang, C.C., Strong, L.G.: The chromosomes of the 7,12-dimethylbenz(a)anthracene-induced tumors in Mastomys. Cancer Res. 23, 1800–1807 (1963).

    PubMed  CAS  Google Scholar 

  • Ida, N., Fukuhara, A., Ohba, Y.: Several aspects of vertical transmission of Moloney virus. J. nat. Cancer Inst. 22, 287–311 (1966).

    CAS  Google Scholar 

  • Inui, N.: Comparative studies on the content of deoxyribonucleic acid in four gastric carcinomas and their metastatic lesions. Gann 54, 331–338 (1963).

    CAS  Google Scholar 

  • Inui, N., Yosida, T.H.: Chromosomal alteration and the development of tumors, X. Karyological observations of ascites tumors and metastatic tumors of MH-134 mouse hepatoma. Gann 55, 49–55 (1964).

    PubMed  CAS  Google Scholar 

  • Ishihara, T., Yosida, T.H.: Some genetical aspects of transplantability of the MY-mouse sarcoma. Jap. J. Genet. 33, 23–27 (1958).

    Article  Google Scholar 

  • Ising, U.: Chromosome studies in Ehrlich mouse ascites cancer after heterologous transplantation through hamsters. Brit. J. Cancer 9, 592–599 (1955).

    Article  PubMed  CAS  Google Scholar 

  • Ising, U.: Effect of heterologous transplantation on chromosomes of ascites tumors. Acta path, microbiol. scand. Suppl. 127, 1–102 (1958).

    Google Scholar 

  • Kano, K.: Observation of the chromosomes in the Hirosaki sarcoma of rats. La Kromosomo 15, 555–562 (1953).

    Google Scholar 

  • Kano, K., Tanaka, T.: Some cytological features of the MKT-sarcomas in comparison with those of the Yoshida sarcoma. Pap. Coord. Committ. Res. Genet. 3, 179–184 (1952).

    Google Scholar 

  • Kato, R.: The chromosomes of forty-two primary Rous sarcoma of the Chinese hamster. Hereditas 59, 63–119 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Katsuta, H., Takaoka, T., Doida, Y., Kuroki, T.: Carcinogenesis in tissue culture. VII. Morphological transformation of rat liver cells in Nagisa culture. Jap. J. exp. Med. 55, 513–544 (1965).

    Google Scholar 

  • Kaufmann, B.P., McDonald, M.R., Gay, H.: The distribution and interrelations of nucleic acids in fixed cells as shown by enzymatic hydrolyses. J. cell. comp. Physiol. 38 (Suppl. 1), 71–99 (1951).

    Article  CAS  Google Scholar 

  • Kaziwara, K.: Deviation of stable polyploid sublines from a hyperdiploid Ehrlich ascites carcinoma. Cancer Res. 14, 795–801 (1954).

    PubMed  CAS  Google Scholar 

  • Kid, S., Gross, A.L.: Quantitative relationship between DNA content and glycolysis or histones of diploid and tetraploid cells. Biochim. biophys. Acta (Amst.) 36, 185–191 (1959).

    Article  Google Scholar 

  • Klein, E.: Gradual transformation of solid into ascites tumors. Permanent difference between the original and transformed sublines. Cancer Res. 14, 482–485 (1954).

    PubMed  CAS  Google Scholar 

  • Klein, E.: Grandual transformation of solid into ascites tumors. Evidence favoring the mutation- selection theory. Exp. Cell Res. 8, 188–212 (1955 a).

    Article  PubMed  CAS  Google Scholar 

  • Klein, E.: Immediate transformation of solid into ascites tumors. Studies on a mammary carcinoma of an inbred mouse strain. Exp. Cell Res. 8, 213–225 (1955 b).

    Article  PubMed  CAS  Google Scholar 

  • Klein, G.: Comparative studies of mouse tumors with respect to their capacity for growth as “ascites tumors” and their average nucleic acid content per cell. Exp. Cell Res. 2, 518–573 (1951).

    Article  CAS  Google Scholar 

  • Klein, G., Klein, E.: The transformation of solid transplantable mouse carcinomas into “ascites tumors”. Cancer Res. 11, 466–469 (1951).

    PubMed  CAS  Google Scholar 

  • Königsberg, U.R., Nitowsky, H.M.: Studies of the karyotype of clonal strains of Chang liver differing in alkaline-phosphatase activity. J. nat. Cancer Inst. 29, 699–710 (1962).

    PubMed  Google Scholar 

  • Koller, P.C.: A new technique for mitosis in tumors. Nature (Lond.) 149, 193 (1942).

    Article  Google Scholar 

  • Koller, P.C.: Abnormal mitosis in tumors. Brit. J. Cancer 1, 38–46 (1947).

    Article  PubMed  CAS  Google Scholar 

  • Koller, P. C.: Chromosome behaviour in tumors: Readjustments to Boveri’s theory. In: Cell Physiol, of Neoplasia, p. 9–48. Austin, Texas: Univ. Texas press 1960.

    Google Scholar 

  • Koller, P.C.: Chromosomes in cancer biology. Berlin-Heidelberg-New York: Springer 1972.

    Google Scholar 

  • Kurita, Y., Moriwaki, K., Yosida, T. H.: Autoradiographic analysis of the mitotic cycle in Yoshida sarcoma cells. Gann 55, 397–402 (1964).

    PubMed  CAS  Google Scholar 

  • Kurita, Y., Shisa, H., Matsuyama, M., Nishizuka, Y., Tsuruta, R., Yosida, T.H.: Carcinogen- induced chromosome aberrations in hematopoietic cells of mice. Gann 60, 91–95 (1969).

