Pharmacodynamic Mechanism in Carcinogenesis

  • W. Nakahara
Part of the Handbuch der allgemeinen Pathologie book series (PATHOLOGIE, volume 6 / 6)

Abstract

Investigation of the mechanism of carcinogenesis has now come to include interaction between carcinogenic molecules and competent biologic molecules of cellular components, involving quantum biological, organic chemical, and enzymatic reactions. Changes in cell behavior have been observed after the successful transformation of normal cells to malignant cells in tissue culture. The entire problem, moreover, is at a major turning point, on account of the increasing impact of recent studies on so-called oncogenic viruses. None of these attempts to determine the carcinogenic mechanism has as yet yielded any final conclusion that is applicable to all types of carcinogens and is unconditionally acceptable. However, we can use experimental results on the pharmacodynamic action of carcinogens to formulate a system of thought on the nature of the carcinogenic mechanism.

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References

  1. Ahlstrom, C.G., Andrewes, C.N.: Fibroma virus infection in tarred rabbits. J. Path. Bact. 47, 65–86 (1938).Google Scholar
  2. Albert, R.E., Newman, W., Altschuler, B.: The dose-response relationship of beta-ray-induced skin tumours in the rat. Radiol. Rev. 15, 410–430 (1961).Google Scholar
  3. Andervont, H.B., Dunn, T.B.: Responses of strain DBA/2 mice, without the mammary tumor agent, to oral administration of methylcholanthrene. J. nat. Cancer Inst. 14, 329–339 (1953).PubMedGoogle Scholar
  4. Baba, T., Aoki, K., Ishii, M.: Relation between the so-called two-phase theory and summation theory in carcinogenesis. Gann 58, 161–166 (1967).PubMedGoogle Scholar
  5. Backmann, W.E., Kennaway, E.L., Kennaway, N.M.: Rapid production of tumours by two new hydrocarbons. Yale J. Biol. Med. 11, 97–102 (1938).Google Scholar
  6. Barry, G., Cook, J.W., Haslewood, G.A., Hewett, C.L., Hieger, I., Kennaway, E.L.: Production of cancer by pure hydrocarbons. III. Proc. roy. Soc. B 117, 318–351 (1935).Google Scholar
  7. Bauer, K.H.: Das Krebsproblem, 1st ed. Berlin-New York-Heidelberg: Springer 1948.Google Scholar
  8. Berenblum, I.: The cocarcinogenic action of croton resin. Cancer Res. 1, 44–48 (1941).Google Scholar
  9. Berenblum, I.: The mechanism of carcinogenesis. A study of the significance of cocarcinogenic action and related phenomena. Cancer Res. 1, 807–814 (1941).Google Scholar
  10. Berenblum, I.: Carcinogenesis and tumor pathogenesis. Advanc. Cancer Res. 2, 129–176 (1954).Google Scholar
  11. Berenblum, I., Haran-Ghera, N.: A quantitative study of the systemic initiating action of urethane (ethylcarbamate) in mouse skin carcinogenesis. Brit. J. Cancer 11, 77–84 (1957).PubMedGoogle Scholar
  12. Berenblum, I., Shubik, P.: The persistence of latent tumor cells induced in the mouse’s skin by a single application of 9:10-dimethyl-l,2-benzanthracene. Brit. J. Cancer 3, 384–386 (1949).PubMedGoogle Scholar
  13. Bielschowsky, F.: Distant tumors produced by 2-amino- and 2-acetylaminofluorene. Brit. J. exp. Path. 25, 1–4 (1944).Google Scholar
  14. Bielschowsky, F.: The carcinogenic action. The role of thyroxine deficiency in the formation of experimental tumours of the thyroid. Brit. J. Cancer 3, 547–549 (1949).PubMedGoogle Scholar
  15. Bielschowsky, F., Hall, W.H.: Carcinogenesis in parabiotic rats: Tumors of liver and seminal vesicle induced by acetylaminoflorene in normal males joined to castrated males or females. Brit. J. Cancer 5, 106–114 (1951).PubMedGoogle Scholar
  16. Blum, H.F.: Environmental radiation and cancer. Science 130, 1545–1547 (1959).PubMedGoogle Scholar
  17. Blum, H.F., Grady, H.G., Kirby-Smith, J.S.: Relationship between dosage and rate of tumor induction by ultraviolet radiation. J. nat. Cancer Inst. 3, 91–97 (1942).Google Scholar
  18. Blum, N.F.: Carcinogenesis by ultraviolet light. Princeton: University Press 1959.Google Scholar
  19. Boutwell, R.K., Bosch, D.K.: The carcinogenicity of croton oil; its role in the induction of skin tumors in mice. Cancer Res. 18, 1171–1175 (1958).PubMedGoogle Scholar
  20. Bryan, W.R., Shimkin, M.B.: Quantitative analysis of dose response data obtained with three different carcinogenic hydrocarbons in strain C3H male mice. J. nat. Cancer Inst. 1, 807–833 (1943).Google Scholar
  21. Burnet, F.M.: The concept of immunological surveillance. Progr. exp. Tumor Res. (Basel) 13, 1–15 (1970).Google Scholar
  22. Carr, J.C.: The effect of some substances influencing cell activity on the growth of the Rous No. 1 sarcoma. Brit. J. exp. Path. 23, 221–228 (1942).Google Scholar
  23. Casarett, G.W.: Experimental radiation carcinogenesis. Progr. exp. Tumor Res. (Basel) 7, 49–82 (1965).Google Scholar
  24. Clapp, N.K., Craig, A.W.: Carcinogenic effect of diethylnitrosamine in RF mice. J. nat. Cancer Inst. 39, 903–916 (1967).PubMedGoogle Scholar
  25. Clapp, N.K., Craig, A.W., Toya, R.E.: Pulmonary and hepatic oncogenesis during treatment of male RF mice with dimethylnitrosamine. J. nat. Cancer Inst. 41, 1213–1227 (1968).PubMedGoogle Scholar
