Pharmacodynamic Mechanism in Carcinogenesis

  • W. Nakahara
Part of the Handbuch der allgemeinen Pathologie book series (PATHOLOGIE, volume 6 / 6)


Investigation of the mechanism of carcinogenesis has now come to include interaction between carcinogenic molecules and competent biologic molecules of cellular components, involving quantum biological, organic chemical, and enzymatic reactions. Changes in cell behavior have been observed after the successful transformation of normal cells to malignant cells in tissue culture. The entire problem, moreover, is at a major turning point, on account of the increasing impact of recent studies on so-called oncogenic viruses. None of these attempts to determine the carcinogenic mechanism has as yet yielded any final conclusion that is applicable to all types of carcinogens and is unconditionally acceptable. However, we can use experimental results on the pharmacodynamic action of carcinogens to formulate a system of thought on the nature of the carcinogenic mechanism.


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© Springer-Verlag Berlin Heidelberg 1975

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  • W. Nakahara

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