    PubMed  CAS  Google Scholar 

  • Kurita, Y., Sugiyama, T., Nishizuka, Y.: Cytogenetic studies on rat leukemia induced by pulse doses of 7,12-dimethylbenz(a)anthracene. Cancer Res. 28, 1738–1752 (1968).

    PubMed  CAS  Google Scholar 

  • Kurita, Y., Sugiyama, T., Nishizuka, Y.: Chromosome aberrations induced in rat bone marrow cells by 7,12-dimethylbenz(oc)anthracene. J. nat. Cancer Inst. 43, 635–641 (1969).

    CAS  Google Scholar 

  • Kurita, Y., Yosida, T. H.: Chromosomal alteration and the development of tumors. VII. Karyologi- cal analysis of spontaneous and induced leukemias in mice. Gann 52, 257–264 (1961).

    PubMed  CAS  Google Scholar 

  • Kurita, Y., Yosida, T.H., Moriwaki, K.: Nonrandomness in the distribution of chromosome aberrations induced by a radiomimetic chemical, 4-nitroquinoline 1-oxide, in tumor cells. Jap. J. Genet. 40, 365–376 (1965).

    Article  Google Scholar 

  • La Cour, L.: Improvements in everyday technique in plant cytology. J. roy. micr. Soc. 51, 119 (1931).

    Google Scholar 

  • Lejeune, J.: Leucemies et cancers les chromosomes humaines, Ed. Turpin and Lejeune, Paris: Gauthier-Villass 1965.

    Google Scholar 

  • Levan, A.: Colchicine-induced c-mitosis in two mouse ascites tumors. Hereditas 40, 1–64 (1954).

    Article  Google Scholar 

  • Levan, A.: The significance of polyploidy for the evolution of mouse tumors. Exp. Cell Res. 11, 613–629 (1956a).

    Article  PubMed  CAS  Google Scholar 

  • Levan, A.: Chromosomes in cancer tissue. Ann. N.Y: Acad. Sci. 63, 774–792 (1956b).

    Article  CAS  Google Scholar 

  • Lev an, A., Biesele, J.J.: Role of chromosomes in carcinogenesis, as studied in serial tissue culture of mammalian cells. Ann. N.Y. Acad. Sci. 71, 1022–1053 (1958).

    Article  CAS  Google Scholar 

  • Lev an, A., Hauschka, T.S.: Chromosome numbers of three mouse ascites tumors. Hereditas 38, 251–255 (1952).

    Article  Google Scholar 

  • Lev an, A., Hauschka, T.S.: Nuclear fragmentation—a normal feature of the mitotic cycle of lymphosarcoma cells. Hereditas 39, 137–148 (1953).

    Article  Google Scholar 

  • Levine, M.: Studies in cytology of cancer; crown gall disease; historical development. Amer. J. Cancer 15, 144–211, 788–834, 1410–1494 (1931).

    Google Scholar 

  • Lewis, M.R., Lewis, W.H.: Malignant cells of Walker rat sarcoma No. 338. Amer. J. Cancer 16, 1153–1183 (1932).

    Google Scholar 

  • Lewis, W.H.: Cell division with special reference to cells in tissue cultures. Ann. N.Y. Acad. Sci. 51, 1287–1294(1951).

    Article  PubMed  CAS  Google Scholar 

  • Maeda, M., Tabata, T., Kimura, T., Shimada, T., Nishimura, S.: Microspectrophotometric determinations of deoxyribonucleic-acid (DNA) in the primary and metastatic tumors of human in comparison with their chromosome constitutions. Wakayama med. Rep. 11, 105–114 (1966).

    PubMed  CAS  Google Scholar 

  • Makino, S.: The cycle of tumor cells in a transplant generation of the Yoshida sarcoma. Proc. Jap. Acad. 27, 287–291 (1951).

    Google Scholar 

  • Makino, S.: Cytological studies on cancer. III. The characteristics and individuality of chromosomes in tumor cells of the Yoshida sarcoma which contribute to the growth of the tumor. Gann 43, 17–34 (1952 a).

    CAS  Google Scholar 

  • Makino, S.: A cytological study of the Yoshida sarcoma, an ascites tumor of white rats. Chromosoma (Berl.) 4, 649–674 (1952 b).

    Article  CAS  Google Scholar 

  • Makino, S.: Further evidence favoring the concept of the stem cell in ascites tumors of rats. Ann. N.Y. Acad. Sci. 63, 818–830 (1956).

    Article  PubMed  CAS  Google Scholar 

  • Makino, S.: The concept of stemline cells as progenitors of a neoplastic population. Cytologia (Tokyo) Suppl. Vol. (In: Proc. Internat. Genetics Symp., Tokyo, 1956), 177–181 (1957a).

    Google Scholar 

  • Makino, S.: The chromosome cytology of the ascites tumors of rats, with special reference to the concept of the stemline cell. Int. Rev. Cytol. Vol. 6, 26–84 (1957b).

    Google Scholar 

  • Makino, S., Hsu, T.C.: Mammalian chromosomes in vitro. V. The somatic complement of the Norway rat, Rattus norvegicus. Cytologia (Tokyo) 19, 23–28 (1954).

    Article  Google Scholar 

  • Makino, S., Kano, K.: Cytological studies on cancer. II. Daily observations of the mitotic frequency and the variation of the chromosome number in tumor cells of the Yoshida sarcoma through a transplant generation. J. Fac. Sci. Hokkaido Univ. Ser. VI. Zool. 10, 225–242 (1951).

