Abstract
In the unanaesthetised dog with either an innervated (Pavlov) or a denervated (Heidenhain) gastric pouch or with a gastric fistula, PGE1 infused intravenously reduces the gastric secretory response to either food, histamine, pentagastrin or deoxyglucose (Fig. 1). At an infusion rate of 1 µg/kg/min, PGE1 totally inhibited secretion induced by either food (23 g of canned meat), histamine (1 mg/hr infused intravenously), pentagastrin (75 µg/kg/min infused intravenously). or 2-deoxyglucose (200 mg/kg injected intravenously). At 0.45 µg PGE1/kg/min there was 60% inhibition. For any dose, maximum inhibition was reached 30 to 45 minutes after the start and was maintained throughout the infusion (Robert, Nezamis and Phillips, 1967, 1968).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ambache, N., Freeman, M. A.: Atropine-resistant longitudinal muscle spasms due to excitation of non-cholinergic neurones in Auerbach’s plexus. J. Physiol. (Lond.) 199, 705–727 (1968).
Bass, P., Bennett, D. R.: Local chemical regulation of motor action of the bowel — substance P and lipid-soluble acids. In: Handbook of Physiology Sec. 6, Alimentary Canal. Ed.: C. F. Code. Washington: American Physiological Society 1968, pp. 2193–2212.
Bennett, A., Eley, K. G., Scholes, G. B.: Effects of prostaglandins E1 and E2 on human, guinea-pig and rat isolated small intestines. Brit. J. Pharmac. 34, 630–638 (1968 a).
Bennett, A., Eley, K. G., Scholes, G. B.: Effect of prostaglandins E1 and E2 on intestinal motility in the guinea-pig and rat. Brit. J. Pharmac. 34, 639–647 (1968 b).
Bergström, S., Eliasson, R., von Euler, U. S., Sjövall, J.: Some biological effects of two crystalline prostaglandin factors. Acta physiol. scand. 45, 133–144 (1959).
Classen, M., Koch, H., Deyhle, P., Weidenhiller, S., Demling, L.: Wirkung von Prostaglandin E1 auf die basale Magensekretion des Menschen. Klin. Wschr. 48, 876–878 (1970).
Fleshler, B., Bennett, A.: Responses of human, guinea pig, and rat colonic circular muscle to prostaglandins. J. Lab. clin. Med. 74, 872–873 (1969).
Ghosh, M. N., Schild, H. O.: Continuous recording of acid gastric secretion in the rat. Brit. J. Pharmac. 13, 54–61 (1958).
Greenough, W. B., Pierce, N. F., Al Awqati, Q., Carpenter, C. C. J.: Stimulation of gut electrolyte secretion by prostaglandins, theophylline and cholera exotoxin. J. clin. Invest. 48, 32 a–33 a (1969).
Horton, E. W.: Biological activities of pure prostaglandins. Experientia 21, 113–118 (1965).
Horton, E. W., Main, I. H. M.: A comparison of the biological activities of four prostaglandins. Br. J. Pharmac. 21, 182–189 (1963).
Horton, E. W., Main, I. H. M.: A comparison of the actions of prostaglandins F2α and E1 on smooth muscle. Brit. J. Pharmac. 24, 470–476 (1965).
Horton, E. W., Main, I. H. M., Thompson, C. J., Wright, P. M.: Effect of orally administered prostaglandin E1 on gastric secretion and gastrointestinal motility in man. Gut 9, 655–658 (1968).
Jacobson, E. D.: Comparison of prostaglandin E1 and norepinephrine on the gastric mucosal circulation. Proc. Soc. exp. Biol. Med. 133, 516–519 (1970).
Jones, R. L.: Pharmacology of prostaglandins A and B. Ph.D. Thesis, University of London.
Kottegoda, S. R.: An analysis of possible nervous mechanisms involved in the peristaltic reflex. J. Physiol. (Lond.) 200, 687–712 (1969).
Main, I. H. M.: Effects of prostaglandin E2 (PGE2) on the output of histamine and acid in rat gastric secretion induced by pentagastrin or histamine. Brit. J. Pharmac. 36, 214–215P (1969).
Misiewicz, J. J., Waller, S. L., Kiley, N., Horton, E. W.: Effect of oral prostaglandin E1 on intestinal transit in man. Lancet 1, 648–651 (1969).
Miyazaki, E., Ishizawa, M., Sunano, S., Syuto, B., Sakagami, T.: Stimulating action of prostaglandin on the rabbit duodenal muscle. Nobel Symposium 2, Prostaglandins. Eds.: S. Bergström and B. Samuelsson. Stockholm: Almqvist and Wiksell 1967, pp. 277–281.
Robert, A.: Antisecretory property of prostaglandins. Prostaglandin Symposium of the Worcester Foundation for Exp. Biol. Eds.: P. W. Ramwell and J. E. Shaw. New York: Interscience 1968, pp. 47–54.
Robert, A., Nezamis, J. E., Phillips, J. P.: Inhibition of gastric secretion by prostaglandins. Amer. J. dig. Dis. 12, 1073–1076 (1967).
Robert, A., Nezamis, J. E., Phillips, J. P.: Effect of prostaglandin E1 on gastric secretion and ulcer formation in the rat. Gastroenterology 55, 481–487 (1968).
Robert, A., Phillips, J. P., Nezamis, J. E.: Inhibition by prostaglandin E1 of gastric secretion in the dog. Gastroenterology 54, 1263 (1968).
Rudick, J., Gonda, M., Janowitz, H. D.: Prostaglandin E1: An inhibitor of electrolyte and stimulant of enzyme secretion in the pancreas. Fedn. Proc. Amer. Soc. exp. Biol. 29, 445 Abs. (1970).
Shaw, J. E., Ramwell, P. W.: Inhibition of gastric secretion in rats by prostaglandin E1. Prostaglandin Symposium of the Worcester Foundation for Exp. Biol. Eds.: P. W. Ramwell and J. E. Shaw. New York: Interscience 1968, pp. 55–66.
Way, L., Durbin, R. P.: Inhibition of gastric acid secretion in vitro by prostaglandin E1. Nature 221, 874–875 (1969).
Wilson, D. E., Levine, R. A.: Decreased canine gastric mucosal blood flow induced by prostaglandin E1: A mechanism for its inhibitory effect on gastric secretion. Gastroenterology 56, 1268 (1969).
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1972 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
Horton, E.W. (1972). Gastro-intestinal Tract. In: Prostaglandins. Monographs on Endocrinology, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80642-1_13
Download citation
DOI: https://doi.org/10.1007/978-3-642-80642-1_13
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-80644-5
Online ISBN: 978-3-642-80642-1
eBook Packages: Springer Book Archive