  26. Clayson, D.B.: Incomplete carcinogens and two-stage theory of carcinogenesis. In: Chemical carcinogenesis, p. 290–314. Boston: Little-Brown 1962.Google Scholar
  27. Cook, J.W., Hewett, C.L.: The isolation of cancer-producing hydrocarbons from coal tar. III. Synthesis of 1:2- and 4:5-benzpyrene. J. chem. Soc. 398–403 (1933).Google Scholar
  28. Cook, J.W., Hieger, I., Kennaway, E.L., Mayneord, W.V.: Production of cancer by pure hydrocarbons. Proc. roy. Soc. B 111, 455–484 (1932).Google Scholar
  29. Crabtree, H.G.: Influence of unsaturated dibasic acids on the induction of skin tumors by chemical carcinogens. Cancer Res. 5, 346–351 (1945).Google Scholar
  30. Cramer, J.W., Miller, J. A., Miller, E.C.: The hydroxylation of the carcinogen 2-acetylaminofluorene by rat liver: Stimulation by pretreatment in vivo with 3-methylcholanthrene. J. biol. Chem. 235, 250–256 (1960).PubMedGoogle Scholar
  31. Cramer, W., Stowell, R.E.: On the quantitative evaluation of experimental skin carcinogenesis by methylcholanthrene. The factors of dosage, time, spacing applications and the multiplicity of the carcinogenic response. Cancer Res. 3, 668–681 (1943).Google Scholar
  32. Dao, T.L.: Carcinogenesis of mammary gland in rat. Progr. exp. Tumor Res. (Basel) 5, 157–216 (1964).Google Scholar
  33. Dao, T.L.: Inhibition of tumor induction in chemical carcinogenesis in the mammary gland. Progr. exp. Tumor Res. (Basel) 14, 59–88 (1971).Google Scholar
  34. Dao, T.L., Bock, F.G., Crouch, S.: Level of 3-methylcholanthrene in mammary glands of rats after intragastric instillation of carcinogen. Proc. Soc. exp. Biol. (N.Y.) 102, 635–638 (1959).Google Scholar
  35. Dao, T.L., Bock, F.G., Greiner, M.J.: Mammary carcinogenesis by 3-methylcholanthrene. II. J. nat. Cancer Inst. 25, 991–1003 (1960).PubMedGoogle Scholar
  36. Dao, T.L., Sunderland, H.: Mammary carcinogenesis by 3-methylcholanthrene. I. Hormonal aspects in tumor induction and growth. J. nat. Cancer Inst. 23, 567–583 (1959).PubMedGoogle Scholar
  37. Deelman, H.T. van Erp, J.P.: Beobachtungen am experimentellen Tumorwachstum. Z. Krebsforsch. 24, 86–97 (1927).Google Scholar
  38. Dontenwill, W., Mohr, U.: Experimentelle Untersuchungen zum Problem der Carcinomentstehung im Respirationstrakt. II. Die Wirkung von Tabakrauchkondensaten und Zigarettenrauch auf die Lunge des Goldhamsters. Z. Krebsforsch. 65, 62–68 (1962).PubMedGoogle Scholar
  39. Dontenwill, W., Reckzeh, G., Stadler, L.: Inhalationsexperimente mit Zigarettenrauch. Beitr. Tabakforsch. 3, 438–448 (1966).Google Scholar
  40. Druckrey, H.: Experimentelle Beiträge zum Mechanismus der carcinogenen Wirkung. Arzneimittel-Forsch. 1, 382–391 (1951).Google Scholar
  41. Druckrey, H.: Beiträge zum Mechanismus der Carcinogenese. Acta Un. int. Cancer. 10, 29–43 (1954).Google Scholar
  42. Druckrey, H.: Pharmacological approach to carcinogenesis. Ciba Found. Sympos. Carcinogenesis, p. 110–127 (1959).Google Scholar
  43. Druckrey, H.: Experimental investigations on the possible carcinogenic effects of tobacco smoking. Acta med. scand. 170, 24–42 (1961).Google Scholar
  44. Druckrey, H.: Quantitative aspects in chemical carcinogenesis. U.I.C.C. Monograph Ser. 7, 60–67 (1967).Google Scholar
  45. Druckrey, H.: Chloriertes Trinkwasser, Toxizitäts-Prüfungen an Ratten über sieben Generationen. Fed. Cosmet. Toxicol. 6, 147–152 (1968).Google Scholar
  46. Druckrey, H., Ivankovic, S., Mennel, H.D., Preussmann, R.: Selektive Erzeugung von Carcinomen der Nasenhöhle bei Ratten durch N, N’-Di-Nitrosopiperazin, Nitrosopiperidin, Nitrosomorpholin, Methylallyl-, Dimethyl- und Methyl-vinyl-nitrosamin. Z. Krebsforsch. 66, 138–150 (1964).PubMedGoogle Scholar
  47. Druckrey, H., Ivankovic, S., Preussmann, R.: Selektive Erzeugung von Hirntumoren bei Ratten durch Methylnitrosoharnstoff. Naturwissenschaften 51, 144 (1964).Google Scholar
  48. Druckrey, H., Ivankovic, S., Preussmann, R.: Selektive Erzeugung maligner Tumoren in Gehirn und Rückenmark von Ratten durch N-Methyl-N-Nitrosoharnstoff. Z. Krebsforsch. 66, 389–408 (1965).PubMedGoogle Scholar
  49. Druckrey, H., Küpfmüller, K.: Quantitative Analyse der Krebsentstehung. Z. Naturforsch. 3b, 254–266 (1948).Google Scholar
  50. Druckrey, H., Preussmann, R.: Erzeugung von Lungenkrebs durch subcutane Injektion von N, N-Dimethylnitrosamin an Ratten. Naturwissenschaften 49, 111–112 (1962).Google Scholar
  51. Druckrey, H., Preussmann, R.: Zur Entstehung carcinogener Nitrosamine am Beispiel des Tabakrauchs. Naturwissenschaften 49, 498–499 (1962).Google Scholar
  52. Druckrey, H., Preussmann, R., Ivankovic, S., Schmähl, D.: Organotrope carcinogene Wirkungen bei 65 verschiedenen N-Nitroso-Verbindungen an BD-Ratten. Z. Krebsforsch. 96,103–201 (1967).Google Scholar
  53. Druckrey, H., Preussmann, R., Ivankovic, S., Schmidt, C.H., Mannel, H.D., Stahl, K.W.: Selektive Erzeugung von Blasenkrebs an Ratten durch Dibutyl- und N-Butyl-N-butanol-(4)-nitrosamin. Z. Krebsforsch. 66, 280–290 (1964).PubMedGoogle Scholar
  54. Druckrey, H., Preussmann, R., Schmähl, D.: Carcinogenicity and chemical structure of nitrosamines. Acta Un. int. Cancr. 19, 512–519 (1963).Google Scholar