    Google Scholar 

  • Makino, S., Kano, K.: Cytological studies of tumor, IX. Characteristic chromosome individuality in tumor strain-cells in ascites tumors of rats. J. nat. Cancer Inst. 13, 1213–1235 (1953).

    PubMed  CAS  Google Scholar 

  • Makino, S., Kano, K.: Cytological studies of tumors. XIV. Isolation of single-cell clones from a mix-cell tumor of the rat. J. nat. Cancer Inst. 15, 1165–1181 (1955).

    PubMed  CAS  Google Scholar 

  • Makino, S., Nakahara, H.: Cytologische Untersuchungen an Tumoren. VIII. Beobachtungen iiber den Mitoseablauf in lebenden Tumorzellen der Ascitessarkome der Ratten. Z. Krebsforsch. 59, 298–309 (1953).

    Article  PubMed  CAS  Google Scholar 

  • Makino, S., Nishimura, I.: Water-pretreatment squash technique. A new and simple practical method for the chromosome study of animals. Stain Technol. 27, 1–7 (1953).

    Google Scholar 

  • Makino, S., Sasaki, M.: Cytological studies of tumors. XXI. A comparative idiogram study of the Yoshida sarcoma and its subline derivatives. J. nat. Cancer Inst. 20, 465–487 (1958).

    PubMed  CAS  Google Scholar 

  • Makino, S., Tanaka, T.: The cytological effect of chemicals on ascites sarcomas, I. Partial damage in tumor cells by podophyllin, followed by temporary regression and prolongation of life of tumor-bearing rats. J. nat. Cancer Inst. 13, 1185–1199 (1953).

    PubMed  CAS  Google Scholar 

  • Makino, S., Tanaka, T., Kano, K.: Experimental production of the two new ascites-sarcoma similar to Yoshida sarcoma. Gann 42, 199–201 (1951).

    CAS  Google Scholar 

  • Makino, S., Tonomura, A.: Cytological studies of tumors. XV. Reciprocal effects on growth of two different tumors in the same host. Z. Krebsforsch. 60, 597–608 (1955).

    Article  PubMed  CAS  Google Scholar 

  • Makino, S., Yosida, T. H.: Cytological types of abnormal cells in the Yoshida sarcoma. (Preliminary notes on the karyological study in tumors, No. 1). Jap. J. Genet. Suppl. 2, 132–136 (1949).

    Google Scholar 

  • Makino, S., Yosida, T. H.: Cytological studies on cancer, I. Morphological and statistical observations on the abnormal mitosis in tumor cells of the Yoshida sarcoma through a transplant generation. J. Fac. Sci. Hokkaido Univ. Ser. VI. Zool. 10, 209–224 (1951).

    Google Scholar 

  • Mark, J.: Chromosomal analysis of ninety-one primary Rous sarcomas in the mouse. Hereditas 57, 23–82 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Matano, Y.: The rise of a new subline in the MTK-sarcoma II through the change of stemline chromosomes. Jap. J. Genet. 35, 329–336 (1960).

    Article  Google Scholar 

  • Matano, Y., Yosida, T. H.: Alteration of stemline chromosomes in hypotetraploid Ehrlich carcinoma. Proc. Japan Acad. 42, 404–407 (1966).

    Google Scholar 

  • Matsushima, T., Yosida, T.H.: Change of stemline karyotypes in Yoshida sarcoma by appearance of peculiar marker chromosomes. Gann 62, 389–394 (1971).

    PubMed  CAS  Google Scholar 

  • Meek, E.S.: The cellular distribution of DNA in primary and secondary growth of human breast cancer. J. Path. Bact. 82, 167–176 (1961).

    Article  PubMed  CAS  Google Scholar 

  • Mitelman, F.: The chromosomes of fifty primary Rous rat sarcomas. Hereditas 69, 155–186 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Mitelman, F.: Comparative chromosome analysis of primary and metastatic Rous sarcomas in rats. Hereditas 70, 1–14 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Mitelman, F., Lev an, G.: The chromosomes of primary 7,12-dimethylbenz(a)anthracene-induced rat sarcomas. Hereditas 71, 325–334 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Möllendorf, W.V.: Zur Kenntnis der Mitose. X. Über Vorkommen pathologischer Mitosen in Gewebskulturen des Brown-Pearce-Tumors. Zugleich ein Beitrag zur Frage der Tumormitosen. Z. Zellforsch. 31,60–90(1941).

    Article  Google Scholar 

  • Moriwaki, K., Imai, H.T., Yamashita, J., Yosida, T.H.: Ploidy fluctuation of mouse plasma-cell neoplasm MSPC-1 during serial transplantation. J. nat. Cancer Inst. 47, 623–637 (1971).

    PubMed  CAS  Google Scholar 

  • Moriwaki, K., Imai, H.T., Yosida, T.H.: Polyploidization and protein synthesis in mammalian tumor cells. Jap. J. Genet. 44, Suppl. 1:71–83 (1969).

    Google Scholar 

  • Nadler, C. F.: Chromosomal patterns of irradiated and nonleukemic C57BL/6J mice. J. nat. Cancer Inst. 30, 923–931 (1963).

    PubMed  CAS  Google Scholar 

  • Nakahara, H.: Some observations on mitosis in living tumor cells of MTK-I sarcoma. La Kromo- somo 15, 568–672 (1953).

    Google Scholar 

  • Nichols, W.W., Levan, A., Hall, B., Ostergren, G.: Measles-associated chromosome breakage. Hereditas 48, 367–370 (1962).

    Article  Google Scholar 

  • Nichols, W.W.: Relationships of viruses, chromosomes and carcinogenesis. Hereditas 50, 53–80 (1963).

