Summary
After treatment with the anti-androgen cyproterone-acetate (30 mg d.) oligoor cryptospermia occured in 5 normal men after 7 1/2–15 1/2 weeks. Fructose in sperm plasma and total gonadotrophins decreased. The number of spermatozoa was within normal range 4–5 months after discontinuing therapy. The inhibition of spermatogenesis is explained by the anti-androgenic effect of CA and the depression of the gonadotrophins. In one case norethisterone-enanthate reduced the number of spermatozoa, too. Gestonorone-capronate had no effect on the gonadotrophins and spermatogenesis in one patient.
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Literatur
Albert, A., Kelly, S., Silver, L., Kobi, S.: J. clin. Endocr. 18, 600 (1958).
Loraine, J. A., Brown, J. B.: J. clin. Endocr. 16, 1l80 (1956).
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© 1970 Springer-Verlag Berlin Heidelberg New York
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Petry, R., Mauss, J., Senge, T., Rausch-stroomann, JG. (1970). Über den Einflu#x00DF; von Cyproteronacetat, Norethisteron#x00F6;nanthat und Gestonoroncapronat auf die Hypophysen-Gonadenachse beim Mann. In: Kracht, J. (eds) Endokrinologie der Entwicklung und Reifung. Symposion der Deutschen Gesellschaft für Endokrinologie in Ulm vom 26.—28. Februar 1970, vol 16. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80591-2_118
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DOI: https://doi.org/10.1007/978-3-642-80591-2_118
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