  55. Druckrey, H., Schildbach, A.: Quantitative Untersuchungen zur Bedeutung des Benzpyrenes für die carcinogene Wirkung von Tabakrauch. Z. Krebsforsch. 65, 465–470 (1963).Google Scholar
  56. Druckrey, H., Schildbach, A., Schmähl, D., Preussmann, R., Ivankovic, S.: Quantitative Analyse der carcinogenen Wirkung von Diäthylnitrosamin. Arzneimittel-Forsch. 13, 844–851 (1963).Google Scholar
  57. Druckrey, H., Schmähl, D.: Die Summationswirkung. Med. Klin. 55, 648–655 (1960).PubMedGoogle Scholar
  58. Druckrey, H., Schmähl, D., Dischler, W.: Dosis-Wirkung-Beziehung bei der Krebserzeugung durch 4-Dimethylaminostilben bei Ratten. Z. Krebsforsch. 65, 272–288 (1963).Google Scholar
  59. Druckrey, H., Schmähl, D., Dischler, W., Schildbauer, A.: Quantitative Analyse der experimentellen Krebserzeugung. Naturwissenschaften 49, 217–228 (1962).Google Scholar
  60. Dumbell, K., Rous, P.: Are carcinogens responsible for experimental neoplastic changes occurring in mouse tumor cells? The effect of methylcholanthrene and urethane on pulmonary adenomas and of methylcholanthrene on mammary carcinomas. J. exp. Med. 102, 517–544 (1955).PubMedGoogle Scholar
  61. Duran-Reynals, M.L.: Combined effects of chemical carcinogenic agents and viruses. Progr. exp. Tumor Res. 3, 148–185 (1963).PubMedGoogle Scholar
  62. Duuren, B.L.van: Tumor-promoting agents in two-stage carcinogenesis. Progr. exp. Tumor Res. (Basel) 11, 31–68 (1969).Google Scholar
  63. Duuren, B.L. van, Melchionne, S.: Inhibition of tumorigenesis. Progr. exp. Tumor Res. (Basel) 12, 55–94 (1969).Google Scholar
  64. Endo, H., Ono, T., Sugimura, T.: Chemistry and biological actions of 4-nitroquinoline 1-oxide. Recent Results Cancer Res. 34, 1–101 (1971).Google Scholar
  65. Engelbreth-Holm, J., Poulsen, O.: Accelerated development of spontaneous leukemia and mammary carcinoma in mice after ingestion of carcinogenic hydrocarbon. Acta path. microbiol. scand. 21, 472–479 (1944).Google Scholar
  66. Epstein, J.H.: Ultraviolet carcinogenesis, In: Photophysiology ed. A.C. Giese, Vol. 5, p. 235–273. New York-London: Academic Press 1970.Google Scholar
  67. Epstein, J.H., Epstein, W.L.: A study of tumor types produced by ultraviolet light in hairless and hairy mice. J. invest. Derm. 41, 463–473 (1963).PubMedGoogle Scholar
  68. Falk, H.L.: Anticarcinogenesis—an alternative. Progr. exp. Tumor Res. (Basel) 14, 105–137 (1971).Google Scholar
  69. Falk, H.L., Kotin, P., Thompson, S.: Inhibition of carcinogenesis. The effect of polycyclic hydrocarbons and related compounds. Arch. environm. Hlth 9, 169–179 (1964).Google Scholar
  70. Fischer, B.: Die experimentelle Erzeugung atypischer Epithelwucherung und die Entstehung bösartiger Geschwülste. Münch. med. Wschr. 53, 2044–2047 (1906).Google Scholar
  71. Friedewald, W. F.: Cell state as affecting susceptibility to a virus. Enhanced effectiveness of the rabbit papilloma virus on hyperplastic epidermis. J. exp. Med. 75, 197–219 (1942).PubMedGoogle Scholar
  72. Friedewald, W.F., Rous, P.: The initiating and promoting elements in tumor production. J. exp. Med. 80, 101–126 (1944a).PubMedGoogle Scholar
  73. Friedewald, W.F., Rous, P.: The determining influence of tar, benzpyrene and methylcholanthrene on the character of the benign tumors induced therewith in rabbit skin. J. exp. Med. 80, 127–144 (1944b).PubMedGoogle Scholar
  74. Friedewald, W. F., Rous, P.: The pathogenesis of deferred cancer. A study of the after-effects of methylcholanthrene upon rabbit skin. J. exp. Med. 91, 475–484 (1950).Google Scholar
  75. Furth, J.: The role of mammosomatotropin in tumorigenesis of the mammary gland. Endogenous factors influencing host-tumor balance ed. R. W. Wissler, T.L. Dao, W. Wood, p. 49–62. Chicago, London: Chicago Univ. Press 1967.Google Scholar
  76. Gardener, W. U.: Hormonal aspects of experimental tumorigenesis. Advanc. Cancer Res. 1, 173–232 (1953).Google Scholar
  77. Gelboin, H.V.: Carcinogens: enzyme induction and gene action. Advanc. Cancer Res. 10, 1–81 (1967).Google Scholar
  78. Graffi, A.: Betrachtungen zu den Theorien der Krebsentstehung. Arch. Geschwulstforsch. 22, 13–41 (1963).PubMedGoogle Scholar
  79. Graffi, A., Scharsach, F., Hever, E.: Zur Frage der Initialwirkung cancerogener Kohlenwasserstoffe auf die Mäusehaut nach intravenöser, intraperitonealer und oraler Applikation. Naturwissenschaften 42, 184 (1955).Google Scholar
  80. Grucksmann, A.: Histogenesis of radiation-induced and of benzpyrene-induced epidermal tumours in the mouse. J. path. Bact. 63, 176–177 (1951).Google Scholar
  81. Grucksmann, A.: Skin tumours induced by radiation. Brit. med. Bull. 14, 178–180 (1958).Google Scholar
  82. Grucksmann, A.: Carcinogenesis. In: Cellular basis and etiology of late somatic effects of ionizing radiation, Ed. J.C. Harris, p. 121–133. New York, London: Academic Press 1963.Google Scholar
  83. Grucksmann, A., Lamerton, I. F., Mayneord, W. V.: Carcinogenic effects of radiation. In: Cancer, ed. R.W. Raven, vol. 1, p. 497–539. London: Butterworth 1957.Google Scholar