    Article  Google Scholar 

  • Nor well, P.C., Morris, H.P.: Chromosomes of “minimal deviation” hepatomas: A further report on diploid tumors. Cancer Res. 29, 969–970 (1969).

    Google Scholar 

  • Norwell, P.C., Morris, H.P., Potter, V.R.: Chromosomes of “minimal derivation” hepatomas and some other transplantable rat tumors. Cancer Res. 27, 1565–1579 (1967).

    Google Scholar 

  • Novick, A., Sparrow, A. H.: The effects of nitrogen mustard on mitosis in onion root tips. J. Hered. 40, 13–17 (1949).

    PubMed  CAS  Google Scholar 

  • Ohno, S., Trujillo, J.M., Kaplan, W.D., Kinosita, R., Stenius, S.: Nucleolus organizers in the causation of chromosomal anomalies in man. Lancet 1961 2, 123–125.

    Article  PubMed  CAS  Google Scholar 

  • Okada, Y.: Analysis of giant polynuclear cell formation caused by HVJ virus from Ehrlich ascites tumor cells. I. Microscopic observation of giant polynuclear cell formation. Exp. Cell Res. 26, 98–107 (1962).

    Article  PubMed  CAS  Google Scholar 

  • Patterson, E. K., Podber, E.: Aminopeptidase content as correlated with chromosome constitutions in sublines of the Ehrlich ascites tumor. Ann. N.Y. Acad. Sci. 63, 988–997 (1956).

    Article  PubMed  CAS  Google Scholar 

  • Potter, M., Law, L.W.: Studies of a plasma cell neoplasm of the mouse. 1. Characterization of neoplasm 70429, including its sensitivity to various antimetabolities with the rapid development of resistance to azaserine, DON and N-methylformamide. J. nat. Cancer Inst. 18, 413–440 (1957).

    PubMed  CAS  Google Scholar 

  • Rabotti, G.: Ploidy of primary and metastatic human tumors. Nature (Lond.) 183, 1276–1277 (1959).

    Article  CAS  Google Scholar 

  • Rees, E. D., Majumdar, S. K., Shuck, A.: Changes in chromosomes of bone marrow after intravenous injections of 7,12-dimethylbenz(a)anthracene and related compounds. Proc. nat. Acad. Sci. (Wash.) 66, 1228–1235 (1970).

    Article  CAS  Google Scholar 

  • Rich, M. A., Tsuchida, R., Siegler, R.: Chromosome aberrations: Their role in the etiology of murine leukemia. Science 146, 252–253 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Rothfels, K.H., Axelard, A.A., Siminovitch, L., McCulloch, E.A., Parker, R.C.: The origin of altered cell lines from mouse, monkey, and man, as indicated by chromosome and transplantation studies. Canad. Cane. Conf. 3, 189–213 (1959).

    Google Scholar 

  • Rothfels, K. H., Kuppel wieser, E. B., Parker, R. C.: Effects of X-irradiated feeder layers on mitotic activity and development of aneuploidy in mouse-embryo cells in vitro. Canad. Cane. Conf. 5, 191–223 (1963).

    CAS  Google Scholar 

  • Rothfels, K.H., Parker, R. C.: The karyotypes of cell lines recently established from normal mouse tissues. J. exptl. Zool. 142, 507–520 (1959).

    Article  CAS  Google Scholar 

  • Rothfels, K. H., Siminovich, L.: An air-drying technique for flattening chromosomes in mammalian cells grown in vitro. Stain Technol. 33, 73–77 (1958).

    PubMed  CAS  Google Scholar 

  • Sachs, L.: Polyploid evolution and mammalian chromosomes. Heredity 6, 357–364 (1952).

    Article  Google Scholar 

  • Sachs, L., Gallily, R.: The chromosomes and transplantability of tumors. I. Fundamental chromosome number and strain specificity in ascites tumors. J. nat. Cancer Inst. 15, 1267–1280 (1955).

    PubMed  CAS  Google Scholar 

  • Sakai, T.: Chromosome studies on a transplantable granulocytic leukemia (chloroleukemia) of rat. Acta haemat. jap. 33, 402–414 (1970).

    PubMed  CAS  Google Scholar 

  • Sakai, T.: Karyotype shift of transplantable rat chloroma (Shay). Acta haemat. jap. 34, 604–613 (1971).

    PubMed  CAS  Google Scholar 

  • Sakai, T., Yosida, T.H.: Chromosome alteration in a transplantable rat chloroleukemia and its meaning. La Kromosomo 85–86, 2748 (1971).

    Google Scholar 

  • Sakai, T., Yosida, T.H., Shimizu, M.: Alteration of karyotype in a transplantable granulocytic leukemia (chloroleukemia) in the rat. Ann. Rep. Nat. Inst. Genet. Japan 16, 51 (1966).

    Google Scholar 

  • Saksela, E., Moorhead, P.S.: Aneuploidy in the degenerative phase of serial cultivation of human cell strains. Proc. nat. Acad. Sci. (Wash.) 50, 390–395 (1963).

    Article  CAS  Google Scholar 

  • Sasaki, M.: Cytological studies of tumors. XXIV. An azo-dye induced ascites hepatoma of the rat, with special remarks on transitional changes of neoplastic characters in the course of serial transfers. Gann 49, 331–340 (1958).

    CAS  Google Scholar 

  • Sato, J.: Malignant transformation in culture of rat liver cells treated with and without 3-methyl-4- dimethylaminoazobenzene. In: Cancer Cells in Culture, Ed. H. Katsuta, p. 335–350. Tokyo: Univ. Tokyo Press 1968.

