Summary
The immunological findings in Hodgkin’s disease and chronic lymphocytic leukemia are reviewed and described on the basis of the concept of thymus-derived (T) and bone-marrow-derived (B) lymphocytes. Environmental and genetic factors appear to be involved in the pathogenesis of Burkitt lymphoma and Hodgkin’s disease respectively. The pathogenesis of malignant lymphoma in general is discussed on the basis of a recently developed hypothesis.
There is considerable experimental and clinical evidence for the existence of two populations of lymphocytes, a thymus-derived or thymus-dependent (T) population mediating cellular immunity, and a bone marrow-derived (B) population mediating humoral immunity [1]. This concept has proved helpful in the characterization of primary and secondary immune deficiences. Impairment of cell-mediated immunity results in a decreased ability of the organism to express delayed skin reactivity, homograft rejection and defense against viral infections. Defects in humoral immunity are characterized by impairment of antibody production and low levels of one or several classes of immunoglobulins. The purpose of this study is 1) to describe immunological features of malignant lymphomas on the basis of the concept of T and B cells and 2) to collate immunological phenomena with hypotheses for pathogenetic mechanisms of malignant lymphoma.
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References
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Flad, HD. (1974). Immunology and Immune Reactions in Malignant Lymphoma. In: Musshoff, K. (eds) Diagnosis and Therapy of Malignant Lymphoma. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 46. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80829-6_8
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DOI: https://doi.org/10.1007/978-3-642-80829-6_8
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