  84. Gruenstein, M., Shay, H., Simlin, M.R.: Lack of effect of norethynodrel on methylcholanthrene-induced mammary carcinogenesis in female rats. Cancer Res. 24, 1656–1658 (1964).PubMedGoogle Scholar
  85. Hueper, W.C., Conway, W.D.: Chemical carcinogenesis and cancers. Springfield, Thomas 1964.Google Scholar
  86. Haddow, A.: The chemical and genetic mechanism of carcinogenesis, in: Physiopathol. Cancer ed. Homburger and Fishman, p. 441–551. New York: Hoeber 1953.Google Scholar
  87. Haddow, A., Harris, R.J.C., Kon, G.A.R., Roe, E.M.F.: The growth-inhibiting and carcinogenic properties of 4-aminostilbene and derivatives. Phil. Trans. A. 241, 147–195 (1948).Google Scholar
  88. Hayatsu, H., Hoshino, H., Kawazoe, Y.: Potential carcinogenicity of sodium hypochlorite. Nature (Lond.) 233, 495 (1971).Google Scholar
  89. Hecker, E.: Phorbol esters from croton oil: Chemical nature and biological activities. Naturwissenschaften 54, 282–284 (1967).PubMedGoogle Scholar
  90. Hecker, E.: Biochemische und molekular-biologische Probleme der Tumorgenese. Arzneimittel-Forsch. 18, 978–989 (1968).Google Scholar
  91. Heston, W. E.: Relationship between susceptibility to induced pulmonary tumors and certain known genes in mice. J. nat. Cancer Inst. 2, 127–132 (1941).Google Scholar
  92. Hieger, I.: On the mechanism of carcinogenesis by chemical compounds. Amer. J. Cancer 28, 522–529 (1936).Google Scholar
  93. Hill, W.T., Stanger, D.W., Pizzo, A., Riegel, B., Shubik, P., Wortman, W.B.: Inhibition of 9,10-dimethyl-1,2-benzanthracene skin carcinogenesis in mice by polycyclic hydrocarbons. Cancer Res. 11, 892–897 (1951).PubMedGoogle Scholar
  94. Horton, A. W., Denman, D. T.: Carcinogenesis of the skin. A re-examination of methods for quantitative measurement of potencies of complex materials. Cancer Res. 15, 701–709 (1955).PubMedGoogle Scholar
  95. Hoshino, H., Chihara, G., Fukuoka, F.: Detection of potentially weak carcinogens and procarcinogens. II. Carcinogenicity of tertiary butyl hydroperoxide. Gann 61, 121–124 (1970).PubMedGoogle Scholar
  96. Hoshino, H., Tanooka, H., Fukuoka, F.: Summation of carcinogenic effect of 4-nitroquinoline 1-oxide and ß-rays. Gann 59, 43–49 (1968).PubMedGoogle Scholar
  97. Huggins, C., Grand, L.C., Briliantes, F.P.: Rapid induction of mammary carcinoma in the rat and the influence of hormones on the tumors. J. exp. Med. 109, 25–42 (1956).Google Scholar
  98. Huggins, C., Grand, L, C., Briliantes, F.B.: Mammary cancer induced by a single feeding of polynuclear hydrocarbons, and its suppression. Nature (Lond.) 189, 204–207 (1961).Google Scholar
  99. Huggins, C., Lorraine, G., Fukunishi, R.: Aromatic influences on the yields of mammary cancers following administration of 7,12-dimethylbenz (a) anthracene. Proc. nat. Acad. Sci. (Wash.) 51, 737–742 (1964).Google Scholar
  100. Huggins, C., Yang, N.C.: Induction and extinction of mammary cancer. Science 137, 257–262 (1962).PubMedGoogle Scholar
  101. Irving, C.C., Wiseman, R., JR.: Studies on the carcinogenicity of N-hydroxy-2-acetylaminofluorene and N-2-fluorenylhydroxyl-amine in the rat. Cancer Res. 31, 1645–1648 (1971).PubMedGoogle Scholar
  102. Ivankovic, S.: Transplacental carcinogenesis of N-nitroso compounds. Proc. 2nd Intern. Symp. Princess Takamatsu Cancer Res. Fund, p. 459–471 (1972).Google Scholar
  103. Kennaway, E.L., Hieger, I.: Carcinogenic substances and their fluorescence spectra. Brit. med. J. 1930I, 1044–1066.Google Scholar
  104. Kinosita, R.: Studies on the carcinogenic substances. Trans. Soc. Pathol. Japon. 27, 665–727 (1937)Google Scholar
  105. Klein, M.: Induction of skin tumors in mice with minute doses of 9,10-dimethylbenzanthracene alone or with croton oil. Cancer Res. 16, 123–127 (1956).PubMedGoogle Scholar
  106. Klein, M.: Inhibition of skin tumorgenesis in strain B6AF/J female mice with maleic anhydride. J. nat. Cancer Inst. 34, 175–186 (1965).PubMedGoogle Scholar
  107. Lacassagne, A.: Apparition de cancers de la mammelle chez la souris mâle à des injections de folliculine. C. R. Acad. Sci. (Paris) 195, 630–632 (1932).Google Scholar
  108. Lacassagne, A., Buu-Hoi, N. P., Hurst, L., Biao, N. B.: Inhibition complète, par la p-hydroxyacéto-phénone, de l’activité cancérogène du jaune de beurre sur le foie du rat. C. R. Acad. Sci. (Paris) 258, 5763–5766 (1964).Google Scholar
  109. Lacassagne, A., Buu-Hoi, N.P., Rudali, G.: Inhibition of the carcinogenic action produced by weakly carcinogenic hydrocarbon on a highly active carcinogenic hydrocarbon. Brit. J. exp. Path. 26, 5–12 (1945).Google Scholar
  110. Lavie, P.S., Moore, P.R., Rusch, H.P., Baumann, C.A.: Some additive effects of carcinogenic hydrocarbons. Cancer Res. 2, 189–192 (1942).Google Scholar
  111. Leitter, J., Shear, M.J.: Quantitative experiments on the production of subcutaneous tumours in strain A mice with marginal doses of 3,4-benzpyrene. J. nat. Cancer Inst. 3, 455–477 (1943).Google Scholar
  112. Lusky, M.L., Braun, H.A., Woodward, G.: Influence of 2,3-dimercaptopropanol on the induction of skin tumors in mice by 3,4-benzpyrene. Cancer Res. 7, 667–668 (1947).Google Scholar