    Google Scholar 

  • Schmidtke, C.: Über die Anwendung von hypotonischen Lösungen bei der Darstellung von Säugetierchromosomen. Z. Tier.-Züchtungsbiol. 64, 381–388 (1955).

    Article  Google Scholar 

  • Schrecker, A.W., Venditti, J.M., Greenberg, N.H., Biedler, J.L., Robinson, D.L., Hutchison, D. J.: Association in increased dihydrofolate reductase level and chromosome alteration in ametho- pterin-resistant sublines of leukemia L1210. J. nat. Cancer Inst. 31, 557–574 (1963).

    PubMed  CAS  Google Scholar 

  • Sofuni, T., Makino, S., Kobayashi, H.: A study of chromosomes in Friend virus-induced mouse leukemias. Proc. Jap. Acad. 43, 389–394 (1967).

    Google Scholar 

  • Stich, H.F.: Das Vorkommen von Ribonucleinsäure in Kernsaft und Spindel sich teilender Kerne von Cyclops Strenuus. Z. Naturforsch. 6b, 259–261 (1951).

    Google Scholar 

  • Stich, H. F.: Chromosomes of tumor cells. I. Murine leukemias induced by one or two injections of 7,12-dimethylbenz(a)anthracene. J. nat. Cancer Inst. 25, 649–661 (1960a).

    CAS  Google Scholar 

  • Stich, H.F.: The DNA content of tumor cells. II. Alterations during the formation of hepatomas in rats. J. nat. Cancer Inst. 24, 1283–1297 (1960b).

    PubMed  CAS  Google Scholar 

  • Stich, H.F., Wakonig, R., Axelrad, A.A.: Chromosome complement of spontaneous leukemia in AKR mice. Nature (Lond.) 184, 998–999 (1959).

    Article  Google Scholar 

  • Stich, H. F., Van Hoosier, G. L., Trentin, J. J.: Viruses and chromosomes: Chromosome aberrations by human adenovirus type 12. Exp. Cell. Res. 34, 400–403 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Stone, D., Kang, Y.S.: Differences in chromosome stem-lines of a strain of HeLa cells inhibited in growth by certain steroids, and of steroid-resistant sub-lines selected from the sensitive strain. Endocrinology 71, 238–243 (1962).

    Article  PubMed  CAS  Google Scholar 

  • Sugiyama, T.: Specific vulnerability of the largest telocentric chromosome of rat bone marrow cells to 7,12-dimethylbenz(a)anthracene. J. nat. Cancer Inst. 47, 1267–1275 (1971).

    PubMed  CAS  Google Scholar 

  • Sugiyama, T., Kurita, Y., Nishizuka, Y.: Chromosome abnormality in rat leukemia induced by 7,12-dimethylbenz(a)anthracene. Science 158, 1058–1059 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Sugiyama, T., Kurita, Y., Nishizuka, Y.: Biologic studies on 7,12-dimethylbenz(a)anthracene- induced rat leukemia with special reference to the specific chromosomal abnormalities. Cancer Res. 29, 1117–1124(1969).

    PubMed  CAS  Google Scholar 

  • Takeda, K., Aizawa, M., Imamura, T., Sasage, S., Matsumoto, K., Kanehira, S.: On the nature of a new ascites tumor of rat (Takeda) and its relation to ascites sarcoma of Yoshida, MTK 1–2 and Hirosaki types. Gann 43, 132–135 (1952).

    CAS  Google Scholar 

  • Takeda, K., Imamura, T., Yoshio, M., Aizawa, M., Ishikura, H., Usubuchi, I., Watanabe, S., Motoyama, T.: Studies on the inhibiting factors to Yoshida sarcoma in several animals sensitized with organs of several strains of rats. Gann 41, 98–100 (1950).

    PubMed  CAS  Google Scholar 

  • Takeda, K., Nakamura, K., Mori, S., Kumagai, H., Shimizu, K., Ikeda, K.: Studies on Yoshida sarcoma during successive transplantation in several strains of rats, with special reference to benign and malignant alterations of tumor. Gann 40, 120–124 (1949).

    Google Scholar 

  • Tanaka, T.: A simple squash technique applicable to the chromosomes of mammalian tissue and tumor cells. Gann 42, 81–85 (1951).

    PubMed  CAS  Google Scholar 

  • Tanaka, T., Kano, K.: Cytological studies on cancer. IV. General characters of the MTK-sarcomas, new ascites tumors of rats produced by the administration of azo-dye. J. Fac. Sci. Hokkaido Univ. Ser. VI. Zool. 10, 289–301 (1951).

    Google Scholar 

  • Tanaka, T., Kano, K.: On the somatic chromosomes of rats. Cytologia Suppl. (Proc. Intern. Genet. Symp., Tokyo, 1956): 196–201 (1957).

    Google Scholar 

  • Thomas, P.T.: Experimental imitation of tumor conditions. Nature (Lond.) 156, 738–740 (1945).

    Article  CAS  Google Scholar 

  • Timonen, S., Therman, E.: The changes in the mitotic mechanism of human cancer cells. Cancer Res. 10, 431–439 (1950).

    PubMed  CAS  Google Scholar 

  • Tjio, J.H., Levan, A.: Chromosome analysis of three hyperdiploid ascites tumors of the mouse. Lund Univ. Arsskrift N.F. Avd. 2, 50, 3–38 (1954a).

    Google Scholar 

  • Tjio, J.H., Levan, A.: Some experiences with acetic orcein in animal chromosomes. Ann. Esta. Exp. de Aula Dei 3, 225–228 (1954b).

