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Chromosome Changes in Human Malignant Tumors: An Evaluation

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Special Topics in Carcinogenesis

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 44))

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Abstract

It appears extremely unlikely that visual microscopy, including the application of new techniques such as that of fluorescent staining [7] and the determination of the “banding” patterns of human chromosomes [4, 40], will yield in the near future any characteristic or specific cytogenetic finding similar to that of the Ph1-chromosome in chronic myelocytic leukemia (CML) [38]. The description of the latter by Nowell and Hungerford [38] remains a singular milestone in the field of medical oncology and cytogenetics. Hence, this paper will deal with an assessment and evaluation of published chromosomal findings in human leukemia and cancer as these bear upon:

  1. 1.

    Specificity of karyotypic alterations in human neoplasia,

  2. 2.

    The role of chromosomal changes (including “markers”) in the causation of human cancer and leukemia, and

  3. 3.

    Possible future application of cytogenetic data in the diagnosis and treatment of these diseases.

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Authors
  1. A. A. Sandberg
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Editors and Affiliations

  1. Pathologisches Institut der Universität, D 4400, Münster, Westring 17, Germany

    E. Grundmann

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© 1973 Springer-Verlag Berlin · Heidelberg

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Sandberg, A.A. (1973). Chromosome Changes in Human Malignant Tumors: An Evaluation. In: Grundmann, E. (eds) Special Topics in Carcinogenesis. Recent Results in Cancer Research, vol 44. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80786-2_13

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  • DOI: https://doi.org/10.1007/978-3-642-80786-2_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80788-6

  • Online ISBN: 978-3-642-80786-2

  • eBook Packages: Springer Book Archive

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