  113. Mackenzie, I., Rous, P.: The experimental disclosure of latent neoplastic changes in tarred skin. J. exp. Med. 73, 391–412 (1941).PubMedGoogle Scholar
  114. Magee, P.N., Barnes, J.M.: The production of malignant primary hepatic tumours in the rat by feeding diethylnitrosamine. Brit. J. Cancer 10, 114–122 (1954).Google Scholar
  115. Magee, P.M., Barnes, J.M.: The experimental production of tumours in the rat by dimethylnitros-amine. Acta Un. int. Cancr. 15, 187–190 (1959).Google Scholar
  116. Magee, N.P., Barnes, J.M.: Carcinogenic nitroso compounds. Advanc. Cancer Res. 10, 163–246 (1967).Google Scholar
  117. Meechan, R.J., McCafferty, D.E., Jones, R.S.: 3-Methylcholanthrene as an inhibitor of hepatic cancer induced by 3’-methyl-4-dimethylaminoazobenzene in the diet of the rat: A determination of the time relationships. Cancer Res. 13, 802–806 (1953).PubMedGoogle Scholar
  118. Merenmies, L.: Zum Mechanismus der Hauttumorbildung bei Mäusesucht mit Hilfe einiger nichtionisierbaren oberflächenaktiven Tumorauslösersubstanzen. Acta path. microbiol. scand., Suppl. 130, 1–30 (1959).Google Scholar
  119. Miller, E.C., Miller, J.A., Brown, R.R., Macdonald, J.C.: On the protective action of certain polycyclic aromatic hydrocarbons against carcinogenesis by aminoazo dyes and 2-acethyl-amino-fluorene. Cancer Res. 18, 469–477 (1958).PubMedGoogle Scholar
  120. Miller, J. A., Miller, E.C.: The carcinogenic amino azo dyes. Advanc. Cancer Res. 1, 339–396 (1953).Google Scholar
  121. Mirvish, S.S.: The carcinogenic action and metabolism of urethan and N-hydroxyurethan. Advanc. Cancer Res. 11, 1–42 (1968).Google Scholar
  122. Mori, K.: Preliminary note on adenocarcinoma of the lung in mice induced with 4-nitroquinoline 1-oxide. Gann 52, 265–270 (1961).PubMedGoogle Scholar
  123. Mori, K.: Induction and transplantation of cancer of the lung in rats. Gann 54, 415–425 (1963).PubMedGoogle Scholar
  124. Mori, K.: Acceleration of experimental lung cancers in rats by inhalation of cigarette smoke. Gann 55, 175–181 (1964).PubMedGoogle Scholar
  125. Mori, K.: Induction of pulmonary and uterine cancers and leukemia in mice by injection of 4-nitroquinoline 1-oxide. Gann 56, 513–518 (1965).PubMedGoogle Scholar
  126. Morris, H.P., Wagner, R.P., Ray, F.E., Stewart, H.L., Snell, K.C.: Comparative carcinogenic effects of N, N’-n,7-fluonylbisacetamide by intraperitoneal and oral routes of administration to rats with particular reference to gastric carcinoma. J. nat. Cancer Inst. 29, 977–1011 (1962).Google Scholar
  127. Mühlbock, O., Boot, L.M.: Induction of mammary cancer in mice without the mammary tumor agents by isografts of hypophyses. Cancer Res. 19, 402–412 (1959).PubMedGoogle Scholar
  128. Muta, Y.: Kombinationsversuch der karzinogenen Wirkungen verschiedener Substanzen. Gann 37, 298–300 (1943).Google Scholar
  129. Nagayo, T., Ito, M., Yamada, S.: Histogenesis and autoradiography of adenocarcinoma of the glandular stomach in rats induced by oral administration of N, N’-2,7-fluorenylenebisacetamide combined with irradiation to the stomach region. Gann 63, 143–151 (1972).PubMedGoogle Scholar
  130. Nakahara, W.: Critique of carcinogenic mechanism. Progr. exp. Tumor Res. (Basel) 2, 158–202 (1961).Google Scholar
  131. Nakahara, W.: Newer studies on the carcinogenic action of quinoline N-oxide derivatives. Arzneimit-tel-Forsch. 14, 842–844 (1964).Google Scholar
  132. Nakahara, W.: Summation synkarzinogener Wirkungen. Med. Klin. 61, 661–664 (1966).PubMedGoogle Scholar
  133. Nakahara, W.: Mode of origin and characterization of cancer. Chem. Tumor Probl, ed. W. Nakahara, p. 286–330. Tokyo: Japan Soc. Prom. Sci. 1970.Google Scholar
  134. Nakahara, W.: Syncarcinogenic role of oncogenic virus. Gann Monogr. Cancer Res. 12, 311–312 (1972).Google Scholar
  135. Nakahara, W., Fukuoka, F.: Inhibitation of liver cancer production by blood meal feeding, with special reference to the significance of liver catalase. Gann 35, 428–432 (1944).Google Scholar
  136. Nakahara, W., Fukuoka, F.: Study of carcinogenic mechanism based on experiments with 4- nitroquinoline N-oxide. Gann 50, 1–15 (1959a).Google Scholar
  137. Nakahara, W., Fukuoka, F.: On the mechanism of radiation carcinogenesis. Gann 50, 17–21 (1959b).Google Scholar
  138. Nakahara, W., Fukuoka, F.: Summation cancerogener Wirkungen von chemisch verschiedenartigen Cancerogenen. Naturwissenschaften 47, 44–45 (1960a).Google Scholar
  139. Nakahara, W., Fukuoka, F.: Summation of carcinogenic effects of chemically unrelated carcinogens, 4-nitroquinoline N-oxide and 20-methylcholanthrene. Gann 51, 125–137 (1960b).PubMedGoogle Scholar
  140. Nakahara, W., Fukuoka, F., Sugimura, T.: Carcinogenic action of 4-nitroquinoline N-oxide. Gann 48, 129–137 (1957).Google Scholar
  141. Nakahara, W., Mori, K.: Experimental production of liver cirrhosis by furfural feeding. Gann 35, 208–230 (1941).Google Scholar
  142. Nakahara, W., Mori, K., Fujiwara, T.: Inhibition of experimental production of liver cancer by liver feeding; a study in nutrition. Gann 33, 406–427 (1939).Google Scholar