    Google Scholar 

  • Tjio, J.H., Levan, A.: Comparative idiogram analysis of the rat and the Yoshida rat sarcoma. Hereditas 42, 218–234 (1956).

    Article  Google Scholar 

  • Tjio, J.H., Puck, T.T.: Genetics of somatic mammalian cells II. Chromosomal constitution of cells in tissue culture. J. exp. Med. 108, 259–268 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Tonomura, A.: Individuality of chromosomes in the tumor stem cells of the MTK-sarcoma II after transformation into the subcutaneous solid form. Zool. Mag. (Tokyo) 62, 411–415 (1953).

    Google Scholar 

  • Tonomura, A.: Cytological studies of tumors. XVI. Cytological differences of MTK-sarcoma II and Takeda sarcoma, with preliminary experiments on double inoculation with the two tumors. J. Fac. Sci. Hokkaido Univ. Ser. VI. Zool. 12, 158–168 (1954).

    Google Scholar 

  • Tonomura, A., Sasaki, M.: Cytological studies of tumors XIX. A chromosome survey of the MTK- sarcoma II and III after several years of serial transfers. J. Fac. Sci. Hokkaido Univ. Ser. VI. Zool. 13, 332–337 (1957).

    Google Scholar 

  • Trambusti, A.: Über den Bau und Theilung der Sarkomzellen: Cytologische Untersuchungen. Beitr. Z. path. u. Z. allg. Path. 22, 88–104 (1897).

    Google Scholar 

  • Tsuchida, R., Rich, M.A.: Chromosomal aberrations in viral leukemogenesis. 1. Friend and Rauscher leukemia. J. nat. Cancer Inst. 33, 33–47 (1964).

    PubMed  CAS  Google Scholar 

  • Tsukada, H., Fu, S.C.J.: Correlation between malignancy and respiratory metabolism of three sublines of Ehrlich ascites tumor cells. Proc. Amer. Ass. Cancer Res. 3, 70 (1959).

    Google Scholar 

  • Tsukada, H., Fu, S.C.J., Kato, R., Yerganian, G.: A new subline of Ehrlich ascites tumor: Hypertriploid. Cytologia 26, 419–422 (1961).

    Article  Google Scholar 

  • Umetani, M.: General cytological characteristics of the MTK-sarcoma III, a new ascites tumor of white rats artificially produced. Zool. Mag. (Tokyo) 62, 416–420 (1953).

    Google Scholar 

  • Usubuchi, I., Iida, T., Abe, H., Koseki, T., Kosugi, S.: A new strain of ascites sarcoma (Hirosaki- strain) similar to the Yoshida sarcoma. Gann 44, 130–132 (1953).

    Google Scholar 

  • Virchow, R.: Die endogene Zellenbildung beim Krebs. Virchows Arch. path. Anat. 3, 197–227 (1851).

    Article  Google Scholar 

  • Vogt, M., Dulbecco, R.: Steps in the neoplastic transformation of hamster embryo cells by polyoma virus. Proc. nat. Acad. Sci. (Wash.) 49, 171–179 (1963).

    Article  CAS  Google Scholar 

  • Wahrman, J., Zahavi, A.: Cytological contributions to the phylogeny and classification of the rodent genus Gerbillius. Nature (Lond.) 175, 600–602 (1955).

    Article  Google Scholar 

  • Wakonig-Vaartaja, R.: Chromosomes in leukemias induced by S37 and Friend viruses. Brit. J. Cancer 15, 120–122 (1961).

    Article  PubMed  CAS  Google Scholar 

  • Wakonig, R., Stich, H.F.: Chromosomes in primary and transplanted leukemias of AKR mice. J. nat. Cancer Inst. 25, 295–305 (1960).

    Google Scholar 

  • Winge, O.: Zytologische Untersuchungen über die Natur maligner Tumoren; II. Teerkarzinome bei Mäusen. Z. wiss. Biol. B. Z. Zellforsch. 10, 683–735 (1930).

    Article  Google Scholar 

  • Yoshida, T.: Studien über das Ascites Hepatom. Zugleich ein Beitrag zum Begriff der cellulären Autonomie im Wachstum der malignen Geschwulst einerseits, und der Individualität der einzelnen Geschwulst andererseits. Virchows Arch. path. Anat. 33, 85–105 (1957).

    Article  Google Scholar 

  • Yoshida, T., Sasaki, J., Muta, Y.: Studien über das “Ascites-Sarcoma”. Proc. imp. Acad. Tokyo 20, 611–616(1944).

    Google Scholar 

  • Yosida, T. H.: A preliminary note on the karyological study of Yoshida ascites sarcoma in the white rat. Oguma Comm. Vol. Cyt. Genet. 1, 130–132 (1948).

    Google Scholar 

  • Yosida, T.H.: Abnormalities in dividing tumor cells and their frequencies in the Yoshida sarcoma. (Preliminary notes on the karyological study in tumors. No. 2). Jap. J. Genet. Suppl. 2. 137–145 (1949a).

    Google Scholar 

  • Yosida, T. H.: A comparative study on the behaviour of tumor cells in two strains of white rats which show different reactions for the Yoshida sarcoma. (Preliminary notes on the karyological study in tumors, No. 3). Jap. J. Genet. Suppl. 2, 146–154 (1949b).

    Google Scholar 

  • Yosida, T. H.: Cytological studies on the effect of colchicine and nitrogen-mustard upon tumor cells of the Yoshida sarcoma. Pap. Coord. Committ. Res. Genet. 3, 199–204 (1952 a).

