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Biosynthesis

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Prostaglandins

Part of the book series: Monographs on Endocrinology ((ENDOCRINOLOGY,volume 7))

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Abstract

The enzymatic conversion of all-cis-5,8,11,14-eicosatetraenoic acid (arachidonic acid) to PGE2 was discovered independently by D. A. van Dorp in the Netherlands and S. Bergström in Sweden (van Dorp, Beerthuis, Nugteren and Vonkeman, 1964 a; Bergström, Danielsson and Samuelsson, 1964). PGF2α is also formed from arachidonic acid (Änggård and Samuelsson, 1965) whilst PGE1 and PGF1α are similarly formed from 8,11,14-eicosatrienoic acid (dihomo-γ-linolenic acid), the immediate precursor of arachidonic acid (van Dorp, Beerthuis, Nugteren and Vonkeman, 1964 b; Bergström et al., 1964; Kupiecki, 1965) (Fig. 1). The conversion of all-cis-5,8,11,14,17-eicosapentaenoic acid to PGE3 has also been demonstrated (Bergström et al., 1964).

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Authors and Affiliations

  1. Department of Pharmacology, University of Edinburgh, 1 George Square, Edinburgh, EH8 9JZ, Great Britain

    Professor Eric William Horton D. Sc., F.R.C.P.E.

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  1. Professor Eric William Horton D. Sc., F.R.C.P.E.
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© 1972 Springer-Verlag Berlin · Heidelberg

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Horton, E.W. (1972). Biosynthesis. In: Prostaglandins. Monographs on Endocrinology, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80642-1_4

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  • DOI: https://doi.org/10.1007/978-3-642-80642-1_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80644-5

  • Online ISBN: 978-3-642-80642-1

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