  143. Nettleship, A., Henshaw, P.S., Meyer, H.L.: Induction of pulmonary tumors in mice with ethyl carbamate (Urethane). J. nat. Cancer Inst. 4, 309–319 (1943).Google Scholar
  144. Niskanen, E. E.: Mechanism of skin tumorigenesis in mouse. Acta path. microbiol. scand., Suppl. 159, 5–52 (1962).Google Scholar
  145. Niskanen, E.E., Merenmies, L.: Morphological effect on mouse skin of orally administered carcinogens. Naturwissenschaften 46, 583 (1959).Google Scholar
  146. Niskanen, E. E., Merenmies, L.: The determining influence of the dose and nature of orally administered carcinogen on mouse skin tumors produced with Tween 40. Naturwissenschaften 47, 46 (1960).Google Scholar
  147. Nowell, P.C., Cole, L.E., Ellis, M.E.: Neoplasms of the grandular stomach in mice irradiated with X-rays or fast neutrons. Cancer Res. 18, 257–260 (1958).PubMedGoogle Scholar
  148. Odashima, S.: Development of liver cancer in the rat by 20-methylcholanthrene painting following initial 4-dimethylaminoazobenzene feeding. Gann 60, 342–345 (1959).Google Scholar
  149. Odashima, S.: Combined effect of carcinogens with different actions. I. Development of liver cancer in the rat by the feeding of 4-dimethylaminostilbene following initial feeding of 4-dimethylaminoazobenzene. Gann 53, 247–257 (1962a).PubMedGoogle Scholar
  150. Odashima, S.: Combined effect of carcinogens with different actions. II. Effect of pretreatment of painting with 20-methylcholanthrene or feeding of 4-dimethylaminostilbene upon carcinogenesis of 4-dimethylaminoazobenzene in the rat. Gann 53, 259–268 (1962b).PubMedGoogle Scholar
  151. Odashima, S.: Combined effect of carcinogens with different actions. III. Development of skin cancers in the rat by feeding 4-dimethylaminostilbene following initial painting of 20-methylchol-anthrene. Gann 53, 269–274 (1962c).PubMedGoogle Scholar
  152. Orr, J.W.: The mechanism of chemical carcinogenesis, with particular reference to the time of development of irreversible changes in the epithelial cells. Brit. med. Bull. 14, 99–101 (1958).PubMedGoogle Scholar
  153. Pitot, H.C., Heidelberger, C.: Metabolic regulatory sircuits and carcinogenesis. Cancer Res. 23, 1694–1700 (1963).PubMedGoogle Scholar
  154. Poel, W. E.: Effects of carcinogenic dosages and duration of exposure on the skin-tumor induction in mice. J. nat. Cancer Inst. 22, 19–43 (1959).PubMedGoogle Scholar
  155. Poel, W. E.: Skin as a test site for the bioassay of carcinogens and carcinogenic precursors. Nat. Cancer Inst. Monogr. 10, 611–632 (1963).Google Scholar
  156. Poel, W. E.: The cause and nature of cancer. Progr. exp. Tumor Res. (Basel) 5, 53–84 (1964).Google Scholar
  157. Prehn, R.T.: Immunosurveilance, regeneration and oncogenesis. Progr. exp. Tumor Res. (Basel) 14, 1–34 (1971).Google Scholar
  158. Richardson, H.L., Cunnigham, L.: The inhibitory action of methylcholanthrene on rats fed the azo dye 3-methyl-4-dimethylamino-azobenzene. Cancer Res. 11, 274 (1951).Google Scholar
  159. Richardson, H. L., Stier, A. R., Bobson-Nachtnebel, E.: Liver tumor inhibition and adrenal histologic response in rats to which 3’-methyl-4-dimethylaminoazobenzene and 20-methylcholanthrene were simultaneously administered. Cancer Res. 12, 356–361 (1952).PubMedGoogle Scholar
  160. Riegel, B., Wartman, W.B., Hill, W.T., Reeb, B.B., Shubik, P., Stanger, D.W.: Delay of methylcholanthrene skin carcinogenesis in mice by 1,2,5,6-dibenzofluorene. Cancer Res. 11, 301–303 (1951).PubMedGoogle Scholar
  161. Roe, J. C.: The development of malignant tumours in mouse skin after “initiating” and “promoting” stimuli. III. The carcinogenic action of croton oil. Brit. J. Cancer 10, 72–78 (1956).PubMedGoogle Scholar
  162. Roe, J.C., Boyland, E., Gorrod, J.W.: The importance of looking for further carcinogens in tobacco smoke, and the possible role nitrosoanabasine. Alkyl. wirk. Verbindungen. Int. Konf. N-Nitroso-Verbindungen und Lactone, p. 85–90, Hamburg 1963.Google Scholar
  163. Roe, F. J. C., Salaman, M. H.: A quantitative study of the power and persistence of the tumor-initiating effect of ethylcarbamate (urethane) of mouse skin. Brit. J. Cancer 8, 666–676 (1954).PubMedGoogle Scholar
  164. Rous, P., Kidd, J.C.: The carcinogenic effect of a papilloma virus on the tarred skin of rabbits. J. exp. Med. 67, 399–427 (1938).PubMedGoogle Scholar
  165. Rous, P., Kidd, J.C.: Conditional neoplasma and subthreshold neoplastic state. A study of the tar tumors of rabbits. J. exp. Med. 73, 365–389 (1941).PubMedGoogle Scholar
  166. Rous, P., Smith, W.E.: The neoplastic potentialities of mouse embryo tissues. J. exp. Med. 81, 597–646 (1945).PubMedGoogle Scholar
  167. Rubin, B. A.: Carcinogen-induced tolerance to homotransplantation. Progr. exp. Tumor Res. (Basel) 5, 217–292 (1964).Google Scholar
  168. Rubin, B.A.: Alteration of the homograft response as a determinant of carcinogenicity. Progr. exp. Tumor Res. (Basel) 14, 138–195 (1971).Google Scholar
  169. Rubin, B.A., Ida, N.: Studies on the mechanism of growth enhancement of transplanted mouse tumors by carcinogens. Proc. Amer. Ass. Cancer Res. 2, 244 (1957).Google Scholar