    Google Scholar 

  • Yosida, T.H.: Cytological studies on cancer, VI. Spontaneous tumors occurring in inbred mice, with notes on the establishment of two new strains of transplantable tumor. J. Fac. Sci. Hokkaido Univ. Ser. VI. Zool. 11, 41–50 (1952b).

    Google Scholar 

  • Yosida, T. H.: Karyological study on the tumor cells of the Ehrlich ascites carcinoma in mouse. Ann. Rep. nat. Inst. Genet. Japan 3, 15–17 (1953 a).

    Google Scholar 

  • Yosida, T. H.: Karyological study on the tumor cells of Takeda sarcoma in the rat. Ann. Rep. nat. Inst. Genet. Japan 3, 10–12 (1953b).

    Google Scholar 

  • Yosida, T. H.: Karyological study on the tetraploid tumors in the rat and the mouse. Gann 44, 142–144 (1953c).

    Google Scholar 

  • Yosida, T.H.: Karyological study on cells of the “quinone carcinoma” in mouse. Ann. Rep. nat. Inst. Genet. Japan 3, 12–15 (1953d).

    Google Scholar 

  • Yosida, T. H.: Karyological studies of the Takizawa quinon-carcinoma and the Ehrlich ascites carcinoma in mice. Cytologia 19, 225–238 (1954a).

    Article  Google Scholar 

  • Yosida, T. H.: Tetraploid chromosome constitution characteristic of the tumor cells of the Takeda sarcoma. Gann 45, 9–15 (1954b).

    CAS  Google Scholar 

  • Yosida, T.H.: A simple squash technique for observation of chromosome structures in normal somatic and malignant tumor cells. Ann. Rep. nat. Inst. Genet. Japan 5, 17–18 (1955 a).

    Google Scholar 

  • Yosida, T. H.: Origin of V-shaped chromosomes occurring in tumor cells of some ascites sarcomas in the rat. Proc. Jap. Acad. 31, 237–242 (1955b).

    Google Scholar 

  • Yosida, T. H.: Origin of V-shaped chromosomes occurring in tumor cells and their significance for tumor growth. Cytologia Suppl. Vol. (Proc. Intern. Genet. Sump., 1956):210–215 (1957).

    Google Scholar 

  • Yosida, T. H.: Ion concentrations in relation to the spreading and splitting of the chromosomes at metaphase. Symp. Cell Chem. (Tokyo) 7, 91–100 (1958).

    Google Scholar 

  • Yosida, T. H.: Chromosomal alteration and the development of tumors. I. A new subline of Yoshida sarcoma developed by chromosomal mutation. Z. Krebsforsch. 63, 209–214 (1959 a).

    Article  PubMed  CAS  Google Scholar 

  • Yosida, T. H.: Chromosomal alteration and the development of tumors. II. Chromosome conditions and invasiveness of the Yoshida sarcoma cells. Gann 50, 233–238 (1959 b).

    PubMed  CAS  Google Scholar 

  • Yosida, T.H.: Chromosomal alteration and the development of tumors. V. Temporary proliferation of tetraploid cells in the Yoshida sarcoma and their origin. Gann 51, 359–369 (1960).

    PubMed  CAS  Google Scholar 

  • Yosida, T. H.: Chromosomal alteration and the development of tumors. VIII. Affinity of diploid and polyploid tumor cells of common Yoshida sarcoma strains to certain organs. Gann 52, 313–320(1961).

    PubMed  CAS  Google Scholar 

  • Yosida, T. H.: Chromosomal alteration and the development of tumors. IX. Increase in the frequency of polyploid cells in metastatic tumors of the Ehrlich hyperdiploid tumor of mice. Jap. J. Genet. 38, 342–350 (1964).

    Article  Google Scholar 

  • Yosida, T. H.: Relation between chromosomal alteration and development of tumors. Jap. J. Genet. 41,439–451 (1966a).

    Article  Google Scholar 

  • Yosida, T. H.: Chromosomal alteration and the development of tumors. XIV. Comparative idiogram analysis of several sublines of mouse lymphocytic neoplasm, P388, growing in vivo and in vitro. Jap. J. Genet. 41, 43–58 (1966b).

    Article  Google Scholar 

  • Yosida, T. H.: Chromosomal alteration and the development of tumors. XV. Change of chromosome pattern in 8-azaguanine and amethopterin resistant sublines of the mouse lymphocytic neoplasm, P388, cultured in vitro. Jap. J. Genet. 41, 59–74 (1966c).

    Article  Google Scholar 

  • Yosida, T.H.: Relationship between chromosomal alteration and development of tumors in vivo and in vitro. In: Cancer Cell in Culture, Ed. H. Katsuta, p. 171–194. Tokyo: Univ. Tokyo Press 1968.

    Google Scholar 

  • Yosida, T.H.: Is aging of tumor cells related to the alteration of stemline karyotypes? Proc. Jap. Acad. 48, 268–273 (1972).

    Google Scholar 

  • Yosida, T. H.: Chromosome alteration in the course of serial transplantation of experimental tumors and aging of tumor stemline cells. Ree. Result Cancer Res. 44, 86–93 (1974).

    Google Scholar 

  • Yosida, T.H., Amano, K.: Autosomal polymorphism in laboratory bred and wild Norway rats, Rattus norvegicus, found in Misima. Chromosoma (Berl.) 16, 658–667 (1965).

    CAS  Google Scholar 

  • Yosida, T.H., Hirumi, H.: Cytological study on the effects of 8-azaguanin and related compounds on the Yoshida sarcoma cells. Gann 51, 345–357 (1960).

