Experimentelle Befunde zur Funktion der C-Zellen bei gestörtem Calciumstoffwechsel
Experimental Studies on the Function of C-Cells in Impaired Calcium Metabolism
The mitotic activity of thyroid C-cells in the rat was studied by 3H-thymidine autoradiography. The influence of low calcium diet, of low calcium and low phosphorus diet, of PTH and glycerophosphate was investigated. The number of labelled C-cells corresponded neither to the level of serum calcium nor to that of serum phosphorus. Mitotic activity was stimulated by low calcium diet and suppressed by exogenous PTH and glycerophosphate. From the experiments we hypothesize that the physiological role of calcitonin might be inhibition of bone resorption under conditions of restricted calcium intake.
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- Lietz, H., Donath, K.: Cytochemical evidence for the presence of hormonal peptides in thyroid C-cells. In: Calcitonin. Proceedings of the Symposion on Thyrocalcitonin and the C cells. London 1969. London: William Heinemann Medical Books ltd. (in press).Google Scholar