  170. Saffiotti, U.: Experimental respiratory tract carcinogenesis. Progr. exp. Tumor Res. (Basel), 11, 302–333 (1969).Google Scholar
  171. Saffiotti, U., Shubik, P.: Studies on promoting action in skin carcinogenesis. Nat. Cancer Inst. Monogr. 10, 489–507 (1963).Google Scholar
  172. Salaman, M.H., Roe, F.J.C.: Cocarcinogenesis. Brit. med. Bull. 20, 139–144 (1964).PubMedGoogle Scholar
  173. Sasaki, T., Yoshida, T.: Experimentelle Erzeugung des Lebercarcinoms durch Fütterung mit o-Aminoazotoluol. Arch. Path. Anat. Physiol. 295, 175–200 (1935).Google Scholar
  174. Schmähl, D.: Synkarzinogenese. Dtsch. med. Wschr. 91, 1799–1800 (1966a).PubMedGoogle Scholar
  175. Schmähl, D.: Die experimentelle Synkarzinogenese. Aktuelle Probleme a.d. Gebiete d. Cancerologie, p. 81–83. Berlin-Heidelberg-New York: Springer 1966b.Google Scholar
  176. Schmähl, D.: Entstehung, Wachstum und Chemotherapie maligner Tumoren. Arzneimittel-Forsch. 21. Beiheft 1969.Google Scholar
  177. Schmähl, D.: Syncarcinogenesis: experimental investigations. In: Chemical tumor problems, ed. W. Nakahara, p. 1–18. Tokyo: Jap. Soc. Prom. Sci. 1970a.Google Scholar
  178. Schmähl, D.: Experimentelle Untersuchungen zur Synkarzinogenese. 6. Mitteilung. Addition minimaler Dosen von vier verschiedenen hepatotropen Carcinogenen bei der Leberkrebserzeugung bei Ratten. Z. Krebsforsch. 74, 457–466 (1970b).PubMedGoogle Scholar
  179. Schmähl, D., Mecke, R.: Quantitative Untersuchung der carcinogenen Wirksamkeit von 4-Aminostilben. Z. Krebsforsch. 61, 230–239 (1956).PubMedGoogle Scholar
  180. Schmähl, D., Preussmann, R.: Carcinogene Wirkung von Nitrosodimethylamin bei Ratten. Naturwissenschaften 46, 175 (1959).Google Scholar
  181. Schmähl, D., Thomas, C.: Experimentelle Untersuchungen zur Synkarzinogenese. 4. Mitteilung. Versuche zur Krebserzeugung bei Ratten bei gleichzeitiger oraler Gabe von Diätylnitrosamin und 4-Dimethylaminostilben. Z. Krebsforsch. 67, 135–140 (1965).PubMedGoogle Scholar
  182. Schmähl, D., Thomas, C., Brune, H.: Experimentelle Untersuchungen zur „Synkarzinogenese“. 2. Mitteilung. Versuche zur Krebserzeugung bei Mäusen bei gleichzeitiger Applikation von Urethan und 9,10-Dimethyl-1,2-benzanthracen. Z. Krebsforsch. 66, 297–302 (1964).Google Scholar
  183. Schmähl, D., Thomas, C., König, K.: Versuche zur Krebserzeugung mit Diethylnitrosamin bei Mäusen. Naturwissenschaften 50, 406 (1963).Google Scholar
  184. Schmähl, D., Thomas, C., König, K.: Experimentelle Untersuchungen zur „Synkarzinogenese“. 1. Mitteilung. Versuche zur Krebserzeugung an Ratten bei gleichzeitiger Applikation von Diäthylnitrosamin und 4-Dimethylaminobenzen. Z. Krebsforsch. 65, 342–350 (1963).PubMedGoogle Scholar
  185. Schmähl, D., Thomas, C., Sattler, W., Scheld, G.F.: Experimentelle Untersuchung zur “Synkar-cinogenese”. 3. Mitteilung. Versuche zur Krebserzeugung an Ratten bei gleichzeitiger Gabe von Diäthylnitrosamin und Tetrachlorkohlenstoff bzw. Äthylalkohol; zugleich ein experimenteller Beitrag zur Frage der „Alkoholcirrhose“. Z. Krebsforsch. 66, 526–532 (1964/65).Google Scholar
  186. Schmähl, D., Stutz, E., Thomas, C: Experimentelle Untersuchungen zur Synkarzinogenese. 5. Mitteilung. Versuche zur Krebserzeugung an A Ratten bei gleichzeitiger Applikation von Röntgenstrahlen und Diäthylnitrosamin oder 4-Dimethylamino-diphenyl. Z. Krebsforsch. 68,68–72 (1966).PubMedGoogle Scholar
  187. Scott, B., Christian, H.J., Currie, A.R.: The Huggins rat mammary tumors: cellular changes associated with regression. Endogenous factors influencing host-tumor balance, ed. R. W. Wissler, T.L. Dao, S. Wood, p. 99–113. Chicago & London: Chicago Univ. Press 1967.Google Scholar
  188. Searle, C. E., Woodhouse, D. L.: 4-Nitroquinoline 1-oxide: an inhibitor of benzpyrene carcinogenesis of mouse skin. Cancer Res. 24, 245–249 (1964).PubMedGoogle Scholar
  189. Setala, H.: Tumor promoting and co-carcinogenic effects of some non-ionic lipophilic-hydrophilic (surface active) agents. An experimental study on skin tumors in mice. Acta path, microbiol. scand., Suppl. 115, 7–91 (1956).Google Scholar
  190. Setala, K.: Progress in carcinogenesis, tumor-enhancing factors. A bio-assay of skin tumor formation. Progr. exp. Tumor Res. (Basel) 1, 223–228 (1960).Google Scholar
  191. Shay, H., Aegaerter, E.A., Gruenstein, M., Komarov, S.A.: Development of adenocarcinoma of the breast in the Wister rat following the gastric instillation of methylcholanthrene. J. nat. Cancer Inst. 10, 255–266 (1949).PubMedGoogle Scholar
  192. Shear, M.J., Lorenz, E.: Studies in carcinogenesis. VI. Hydrocarbon-cholesterol pellets in albino mice. Amer. J. Cancer 36, 201–210 (1939).Google Scholar
  193. Shubik, P.: The growth potentialities of induced skin tumors in mice. The effects of different methods of chemical carcinogenesis. Cancer Res. 10, 713–717 (1950).PubMedGoogle Scholar
  194. Smith, W.E., Rous, P.: The neoplastic potentialities of mouse embryo tissues. II. Contributary experiments: results with the skin of C3H and Webster-Swiss embryos: general considerations. J. exp. Med. 81, 621–646 (1945).PubMedGoogle Scholar