    PubMed  CAS  Google Scholar 

  • Yosida, T.H., Imai, H., Moriwaki, K.: Chromosomal alteration and development of tumors. XXI. Cytogenetic studies of primary plasma-cell neoplasms induced in BALB/c mice. J. nat. Cancer Inst. 45,411–418 (1970).

    PubMed  CAS  Google Scholar 

  • Yosida, T.H.: Imai, H.T., Potter, M.: Chromosomal alteration and development of tumors. XIX. Chromosome constitution of tumor cells in 16 plasma cell neoplasms of BALB/c mice. J. nat. Cancer Inst. 41, 1083–1097 (1968).

    PubMed  CAS  Google Scholar 

  • Yosida, T.H., Imai, H., Sato, H.: Chromosomal alteration and the development of tumors. XII. Differentiation of karyotypes in mouse ascites hepatomas MH-134 and MH-129P maintained in different locations. Gann 57, 9–17 (1966).

    PubMed  CAS  Google Scholar 

  • Yosida, T.H., Ishihara, T.: Karyological observation on a hepatoma developed in the white rat. Ann. Rep. nat. Inst. Genet. Japan 6, 22–23 (1956).

    Google Scholar 

  • Yosida, T.H., Ishihara, T., Hamada, T.: Chromosomal alteration and the development of tumors. III. Change in ploidy of the stemline chromosomes in a mouse sarcoma in connection with a transplantability shift. Gann 51, 55–65 (1960).

    PubMed  CAS  Google Scholar 

  • Yosida, T.H., Kurita, Y., Moriwaki, K.: Chromosomal alterations induced in Yoshida sarcoma cells by 4-nitroquinoline 1-oxide. Gann 56, 523–528 (1965).

    PubMed  CAS  Google Scholar 

  • Yosida, T.H., Kurita, Y., Moriwaki, K.: Chromosomal alteration and the development of tumors. XIII. Karyotypic difference in solid and ascites type tumors of mouse plasma cell neoplasm X5563, with special regard to the serum electrophoretic pattern of gamma globulin. Jap. J. Genet. 41,9–15 (1966).

    Article  Google Scholar 

  • Yosida, T.H., Kuroki, T., Masuji, H., Sato, H.: Chromosomal alteration and the development of tumors. XX. Chromosome change in the course of malignant transformation in vitro of hamster embryonic cells by 4-nitroquinoline 1-oxide and its derivative, 4-hydroxyaminoquinoline 1-oxide. Gann 61, 131–143 (1970).

    PubMed  CAS  Google Scholar 

  • Yosida, T.H., Law, L.W.: Further study on chromosomes of leukemias in the mouse induced with Moloney leukemia virus (MLV). Ann. Rep. nat. Inst. Genet. Japan 15, 57 (1965).

    Google Scholar 

  • Yosida, T. H., Law, L. W.: Chromosomal alteration and the development of tumors. XVII. Chromosomes of the mouse leukemias induced by Moloney leukemogenic virus (MLV) infection. Cytologia 33, 256–268 (1968).

    Article  Google Scholar 

  • Yosida, T.H., Law, L.W., Precerutti, A.: Karyological study on mouse leukemias developed by virus infection. Ann. Rep. nat. Inst. Genet. Japan 14, 41–42 (1964).

    Google Scholar 

  • Yosida, T.H., Makino, S.: Breeding experiments of white rats and mice. IV. Misol. Yamashina’s Inst. Orinith. and Zool. 5, 185–193 (1954).

    Google Scholar 

  • Yosida, T.H., Matano, Y., Inui, N., Kamioka, T.: Chromosomal alteration and development of tumors. XI. Karyological observations on the Misima subline of hyperdiploid Ehrlich tumor and its three clones. Cytologia 29, 359–369 (1964).

    Article  Google Scholar 

  • Yosida, T.H., Ogawa, Y.: Utility of various concentration of chloride solutions for chromosome study. Ami. Rep. nat. Inst. Genet. Japan 6, 20–21 (1956).

    Google Scholar 

  • Yosida, T.H., Ohara, K. Law, L.W.: Chromosomal alteration and the development of tumors. XVI. Karyological studies on sensitive and resistant sublines of the mouse lymphocytic leukemia, L-1210, to several antitumor agents. Jap. J. Genet. 42, 339–347 (1967).

    Article  Google Scholar 

  • Yosida, T.H., Ohara, H., Roosa, R.A.: Chromosomal alteration and the development of tumors. XVIII. Karyotypes of a 5-fluorodeoxyuridine resistant subline in the mouse lymphocytic leukemia, P388, growing in vitro. Jap. J. Genet. 43, 49–56 (1968).

    Article  Google Scholar 

  • Yosida, T.H., Potter, M., Kurita, Y., Moriwaki, K.: Relation between chromosome constitution and protein specificity in mouse plasma cell leukemias. Ann. Rep. nat. Inst. Genet. Japan 14, 42 (1964).

    Google Scholar 

  • Yosida, T.H., Tsuji, S.: Chromosomal alteration and the development of tumors. VI. Difference in invasiveness of the diplo- and tetraploid cells of the Yoshida sarcoma. Jap. J. Genet. 35, 377–381 (1960).

    Article  Google Scholar 

  • Yosida, T.H., Tsuruta, R., Kurita, Y.: Comparative study of mouse leukemias developed by treatment with chemicals and radiation. Ann. Rep. nat. Inst. Genet. Japan 17, 15–16 (1967).

    Google Scholar 

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Yosida, T.H. (1975). Chromosomal Alterations and Development of Experimental Tumors. In: Grundmann, E. (eds) Geschwülste · Tumors II. Handbuch der allgemeinen Pathologie, vol 6 / 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80853-1_9

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