  195. Southam, C.M., Tanaka, S., Arata, T., Sinkovic, D., Miura, M., Petropulos, S.F.: Enhancement of responses to chemical carcinogens by nononcogenic viruses and antimetabolites. Progr. exp. Tumor Res. (Basel) 11, 194–212 (1969).Google Scholar
  196. Spitz, S., Maguigan, W.H., Dobriner, K.: The carcinogenic action of benzidine. Cancer (Philad.) 3, 789–804 (1950).Google Scholar
  197. Steiner, P. E.: Carcinogenicity of multiple chemicals simultaneously administered. Cancer Res. 15, 632–635 (1955).PubMedGoogle Scholar
  198. Steiner, P.E., Falk, H.L.: Summation and inhibition effects of weak and strong carcinogenic hydrocarbons: 1,2-benzanthracene, chrysene, 1,2,5,6-dibenzanthracene, and 20-methylcholanthrene. Cancer Res. 11, 58–63 (1951).Google Scholar
  199. Stjernsward, J.: Immunodepressive effect of 3-methylcholanthrene. Antibody formation at the cellular level and reaction against weak antigenic homografts. J. nat. Cancer Inst. 35, 885–892 (1965).PubMedGoogle Scholar
  200. Stutz, E., Bluthgen, U.: Rontgenkarzinom des Rattenschwanzes, Strahlentherapie 105, 278–295 (1958).PubMedGoogle Scholar
  201. Sugimura, T.: Decarcinogenesis, a new concept arising from our understanding of cancer phenotype. In: Chemical tumor problems, ed. W. Nakahara, p. 269–284. Tokyo: Jap. Soc. Prom. Sci. 1970.Google Scholar
  202. Takayama, S.: Skin carcinogenesis with a single painting of 4-nitroquinoline N-oxide. Gann 51, 139–145 (1960).PubMedGoogle Scholar
  203. Takayama, S.: Effect of 4-nitroquinoline 1-oxide painting on azo dye hepatocarcinogenesis in rats, with note on induction of skin fibrosarcoma. Gann 52, 165–171 (1961).PubMedGoogle Scholar
  204. Takayama, S., Imaizumi, T.: Sequential effects of chemically different carcinogens, dimethylnitros-amine and 4-dimethylaminoazobenzene, on hepatocarcinogenesis in rats. Inst. J. Cancer 4, 373–383 (1969).Google Scholar
  205. Takayama, S., Oota, K.: Malignant tumors induced in mice fed with N-nitrosodimethylamine. Gann 54, 465–472 (1963).PubMedGoogle Scholar
  206. Takayama, S., Oota, K.: Induction of malignant tumors in various strains of mice by oral administration of N-nitromethylamine and N-nitrosodiethylamine. Gann 56, 189–199 (1965).PubMedGoogle Scholar
  207. Tannenbaum, A., Silverstone, H.: Urethane (ethylcarbamate) as a multiple carcinogen. Cancer Res. 18, 1225–1231 (1958).PubMedGoogle Scholar
  208. Tomatis, L.: Prenatal exposure to chemical carcinogens. Proc. 2nd Intern. Symp. Princess Takamatsu Cancer Res. Fund, p. 441–457 (1972).Google Scholar
  209. Tsutsui, H.: Uber das kiinstlich erzeugte Cancroid bei der Maus. Gann 12, 17–21 (1918/1919).Google Scholar
  210. Twort, J.M., Twort, C.C.: Comparative activity of some carcinogenic hydrocarbons. Amer. J. Cancer 35, 80–85 (1939).Google Scholar
  211. Wattenberg, L.W.: The role of portal of entry in inhibition of tumorigenesis. Progr. exp. Tumor Res. (Basel) 14, 89–104 (1971).Google Scholar
  212. Wattenberg, L.W., Leong, J.L.: Inhibition of the carcinogenic action of 7,12-dimethylbenz(a)an- thracene by Beta-naphthoflavone. Proc. Soc. exp. Biol. (N. Y.) 128, 940–943 (1968).Google Scholar
  213. Wattenberg, L. W., Leong, J. L.: Inhibition of the carcinogenic action of benzo(a)pyrene by flavones. Cancer Res. 30, 1922–1925 (1970).PubMedGoogle Scholar
  214. Weisburger, E. K., Weisburger, J. H.: Chemistry, carcinogenicity and metabolism of 2-fluorenamine and related compounds. Advanc. Cancer Res. 5, 331–431 (1958).Google Scholar
  215. Weisburger, J.H., Grantham, P.H., Vanhorn, E., Steigbigel, N.H., Rall, D.P., Weisburger, E.K.: Activation and detoxication of N-2-fluorenylacetamide in man. Cancer Res. 24, 475–479 (1964).PubMedGoogle Scholar
  216. Weisburger, J. H., Weisburger, E. K., Griswald, D., Casey, A. E.: Reduction of carcinogen-induced breast cancer in rats by an antifertility drug. Life Sci. 7, 259–268 (1968).PubMedGoogle Scholar
  217. Wheatley, D.N.: Enhancement and inhibition of the induction by 7,12-dimethylbenz(a)anthracene of mammary tumors in female Sprage-Dawley rats. Brit. J. Cancer 22, 787–792 (1968).PubMedGoogle Scholar
  218. Wilson, R.H., Deeds, F., Cox, A.J., Jr.: The toxicity and carcinogenic activity of 2-acetamino-fluorene. Cancer Res. 1, 595–608 (1941).Google Scholar
  219. Wynder, W.L., Taguchi, K., Baden, V., Hoffmann, D.: Effect of passive inhalation of cigarette smoke on the respiratory tract of mice and hamsters. Proc. Amer. Cancer Res. 7, 77 (1966).Google Scholar
  220. Yamagiwa, K., Ichikawa, K.: Experimentelle Studie über die Pathogenese der Epithelialgeschwülste. Mitteil. Med. Fakult. Kaiserl. Univ. Tokyo 15, 295–344 (1915).Google Scholar
  221. Yanai, R., Nagasawa, H.: Inhibition by ergocornine and 2-Br-α-ergocryptin of spontaneous mammary tumor appearance. Experientia (Basel) 27, 934 (1971).Google Scholar
  222. Yoshida, T.: Über die experimentelle Erzeugung von Hepatom durch die Fütterung mit O-Aminoazotoluol. Proc. Imp. Acad. Japan 8, 464–467 (1932).Google Scholar

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© Springer-Verlag Berlin Heidelberg 1975

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  • W. Nakahara

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